INT49437

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Context Info
Confidence 0.54
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 20.12
Pain Relevance 7.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cartilage 3
chondrocyte 2
knee 2
hip 1
temporomandibular joint 1
OAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 935 100.00 Very High Very High Very High
Snapping jaw 4 100.00 Very High Very High Very High
Inflammation 235 99.16 Very High Very High Very High
metalloproteinase 15 99.08 Very High Very High Very High
Pain 80 98.76 Very High Very High Very High
cytokine 239 97.92 Very High Very High Very High
imagery 67 92.56 High High
Arthritis 12 90.20 High High
anesthesia 35 89.04 High High
Crohn's disease 35 88.84 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 897 100.00 Very High Very High Very High
Hip Osteoarthritis 45 100.00 Very High Very High Very High
Frailty 37 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 4 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 215 99.98 Very High Very High Very High
Hypertrophy 25 99.62 Very High Very High Very High
INFLAMMATION 216 99.16 Very High Very High Very High
Lung Injury 110 99.16 Very High Very High Very High
Pain 76 98.76 Very High Very High Very High
Disease 267 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig. 1, the highest percentage of overweight or obese patients was found in the age ranges 50–59 and 60–69 years, the average age at which hip OA is generally expected to occur in any population.
Gene_expression (expected) of OA in hip associated with obesity, osteoarthritis and overweight
1) Confidence 0.54 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.56 Pain Relevance 0.13
In this study we used a quantitative comparison of X-ray images to analyze the progression of OA and the differences between the KL grades.
Spec (analyze) Gene_expression (progression) of OA associated with osteoarthritis
2) Confidence 0.45 Published 2010 Journal J: Section Body Doc Link PMC2909716 Disease Relevance 0.61 Pain Relevance 0.20
The “gold standard” for this study is the KL grades, which can be subjective, and not necessarily an accurate quantitative reflection of the actual progression of OA.
Gene_expression (progression) of OA associated with osteoarthritis
3) Confidence 0.45 Published 2010 Journal J: Section Body Doc Link PMC2909716 Disease Relevance 0.90 Pain Relevance 0.33
In this study we apply the wndchrm tool to the assessment of the progression of OA, but it should be noted that wndchrm is a general-purpose biomedical image analysis tool and can provide an informative analysis for a variety of subjects, magnifications, and types of imaging [29].
Gene_expression (progression) of OA associated with imagery and osteoarthritis
4) Confidence 0.45 Published 2010 Journal J: Section Body Doc Link PMC2909716 Disease Relevance 0.98 Pain Relevance 0.42
These findings suggest that the KL scale might not be linear to the actual progression of OA and also indicate that understanding the mechanisms of the disease might require the analysis of changes between KL grade 1 to KL grade 2.
Gene_expression (progression) of OA associated with disease and osteoarthritis
5) Confidence 0.45 Published 2010 Journal J: Section Body Doc Link PMC2909716 Disease Relevance 0.72 Pain Relevance 0.23
It should be noted that while the Kellgren-Lawrence classification is the most commonly used classification scheme, there is no scientific evidence that the KL system provides an accurate direct assessment of the progression of OA [6, 7].
Gene_expression (progression) of OA associated with osteoarthritis
6) Confidence 0.45 Published 2010 Journal J: Section Body Doc Link PMC2909716 Disease Relevance 0.97 Pain Relevance 0.29
An alternative way to diagnose and evaluate the progression of OA is by applying quantitative image analysis methods that can measure subtle changes in the bone structure, which have been correlated with biochemical, biomechanical, and structural alterations of the articular cartilage and the subchondral bone tissues [11, 12] associated with cartilage degeneration [13, 14].
Gene_expression (progression) of OA in articular cartilage associated with osteoarthritis
7) Confidence 0.45 Published 2010 Journal J: Section Body Doc Link PMC2909716 Disease Relevance 0.44 Pain Relevance 0.15
Our unique RCT is targeting PFJ OA, an important sub-group of knee OA, with a specifically designed intervention.
Gene_expression (targeting) of PFJ OA in knee associated with osteoarthritis
8) Confidence 0.37 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2556332 Disease Relevance 1.11 Pain Relevance 0.80
As we have seen, OS hypothesises the existence of three operational levels in linguistic thought, which can be related to OMs of different complexity in the OA framework:
Gene_expression (framework) of OA
9) Confidence 0.26 Published 2010 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2948146 Disease Relevance 0 Pain Relevance 0
Let us briefly observe the main postulates of the OA framework:
Gene_expression (framework) of OA
10) Confidence 0.26 Published 2010 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2948146 Disease Relevance 0.12 Pain Relevance 0
As our intent was to investigate subjects with no significant current or past knee disease, individuals were excluded if they had had any of the following: a clinical diagnosis of knee OA as defined by American College of Rheumatology criteria, knee pain lasting for > 24 h in the last 5 years, a previous knee injury requiring non-weight bearing treatment for > 24 h or surgery (including arthroscopy), or a history of any form of arthritis diagnosed by a medical practitioner.
Gene_expression (diagnosis) of OA in knee associated with pain, knee injuries, disease, osteoarthritis and arthritis
11) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 0.93 Pain Relevance 0.23
M EPA), while the total molarity of fatty acids supplied was similar in all experiments by adding OA.
Gene_expression (adding) of OA
12) Confidence 0.08 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.41 Pain Relevance 0.16
These relatively low concentrations of OA (160 ?
Gene_expression (concentrations) of OA
13) Confidence 0.08 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.06 Pain Relevance 0
M OA [C18:1(n-9)] versus 130 ?
Gene_expression ([C18:1) of OA
14) Confidence 0.08 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.08 Pain Relevance 0.05
ANOVA between groups, non-stimulated P < 0.001, stimulated P = 0.006 and net stimulated P = 0.134. aBonferroni P < 0.05 versus OA and EPA non-stimulated, bBonferroni P < 0.05 versus OA and EPA cytokine stimulatedFig. 4NF-?
Gene_expression (non) of OA associated with cytokine
15) Confidence 0.08 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0 Pain Relevance 0.17
Despite these clear differences in non-stimulated and stimulated ICAM-1 expression between ARA and EPA or OA, the net stimulated ICAM-1 expression did not differ between the groups (ANOVA P = 0.134).
Gene_expression (expression) of OA
16) Confidence 0.07 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.08 Pain Relevance 0
L: microlitres; ml.Kg-1: mililiters per kilogram; min: minutes; OA: Oleic acid; PO2: Partial pressure of Oxygen; SEM: Standard error of the mean; TNF-?
Gene_expression (minutes) of OA
17) Confidence 0.05 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 0.99 Pain Relevance 0
The ALI produced by OA is relatively transient, and resolves over several hours [10].
Gene_expression (produced) of OA associated with adult respiratory distress syndrome
18) Confidence 0.05 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 2.15 Pain Relevance 0.13
l of OA was determined to produce a significant early lung injury over a 4 h period.
Gene_expression (produce) of OA in lung associated with lung injury
19) Confidence 0.05 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 0.85 Pain Relevance 0.35
L: microlitres; ml.Kg-1: mililiters per kilogram; min: minutes; OA: Oleic acid; PO2: Partial pressure of Oxygen; SEM: Standard error of the mean; TNF-?
Gene_expression (pressure) of OA
20) Confidence 0.05 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 0.99 Pain Relevance 0

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