INT49404

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1995
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 9.16
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgal)
Anatomy Link Frequency
T-lymphocytes 2
leukocytes 1
endothelial cells 1
lymphocytes 1
endothelium 1
Itgal (Mus musculus)
Pain Link Frequency Relevance Heat
psoriasis 220 99.96 Very High Very High Very High
rheumatoid arthritis 16 99.44 Very High Very High Very High
spinal inflammation 1 93.44 High High
cytokine 37 92.64 High High
Osteoarthritis 1 92.48 High High
Inflammation 110 91.96 High High
chemokine 12 89.20 High High
Angina 4 78.12 Quite High
Inflammatory response 1 76.60 Quite High
Bioavailability 5 71.36 Quite High
Disease Link Frequency Relevance Heat
Adhesions 77 100.00 Very High Very High Very High
Psoriasis 250 99.96 Very High Very High Very High
Nicotine Addiction 66 99.72 Very High Very High Very High
Rheumatoid Arthritis 16 99.44 Very High Very High Very High
Mycobacterial Infection 147 97.96 Very High Very High Very High
Infection 128 96.20 Very High Very High Very High
Multiple Sclerosis 102 95.64 Very High Very High Very High
Myocardial Infarction 7 95.56 Very High Very High Very High
Crystal Associated Disease 1 94.64 High High
Vasculitis 1 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD11a (LFA-1) and its ligand play an important role in the interaction between antigen presenting cells and T-lymphocytes.
CD11a Binding (ligand) of in T-lymphocytes
1) Confidence 0.36 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.48 Pain Relevance 0.28
Two of the most important adhesion molecules, expressed exclusively by leukocytes, are CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1 or complement receptor 3), which belong to the ?
CD11a Binding (Two) of in leukocytes associated with adhesions
2) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.87 Pain Relevance 0.05
All variants were tested for CD11a binding in the Jurkat domains of the variant with optimal cell assay.
CD11a Binding (binding) of
3) Confidence 0.32 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.07 Pain Relevance 0
Efalizumab shows dose-dependent nonlinear pharmacokinetics which can be explained by its saturable specific binding to cell surface receptors CD11a.
CD11a Binding (binding) of
4) Confidence 0.32 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.09 Pain Relevance 0
LFA-1, Mac-1, and p159,95, members of the ?
LFA-1 Binding (p159,95) of
5) Confidence 0.25 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.58 Pain Relevance 0.30
The metabolism of efalizumab is through internalization followed by intracellular degradation as a consequence of either binding to cell surface CD11a or through endocytosis.
CD11a Binding (binding) of
6) Confidence 0.25 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.06 Pain Relevance 0.07
Complete saturation and maintenance of CD11a binding site down-regulation on lymphocytes required weekly intravenous doses of 0.6 mg/kg, which corresponds to an efalizumab plasma concentration of 5 ?
CD11a Binding (binding) of in lymphocytes
7) Confidence 0.25 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.22 Pain Relevance 0.07
LFA-1-mediated adhesiveness of SF T lymphocytes was not observed in any of the 10 non-RA patients studied, although cross-linking of the TCR on lymphocytes from these patients rapidly converted LFA-1 to an adhesive state.
LFA-1 Binding (cross-linking) of in T lymphocytes associated with rheumatoid arthritis
8) Confidence 0.22 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7561125 Disease Relevance 1.33 Pain Relevance 0.58
Integrins CD11a and CD18 have been shown to be critical for recruitment of T cells to the lung and to confer host resistance following infection with aerosolized M.tuberculosis [31].
CD11a Binding (Integrins) of in lung associated with mycobacterial infection and infection
9) Confidence 0.18 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.95 Pain Relevance 0
Next we asked whether the potential endothelial ligands for Mac-1, LFA-1 and ?
LFA-1 Spec (whether) Binding (ligands) of
10) Confidence 0.10 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.83 Pain Relevance 0.04
In order to evaluate, whether ICAM-1 and VCAM-1 are available on the luminal surface of the CVOs capillary endothelial cells for the recruitment of circulating Mac-1+, LFA-1+ and ?
LFA-1 Binding (endothelial cells) of in endothelial cells
11) Confidence 0.10 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.81 Pain Relevance 0.06
In conclusion, since CD11a and CD18 are expressed on the cell surface as a heterodimer and ICAM-1 is a ligand for CD11a/CD18, their increased expression may contribute to their adhesion to endothelium in ischemic regions and may lead to the formation of microaggregates.
CD11a Binding (ligand) of in endothelium associated with adhesions
12) Confidence 0.03 Published 2004 Journal J. Atheroscler. Thromb. Section Abstract Doc Link 15067196 Disease Relevance 0.86 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox