INT49448

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Context Info
Confidence 0.38
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
neurons 2
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 14 100.00 Very High Very High Very High
Dopamine 8 99.84 Very High Very High Very High
cocaine 2 99.72 Very High Very High Very High
Nucleus accumbens 4 96.56 Very High Very High Very High
dexamethasone 6 84.80 Quite High
agonist 6 77.52 Quite High
opioid receptor 2 73.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucocorticoid receptor activation potentiates the morphine-induced adaptive increase in dopamine D-1 receptor efficacy in gamma-aminobutyric acid neurons of rat striatum/nucleus accumbens.
Positive_regulation (increase) of Positive_regulation (activation) of Glucocorticoid receptor in neurons associated with nucleus accumbens, dopamine and morphine
1) Confidence 0.38 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7562482 Disease Relevance 0 Pain Relevance 0.65
These data show that the morphine-induced adaptive increase of postsynaptic dopamine D-1 receptor efficacy (also observed in striatal slices of rats weeks after repeated treatment with morphine or cocaine) is strongly enhanced after previous or simultaneous glucocorticoid receptor activation.
Positive_regulation (enhanced) of Positive_regulation (activation) of glucocorticoid receptor associated with dopamine, cocaine and morphine
2) Confidence 0.30 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562482 Disease Relevance 0 Pain Relevance 0.90

General Comments

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