INT49431

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Context Info
Confidence 0.82
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 31
Total Number 43
Disease Relevance 2.20
Pain Relevance 29.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
embryonic kidney 4
tail 2
terminal portion 2
neuronal 1
SH-SY5Y 1
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 1900 100.00 Very High Very High Very High
agonist 232 100.00 Very High Very High Very High
Enkephalin 120 100.00 Very High Very High Very High
narcan 18 100.00 Very High Very High Very High
antagonist 491 99.88 Very High Very High Very High
Morphine 125 99.76 Very High Very High Very High
substance P 11 99.66 Very High Very High Very High
Kinase C 32 98.90 Very High Very High Very High
orphanin 5 98.82 Very High Very High Very High
MU agonist 25 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 14 98.88 Very High Very High Very High
Pain 147 91.16 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

416 90.56 High High
Post Operative Pain 1 90.48 High High
Bordatella Infection 4 83.92 Quite High
Hyperalgesia 19 83.12 Quite High
Nociception 96 80.40 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

195 77.84 Quite High
Depression 1 31.00 Quite Low
Toxicity 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of two opioid agonists, [d-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) and morphine, to induce mu-opioid receptor (MOR) phosphorylation, desensitization, and internalization was examined in human embryonic kidney (HEK) 293 cells expressing rat MOR1 as well G protein-coupled inwardly rectifying potassium channel (GIRK) channel subunits.
Phosphorylation (phosphorylation) of mu-opioid receptor in embryonic kidney associated with mu agonist, potassium channel, opioid receptor, enkephalin and morphine
1) Confidence 0.82 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 0.94
The ability of two opioid agonists, [d-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) and morphine, to induce mu-opioid receptor (MOR) phosphorylation, desensitization, and internalization was examined in human embryonic kidney (HEK) 293 cells expressing rat MOR1 as well G protein-coupled inwardly rectifying potassium channel (GIRK) channel subunits.
Phosphorylation (phosphorylation) of MOR in embryonic kidney associated with mu agonist, potassium channel, opioid receptor, enkephalin and morphine
2) Confidence 0.82 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 0.94
The PKC inhibitor bisindolylmaleimide 1 (GF109203X) inhibited MOR1 phosphorylation under basal conditions and in the presence of morphine, but it did not inhibit DAMGO-induced phosphorylation.
Phosphorylation (phosphorylation) of MOR1 associated with kinase c and morphine
3) Confidence 0.82 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 1.59
Morphine and DAMGO enhanced MOR1 phosphorylation over basal.
Phosphorylation (phosphorylation) of MOR1 associated with morphine
4) Confidence 0.82 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 1.58
Cross-phosphorylation and cross-desensitization of the sst(2A)-MOR1 heterodimer were selective; they were neither observed with the sst(2A)-sst(3) heterodimer nor with the endogenously expressed lysophosphatidic acid receptor.
Phosphorylation (osphorylation a) of MOR1
5) Confidence 0.82 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.26
Similarly, exposure of the sst(2A)-MOR1 heterodimer to the mu-selective ligand [d-Ala(2),Me-Phe(4),Gly(5)-ol]enkephalin induced phosphorylation and desensitization of both MOR1 and sst(2A) but not internalization of sst(2A).
Phosphorylation (osphorylation a) of MOR1 associated with enkephalin
6) Confidence 0.82 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.30
However, exposure of the sst(2A)-MOR1 heterodimer to the sst(2A)-selective ligand L-779,976 induced phosphorylation, internalization, and desensitization of sst(2A) as well as MOR1.
Phosphorylation (phosphorylation) of MOR1
7) Confidence 0.81 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.31
Previously, we reported that the time course for the rapid phosphorylation rate of mu-opioid receptor expressed in human embryonic kidney (HEK)293 cells did not correlate with the slow receptor desensitization rate induced by [D-Ala(2),N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO).
Phosphorylation (phosphorylation) of mu-opioid receptor in embryonic kidney associated with enkephalin and opioid receptor
8) Confidence 0.79 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10908307 Disease Relevance 0 Pain Relevance 0.26
