INT49433

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Context Info
Confidence 0.02
First Reported 1995
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.26
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PTPRM) cell adhesion (PTPRM) cytoplasm (PTPRM)
Anatomy Link Frequency
brain 2
PTPRM (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 10 98.96 Very High Very High Very High
Morphine 3 98.76 Very High Very High Very High
Potency 6 96.88 Very High Very High Very High
Enkephalin 4 94.76 High High
Pain 12 94.00 High High
opioid receptor 11 90.32 High High
analgesia 3 88.16 High High
orphanin 3 83.64 Quite High
mu opioid receptor 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 3 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second messenger assays further indicate that formation of ORL1/muR heterodimer selectively induces cross-desensitization of muR and impairs the potency by which [D-Ala(2),N-methyl-Phe(4),Gly-ol(5)]enkephalin (DAMGO) inhibits adenylate cyclase and stimulates p42/p44 mitogen-activated protein kinase (MAPK) phosphorylation.
muR Binding (formation) of associated with enkephalin and potency
1) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.07 Pain Relevance 0.53
Thus, it is hypothesized that ORL1 and muR interact to form the heterodimer and that ORL1/muR heterodimerization may be one molecular basis for ORL1-mediated antiopioid effects in the brain.
muR Binding (interact) of in brain
2) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.09 Pain Relevance 0.49
Thus, it is hypothesized that ORL1 and muR interact to form the heterodimer and that ORL1/muR heterodimerization may be one molecular basis for ORL1-mediated antiopioid effects in the brain.
muR Binding (heterodimerization) of in brain
3) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.09 Pain Relevance 0.54
In conclusion, intracellular trafficking of the muR appears to depend on the agonist, with morphine and DAMGO having markedly different effects.
muR Binding (trafficking) of associated with agonist and morphine
4) Confidence 0.02 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7561859 Disease Relevance 0 Pain Relevance 0.59

General Comments

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