INT49441

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2011
Negated 4
Speculated 12
Reported most in Abstract
Documents 494
Total Number 509
Disease Relevance 303.22
Pain Relevance 177.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
brain 13
colon 8
macrophages 7
dopaminergic neurons 7
skin 7
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 1851 100.00 Very High Very High Very High
COX-2 inhibitor 1399 100.00 Very High Very High Very High
COX2 248 100.00 Very High Very High Very High
Pain 239 100.00 Very High Very High Very High
cOX1 152 100.00 Very High Very High Very High
antagonist 136 100.00 Very High Very High Very High
Inflammatory mediators 100 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
cINOD 4104 99.98 Very High Very High Very High
Inflammation 3492 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4759 100.00 Very High Very High Very High
Pancreatic Cancer 1394 100.00 Very High Very High Very High
Pain 219 100.00 Very High Very High Very High
Cancer 4466 99.96 Very High Very High Very High
Disease 3370 99.96 Very High Very High Very High
Fever 240 99.96 Very High Very High Very High
Arthritis 99 99.96 Very High Very High Very High
Pneumonia 6 99.96 Very High Very High Very High
Breast Cancer 503 99.92 Very High Very High Very High
Metastasis 287 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Racemic ketoprofen has an antinociceptive activity which is probably not only due to COX inhibition but also involves noradrenergic systems at spinal and supraspinal levels.
Negative_regulation (inhibition) of COX in spinal associated with antinociceptive
1) Confidence 0.59 Published 2001 Journal Inflammation Section Abstract Doc Link 11580099 Disease Relevance 0.17 Pain Relevance 0.55
These results thus provide strong support for the notion that COX inhibition is a major determinant in the antitumorigenic effect of indomethacin in vivo.
Negative_regulation (inhibition) of COX
2) Confidence 0.57 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11239499 Disease Relevance 0.54 Pain Relevance 0.11
A key question is whether NSAIDs (excluding sulindac) exert their anticarcinogenic effects in vivo by a mechanism that is dependent on their capacity to inhibit COX activity.
Negative_regulation (inhibit) of COX associated with cinod
3) Confidence 0.57 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11239499 Disease Relevance 0.47 Pain Relevance 0.51
In conclusion, the results of the present study strongly suggest that COX plays an important role in the pathophysiology of PTZ-induced kindling in mice and that COX inhibitors could be a useful neuroprotective strategy for the treatment of epilepsy.
Negative_regulation (inhibitors) of COX associated with epilepsy
4) Confidence 0.57 Published 2005 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16026518 Disease Relevance 0.28 Pain Relevance 0
However, for the maintenance of normal physiology, it appears that deficiency of COX-2 has more profound effects than deficiency of COX-1.
Spec (appears) Negative_regulation (deficiency) of COX
5) Confidence 0.51 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10487525 Disease Relevance 0.32 Pain Relevance 0.13
Additionally, when the data permit, the effects of genetic ablation of COX activity are compared with those of pharmacological inhibition of COX activity by nonsteroidal anti-inflammatory drugs.
Negative_regulation (inhibition) of COX associated with inflammation and cinod
6) Confidence 0.51 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10487525 Disease Relevance 0.34 Pain Relevance 0.14
These mutations resulted in the absence or a dramatic decrease of CPO activity.
Negative_regulation (decrease) of CPO
7) Confidence 0.46 Published 1999 Journal Hum. Mutat. Section Abstract Doc Link 9888388 Disease Relevance 0.38 Pain Relevance 0.06
A nonspecific COX inhibitor, not a specific COX-2 inhibitor, reduced growth and angiogenesis of non-COX expressing cancer xenograft by inhibition of COX-1 in vascular endothelial cells.
Negative_regulation (inhibitor) of COX in endothelial cells associated with cancer and cox-2 inhibitor
8) Confidence 0.46 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.82 Pain Relevance 0.11
A nonspecific COX inhibitor, not a specific COX-2 inhibitor, reduced growth and angiogenesis of non-COX expressing cancer xenograft by inhibition of COX-1 in vascular endothelial cells.
Negative_regulation (inhibition) of COX in endothelial cells associated with cancer and cox-2 inhibitor
9) Confidence 0.46 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.81 Pain Relevance 0.12
These findings suggest that COX-2-derived mediators serve an important hepato-protective function and that COX inhibition may contribute to the risk of drug-induced liver injury, possibly through both nonimmunological and immunological pathways.