The results indicate that the Ser and Thr residues in the third cytoplasmic loop and C-terminus of the mu-opioid receptor are not involved in the limited desensitization or in the adenylyl cyclase superactivation promoted by agonists but that their integrity and/or their phosphorylation is required in the intricate and coordinately regulated pathways involved in receptor signaling and trafficking.
Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist and opioid receptor
9) Confidence 0.76 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9350996 Disease Relevance 0 Pain Relevance 0.70
However, in MOR/ mGluR5 co-expressing cells, the non-competitive mGluR5 antagonist MPEP (2-methyl-6-(phenyl-ethynyl)-pyridine) decreases the DAMGO-induced MOR phosphorylation, internalization, and desensitization, whereas non-selective competitive mGluR antagonists or agonists had no effects.
Phosphorylation (phosphorylation) of MOR associated with antagonist, agonist and opioid receptor
10) Confidence 0.76 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 1.02
To elucidate the relationship between mu-opioid receptor (MOR) phosphorylation and the regulation of receptor activity, a series of receptor mutants was constructed in which the 12 Ser/Thr residues of the COOH-terminal portion of the receptor were substituted to Ala, either individually or in combination.
Phosphorylation (phosphorylation) of mu-opioid receptor in terminal portion associated with opioid receptor
11) Confidence 0.70 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278523 Disease Relevance 0 Pain Relevance 0.21
The present data show that the basal phosphorylation of MOR could play a role in modulating agonist-induced receptor internalization kinetics.
Phosphorylation (phosphorylation) of MOR associated with agonist and opioid receptor
12) Confidence 0.70 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278523 Disease Relevance 0 Pain Relevance 0.56
To elucidate the relationship between mu-opioid receptor (MOR) phosphorylation and the regulation of receptor activity, a series of receptor mutants was constructed in which the 12 Ser/Thr residues of the COOH-terminal portion of the receptor were substituted to Ala, either individually or in combination.
Phosphorylation (phosphorylation) of MOR in terminal portion associated with opioid receptor
13) Confidence 0.70 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278523 Disease Relevance 0 Pain Relevance 0.21
The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation.
Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist, opioid receptor and enkephalin
14) Confidence 0.63 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 10092593 Disease Relevance 0.09 Pain Relevance 0.85
Thus, these data show that phosphorylation of MOR1TAG is not an obligatory event for the DAMGO-induced loss in the adenylyl cyclase regulation by the receptor.
Phosphorylation (phosphorylation) of MOR1TAG
15) Confidence 0.63 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10092593 Disease Relevance 0 Pain Relevance 0.39
Protein kinase C can phosphorylate the receptor, but is not involved in DAMGO-induced MOR1TAG phosphorylation.
Phosphorylation (phosphorylation) of MOR1TAG associated with kinase c
16) Confidence 0.63 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10092593 Disease Relevance 0.09 Pain Relevance 0.69
Our results provide substantial evidence that the 6TM MOR1K isoform is not just another alternatively-spliced form of MOR1, but instead it represents a functional receptor that contributes to the net cellular response of MOR agonists by facilitating excitatory effects.
Phosphorylation (form) of MOR1 associated with agonist and opioid receptor
17) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0.46 Pain Relevance 1.42
DAMGO stimulated a threefold increase in MOR1 phosphorylation within 20 min that could be reversed by the antagonist naloxone.
Phosphorylation (phosphorylation) of MOR1 associated with antagonist, narcan and opioid receptor
18) Confidence 0.63 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.67
MOR1 itself, however, appears to be a poor substrate for MAPK because mu-receptors immunoprecipitated from stably transfected HEK 293 cells were not phosphorylated by exogenous ERK 2 in vitro.
Neg (not) Phosphorylation (phosphorylated) of MOR1 in HEK associated with opioid receptor
19) Confidence 0.62 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.83
Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization.
Phosphorylation (Phosphorylation) of mu-opioid receptor in tail associated with opioid receptor
20) Confidence 0.47 Published 2001 Journal J. Biol. Chem. Section Title Doc Link 11278523 Disease Relevance 0 Pain Relevance 0.35

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