INT49405

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 40
Total Number 41
Disease Relevance 27.30
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgal)
Anatomy Link Frequency
T cells 7
leukocytes 5
macrophages 3
monocytes 3
lymphocyte 3
Itgal (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 58 99.52 Very High Very High Very High
Central nervous system 81 98.96 Very High Very High Very High
Angina 11 97.20 Very High Very High Very High
cytokine 166 96.42 Very High Very High Very High
Spinal cord 17 95.68 Very High Very High Very High
Inflammation 287 95.40 Very High Very High Very High
psoriasis 345 92.56 High High
chemokine 72 92.48 High High
spinal inflammation 2 90.52 High High
dexamethasone 154 90.08 High High
Disease Link Frequency Relevance Heat
Adhesions 180 100.00 Very High Very High Very High
Apoptosis 303 99.82 Very High Very High Very High
Myocardial Infarction 33 99.78 Very High Very High Very High
Rheumatoid Arthritis 61 99.52 Very High Very High Very High
Central Nervous System Disease 42 98.96 Very High Very High Very High
Systemic Lupus Erythematosus 75 98.04 Very High Very High Very High
Nicotine Addiction 67 98.04 Very High Very High Very High
Cytomegalovirus Infection 84 98.00 Very High Very High Very High
Thrombosis Related Under Development 22 97.84 Very High Very High Very High
Disease 149 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Skold and colleagues found a higher expression of CD11a, CD54 and CD71 in non-smoker's AM compared with smokers [23].
Gene_expression (expression) of CD11a associated with nicotine addiction
1) Confidence 0.75 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.30 Pain Relevance 0.28
Two of the most important adhesion molecules, expressed exclusively by leukocytes, are CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1 or complement receptor 3), which belong to the ?
Gene_expression (/) of CD11a in leukocytes associated with adhesions
2) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.84 Pain Relevance 0.04
On the fourth day of infestation, the results of flow cytometry indicated that 2% of the host's splenocytes were expressing high levels of CD49 (alpha4 integrin of VLA-4) and low levels of CD11a (alphaL subunit of the integrin LFA-1).
Gene_expression (levels) of CD11a
3) Confidence 0.57 Published 2005 Journal Ann Trop Med Parasitol Section Abstract Doc Link 16004711 Disease Relevance 0.48 Pain Relevance 0.08
On the fourth day of infestation, the results of flow cytometry indicated that 2% of the host's splenocytes were expressing high levels of CD49 (alpha4 integrin of VLA-4) and low levels of CD11a (alphaL subunit of the integrin LFA-1).
Gene_expression (expressing) of CD11a
4) Confidence 0.57 Published 2005 Journal Ann Trop Med Parasitol Section Abstract Doc Link 16004711 Disease Relevance 0.50 Pain Relevance 0.08
T-cells mainly express LFA-1 (CD11a/CD18), which is essential for every step in the process of immune surveillance and mounting an immune response (Dustin et al 2004), namely firm adherence to the wall of blood vessels under blood flow, scanning by T cells of other cells within tissues, and formation of the immunological synapse between T-cells and antigen-presenting cells.
Gene_expression (express) of LFA-1 in blood
5) Confidence 0.52 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.52 Pain Relevance 0.24
Within 24 hours, treatment with efalizumab reduced the level of CD11a expression on T-cells to 25% of pretreatment levels.
Gene_expression (expression) of CD11a in T-cells
6) Confidence 0.52 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.07 Pain Relevance 0
In the above mentioned study (iv, single dose), CD11a expression returned to baseline within 7–10 days following clearance of efalizumab, without showing any signs of lymphocyte depletion.
Gene_expression (expression) of CD11a in lymphocyte
7) Confidence 0.52 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.06 Pain Relevance 0
These data demonstrate that by reducing CD11a on the surface of circulating and cutaneous T-cells, efalizumab is able to reverse both the histological signs of inflammation and the pathological hyperplasia characteristic of plaque psoriasis.
Gene_expression (reducing) of CD11a in T-cells associated with psoriasis, inflammation and hyperplasia
8) Confidence 0.45 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.53 Pain Relevance 0.18
Previous studies on murine MHM24 have shown that, similar to other anti-CD11a antibodies, it is able to inhibit T-cell function.
Gene_expression (antibodies) of CD11a in T-cell
9) Confidence 0.45 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0 Pain Relevance 0
On the fourth day of infestation, the results of flow cytometry indicated that 2% of the host's splenocytes were expressing high levels of CD49 (alpha4 integrin of VLA-4) and low levels of CD11a (alphaL subunit of the integrin LFA-1).
Gene_expression (expressing) of integrin LFA-1
10) Confidence 0.45 Published 2005 Journal Ann Trop Med Parasitol Section Abstract Doc Link 16004711 Disease Relevance 0.50 Pain Relevance 0.08
These data suggest the existence of a LFA-1-activating environment that is selectively found in SF from RA patients.
Gene_expression (found) of LFA-1 associated with rheumatoid arthritis
11) Confidence 0.41 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7561125 Disease Relevance 1.10 Pain Relevance 0.52
In addition to reduced CD11a expression on the surface of CD3+ T-cells, binding of efalizumab also causes a reduced expression of other adhesion molecules, such as CD11b, L-selectin or ?
Gene_expression (expression) of CD11a in T-cells associated with adhesions
12) Confidence 0.40 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.60 Pain Relevance 0.14
While CD11a is expressed widely on leukocytes, expression of CD11b and CD11c was thought to be confined to cells of myeloid origin and these molecules have been used as markers to define certain cell populations, e.g.
Gene_expression (expressed) of CD11a in leukocytes
13) Confidence 0.33 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.15 Pain Relevance 0
However, it is known that the activated platelets express CD11a [16].
Gene_expression (express) of CD11a in platelets
14) Confidence 0.28 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 1.34 Pain Relevance 0.32
However, neither the level of apoptosis nor the expression of cell adhesion molecules such as LFA-1 and CD44 were altered in CNS-infiltrating T cells (Fig. 6A and data not shown).
Gene_expression (expression) of LFA-1 in T cells associated with central nervous system, apoptosis and adhesions
15) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 1.15 Pain Relevance 0.14
(145-2C11), anti-CD4 (RM4-5), anti-CD44 (IM7), anti-CD11a/LFA-1 (2D7), anti-IFN?
Gene_expression (anti) of LFA-1 in 145-2C11
16) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.21 Pain Relevance 0.13
(145-2C11), anti-CD4 (RM4-5), anti-CD44 (IM7), anti-CD11a/LFA-1 (2D7), anti-IFN?
Gene_expression (/) of LFA-1 in 145-2C11
17) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.20 Pain Relevance 0.13
In contrast, in only 1 or 2 out of 10 immunostainings performed for each CVO, were individual perivascular cells staining positive for macrophage markers such as F4/80 or Mac-1 or MHC class I or II and LFA-1 detected in CVOs of healthy mice (Table 1).
Gene_expression (detected) of LFA-1 in macrophage
18) Confidence 0.22 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.21 Pain Relevance 0
Surprisingly, defective expression of LFA-1 eliminates the capacity of microglial cells to migrate toward injured neurons [131].
Gene_expression (expression) of LFA-1 in neurons
19) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.48 Pain Relevance 0.08
Our mechanistic studies revealed that CpdA acts by down regulating expression of the cell adhesion molecules LFA-1 and CD44 on peripheral Th cells and by repressing IL-17 production by antigen-specific effector T cells.
Gene_expression (expression) of LFA-1 in effector T cells associated with adhesions
20) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.65 Pain Relevance 0.07

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