INT49439

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Context Info
Confidence 0.73
First Reported 1995
Last Reported 2011
Negated 14
Speculated 13
Reported most in Abstract
Documents 508
Total Number 530
Disease Relevance 326.97
Pain Relevance 130.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
brain 23
muscle tissue 14
dorsal root ganglia 14
microglia 8
neuronal 6
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 5073 100.00 Very High Very High Very High
cytokine 2010 100.00 Very High Very High Very High
COX-2 inhibitor 1340 100.00 Very High Very High Very High
cerebral cortex 668 100.00 Very High Very High Very High
Central nervous system 480 100.00 Very High Very High Very High
gABA 375 100.00 Very High Very High Very High
chemokine 250 100.00 Very High Very High Very High
cOX1 113 100.00 Very High Very High Very High
Paracetamol 150 99.92 Very High Very High Very High
Arthritis 148 99.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 7605 100.00 Very High Very High Very High
INFLAMMATION 6617 100.00 Very High Very High Very High
Targeted Disruption 2386 100.00 Very High Very High Very High
Colon Cancer 1740 100.00 Very High Very High Very High
Pressure And Volume Under Development 153 100.00 Very High Very High Very High
Pancreatic Cancer 2684 99.96 Very High Very High Very High
Breast Cancer 642 99.96 Very High Very High Very High
Disease 5871 99.92 Very High Very High Very High
Adenoma 630 99.92 Very High Very High Very High
Stress 900 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COX-1 is constitutively expressed, whereas COX-2 is induced by proinflammatory stimuli.
Gene_expression (expressed) of COX
1) Confidence 0.73 Published 1999 Journal Anal. Biochem. Section Abstract Doc Link 10361000 Disease Relevance 0.15 Pain Relevance 0.25
Cyclo-oxygenase (COX) is the rate-limiting enzyme in the production of prostaglandins and, as such, is a key target for many anti-inflammatory drugs.
Gene_expression (production) of COX associated with inflammation and cinod
2) Confidence 0.65 Published 2005 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16026518 Disease Relevance 0.78 Pain Relevance 0.24
Oral administration with a specific COX-2 or a nonspecific COX inhibitors lowered the expression of potent angiogenic factors; vascular endothelial growth factor and basic fibroblast growth factor, reduced angiogenesis and growth, induced apoptosis, and suppressed cell replication of the COX-2 overexpressing cancer xenografts in a dose-dependent manner.
Gene_expression (overexpressing) of COX in fibroblast associated with cancer and apoptosis
3) Confidence 0.61 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.82 Pain Relevance 0.10
To clarify the roles of cyclooxygenase (COX) in malignant tumor development and angiogenesis, we investigated the effects of COX inhibitors on two kinds of gastrointestinal cancer xenograft, one of which overexpresses COX-2 and the other expresses no COX, in nude mice in vivo.
Gene_expression (overexpresses) of COX associated with malignant neoplastic disease and gastrointestinal neoplasms
4) Confidence 0.61 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.64 Pain Relevance 0.03
The development of cyclooxygenase (COX) deficient mice has allowed investigation into the individual physiological roles of the COX-1 and COX-2 isoforms.
Gene_expression (roles) of COX
5) Confidence 0.59 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10487525 Disease Relevance 0.24 Pain Relevance 0.04
The development of cyclooxygenase (COX) deficient mice has allowed investigation into the individual physiological roles of the COX-1 and COX-2 isoforms.
Gene_expression (roles) of COX
6) Confidence 0.59 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10487525 Disease Relevance 0.24 Pain Relevance 0.09
The development of cyclooxygenase (COX) deficient mice has allowed investigation into the individual physiological roles of the COX-1 and COX-2 isoforms.
Gene_expression (roles) of COX
7) Confidence 0.59 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10487525 Disease Relevance 0.24 Pain Relevance 0.04
MATERIALS AND METHODS: Since the major mechanism of action attributed to aspirin is the inhibition of cyclooxygenase (COX), prostaglandin (PG) production was examined under differentiation-inducing conditions in MEL cells.
