INT49406

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 8.58
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgal)
Anatomy Link Frequency
monocytes 2
lung 2
macrophages 1
neutrophils 1
T lymphocytes 1
Itgal (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 11 98.98 Very High Very High Very High
chemokine 40 97.28 Very High Very High Very High
cytokine 61 96.04 Very High Very High Very High
ischemia 35 89.20 High High
Angina 2 87.76 High High
spinal inflammation 1 68.64 Quite High
Osteoarthritis 1 67.68 Quite High
Pain 3 52.88 Quite High
Inflammatory response 21 51.80 Quite High
Inflammation 77 10.72 Low Low
Disease Link Frequency Relevance Heat
Stroke 84 99.32 Very High Very High Very High
Infection 221 99.12 Very High Very High Very High
Rheumatoid Arthritis 11 98.98 Very High Very High Very High
Mycobacterial Infection 290 98.84 Very High Very High Very High
Adhesions 33 97.96 Very High Very High Very High
Cytomegalovirus Infection 28 97.44 Very High Very High Very High
Myocardial Infarction 13 96.52 Very High Very High Very High
Cv Unclassified Under Development 21 89.20 High High
Cv General 3 Under Development 5 87.76 High High
Tick Infestations 3 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CD11a(lo) population of splenocytes from the tick-infested mice was positive for TER-119 but negative for CD3, B220, CD11b and Gr, confirming that the splenocytes were members of the erythroid lineage.
Positive_regulation (negative) of CD11a
1) Confidence 0.43 Published 2005 Journal Ann Trop Med Parasitol Section Abstract Doc Link 16004711 Disease Relevance 0.45 Pain Relevance 0.05
Accordingly, we found induction of transcripts encoding CD11a (ITGAL) and CD18 (ITGB2) on D21 in the M.tuberculosis infected lung (Table 5).
Positive_regulation (induction) of ITGAL in lung associated with mycobacterial infection and infection
2) Confidence 0.34 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.97 Pain Relevance 0
Furthermore, exposure of PB T lymphocytes, which showed a low avidity state of LFA-1, to whole SF from RA patients that was depleted of T lymphocytes could induce a high avidity state of LFA-1 in vitro.
Positive_regulation (induce) of LFA-1 in T lymphocytes associated with rheumatoid arthritis
3) Confidence 0.30 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7561125 Disease Relevance 1.15 Pain Relevance 0.58
Accordingly, we found induction of transcripts encoding CD11a (ITGAL) and CD18 (ITGB2) on D21 in the M.tuberculosis infected lung (Table 5).
Positive_regulation (induction) of CD11a in lung associated with mycobacterial infection and infection
4) Confidence 0.23 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.97 Pain Relevance 0
Due to upregulation of LFA-1 and Mac-1 after stroke, more neutrophils will adhere to the vessel wall and undergo the necessary conformational changes to cross the BBB [133].
Positive_regulation (upregulation) of LFA-1 in neutrophils associated with stroke
5) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.56 Pain Relevance 0.14
In addition, the increased monocyte CD11a was accompanied by an increased number of monocytes and a greater expression of CD11a per cell in the AMI group.
Positive_regulation (increased) of CD11a in monocytes associated with myocardial infarction
6) Confidence 0.05 Published 2004 Journal J. Atheroscler. Thromb. Section Abstract Doc Link 15067196 Disease Relevance 0.84 Pain Relevance 0.09
In addition, the increased monocyte CD11a was accompanied by an increased number of monocytes and a greater expression of CD11a per cell in the AMI group.
Positive_regulation (accompanied) of CD11a in monocytes associated with myocardial infarction
7) Confidence 0.04 Published 2004 Journal J. Atheroscler. Thromb. Section Abstract Doc Link 15067196 Disease Relevance 0.84 Pain Relevance 0.09
As shown in Fig 1, the levels of the expression of CD11a, CD11b and CD18 on macrophages were significantly upregulated in both groups after 4 h ventilation.
Positive_regulation (upregulated) of CD11a in macrophages
8) Confidence 0.02 Published 1998 Journal Crit Care Section Body Doc Link PMC29000 Disease Relevance 0.79 Pain Relevance 0

General Comments

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