Negative_regulation (inhibition) of COX in liver associated with injury
10) Confidence 0.44 Published 2001 Journal Chem. Res. Toxicol. Section Abstract Doc Link 11743745 Disease Relevance 0.80 Pain Relevance 0.19
Despite the utility of cyclooxygenase (COX) inhibition as an antiinflammatory strategy, prostaglandin (PG) products of COX-1 and -2 provide important regulatory functions in some pathophysiological states.
Negative_regulation (inhibition) of COX associated with inflammation
11) Confidence 0.44 Published 2001 Journal Chem. Res. Toxicol. Section Abstract Doc Link 11743745 Disease Relevance 0.35 Pain Relevance 0.20
Scattered reports suggest that COX inhibition may also promote adverse drug events.
Negative_regulation (inhibition) of COX
12) Confidence 0.44 Published 2001 Journal Chem. Res. Toxicol. Section Abstract Doc Link 11743745 Disease Relevance 0.45 Pain Relevance 0.25
In the present study, we investigated the effects of etodolac, a selective COX-2 inhibitor, on mechanical allodynia in mice after partial sciatic nerve ligation (PSNL) compared to indomethacin (a nonselective COX inhibitor) or celecoxib (a selective COX-2 inhibitor).
Negative_regulation (inhibitor) of COX in sciatic nerve associated with allodynia, sciatic nerve and cox-2 inhibitor
13) Confidence 0.41 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19346674 Disease Relevance 0.68 Pain Relevance 0.95
These findings suggest that the mechanisms of inhibition of mechanical allodynia by etodolac and pregabalin are different and demonstrate that in contrast to other COX inhibitors, etodolac is effective against mechanical allodynia in a mouse neuropathic pain model.
Negative_regulation (inhibitors) of COX associated with pregabalin, allodynia and neuropathic pain
14) Confidence 0.41 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19346674 Disease Relevance 0.77 Pain Relevance 1.16
Two possible sites have been postulated for the antipyretic action of non-steroid anti-inflammatory drugs; (a) inhibition of COX in endothelial cells of hypothalamic blood vessels or (b) inhibition of COX synthesising prostaglandins near sensory receptors of sub-diaphragmatic vagal afferents.
Negative_regulation (inhibition) of COX in blood vessels associated with inflammation and cinod
15) Confidence 0.38 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592546 Disease Relevance 0.52 Pain Relevance 1.00
The antipyretic action of aspirin may be mediated by inhibition of COX-3 in hypothalamic endothelial cells or by inhibition of COX-1 localised close to sensory receptors of peripheral vagal afferents.
Negative_regulation (inhibition) of COX in endothelial cells associated with aspirin
16) Confidence 0.38 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592546 Disease Relevance 0.51 Pain Relevance 0.94
This effect was not seen in all NSAIDs and seems not to be mediated by inhibition of cyclooxygenase (COX) activity, the principal pharmacological target of NSAIDs.
Negative_regulation (inhibition) of COX associated with cinod
17) Confidence 0.38 Published 2001 Journal Nature Section Abstract Doc Link 11700559 Disease Relevance 0.48 Pain Relevance 0.81
However, for the maintenance of normal physiology, it appears that deficiency of COX-2 has more profound effects than deficiency of COX-1.
Negative_regulation (deficiency) of COX
18) Confidence 0.38 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10487525 Disease Relevance 0.31 Pain Relevance 0.13
Considerable research effort is currently being directed towards understanding the mechanisms mediating the antiproliferative effects of non-steroidal anti-inflammatory drugs (NSAIDs) and, more recently, of cyclooxygenase (COX)-2 inhibitors as well.
Negative_regulation (inhibitors) of COX associated with inflammation and cinod
19) Confidence 0.37 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11239499 Disease Relevance 0.38 Pain Relevance 0.43
Significantly, similar results were seen when indomethacin was given in vivo at the low dose of 2 mg per kg/day, which blocked blood platelet COX activity and at the same time produced a delay in tumor growth initiation and attenuation of apparent primary tumor growth as well as growth of lung metastases.
Negative_regulation (blocked) of COX in lung associated with cancer and metastasis
20) Confidence 0.37 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11239499 Disease Relevance 0.63 Pain Relevance 0.18

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