Spec (examined) Gene_expression (production) of COX
8) Confidence 0.57 Published 2003 Journal Anticancer Res. Section Body Doc Link 12680248 Disease Relevance 0.09 Pain Relevance 0
Despite the utility of cyclooxygenase (COX) inhibition as an antiinflammatory strategy, prostaglandin (PG) products of COX-1 and -2 provide important regulatory functions in some pathophysiological states.
Gene_expression (products) of COX associated with inflammation
9) Confidence 0.50 Published 2001 Journal Chem. Res. Toxicol. Section Abstract Doc Link 11743745 Disease Relevance 0.37 Pain Relevance 0.22
Cyclooxygenase (COX) enzyme expression is elevated in human and rodent lung tumors, and non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin reduce lung tumor formation in mice.
Gene_expression (expression) of COX in lung associated with inflammation, lung cancer and cinod
10) Confidence 0.49 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12376474 Disease Relevance 0.58 Pain Relevance 0.34
Prostacyclin I2, predominantly a product of COX-2, is a vasodilator that inhibits platelet aggregation and smooth muscle proliferation, effects that might be expected to reduce acute coronary syndromes and stroke.
Gene_expression (product) of COX in smooth muscle associated with acute coronary syndrome and stroke
11) Confidence 0.47 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584256 Disease Relevance 0.38 Pain Relevance 0.21
Estrogen increases expression of COX-2 and production of prostacyclin I2, effects that have been proposed to underlie its apparent cardioprotective effects in animal models [28].
Gene_expression (expression) of COX
12) Confidence 0.47 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584256 Disease Relevance 0.28 Pain Relevance 0.31
Thromboxane A2, produced by COX-1 in platelets, is a vasoconstrictor that stimulates platelet aggregation, an effect that might be expected to increase cardiovascular risk.
Gene_expression (produced) of COX in platelet
13) Confidence 0.47 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584256 Disease Relevance 0.32 Pain Relevance 0.28
A nonspecific COX inhibitor, not a specific COX-2 inhibitor, reduced growth and angiogenesis of non-COX expressing cancer xenograft by inhibition of COX-1 in vascular endothelial cells.
Gene_expression (expressing) of COX in endothelial cells associated with cancer and cox-2 inhibitor
14) Confidence 0.46 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.82 Pain Relevance 0.12
Two possible sites have been postulated for the antipyretic action of non-steroid anti-inflammatory drugs; (a) inhibition of COX in endothelial cells of hypothalamic blood vessels or (b) inhibition of COX synthesising prostaglandins near sensory receptors of sub-diaphragmatic vagal afferents.
Gene_expression (synthesising) of COX in blood vessels associated with inflammation and cinod
15) Confidence 0.44 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592546 Disease Relevance 0.52 Pain Relevance 1.00
COX has two isoforms: COX-1, the constitutively expressed form, and COX-2, the inducible form.
Gene_expression (expressed) of COX
16) Confidence 0.44 Published 2000 Journal Virology Section Abstract Doc Link 11021993 Disease Relevance 0.31 Pain Relevance 0.31
COX has two isoforms: COX-1, the constitutively expressed form, and COX-2, the inducible form.
Gene_expression (expressed) of COX
17) Confidence 0.44 Published 2000 Journal Virology Section Abstract Doc Link 11021993 Disease Relevance 0.32 Pain Relevance 0.31
To clarify the roles of cyclooxygenase (COX) in malignant tumor development and angiogenesis, we investigated the effects of COX inhibitors on two kinds of gastrointestinal cancer xenograft, one of which overexpresses COX-2 and the other expresses no COX, in nude mice in vivo.
Neg (no) Gene_expression (expresses) of COX associated with malignant neoplastic disease and gastrointestinal neoplasms
18) Confidence 0.41 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.65 Pain Relevance 0.03
COX enzymes exist in an inducible form COX-2, that has been found to be elevated in the AD brain, and a constitutive form COX-1.
Gene_expression (exist) of COX in brain associated with disease
19) Confidence 0.41 Published 2002 Journal J. Alzheimers Dis. Section Abstract Doc Link 12446975 Disease Relevance 1.50 Pain Relevance 0.75
Several studies support a role of COX products in the central nervous system response to infectious stimuli.
Gene_expression (products) of COX in central nervous system associated with central nervous system
20) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 1.24 Pain Relevance 0.26

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