INT49454

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Context Info
Confidence 0.08
First Reported 1994
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 9.99
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
fibroblast 4
liver 2
spinal cord 2
platelet 2
neuronal 2
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 5 99.68 Very High Very High Very High
Hippocampus 12 99.54 Very High Very High Very High
Nerve growth factor 5 98.48 Very High Very High Very High
melanocortin 1 receptor 1 93.88 High High
antagonist 33 93.60 High High
B1 receptor 34 93.12 High High
Neuropathic pain 3 92.20 High High
Inflammation 73 89.88 High High
cytokine 92 87.08 High High
Sciatic nerve 1 86.72 High High
Disease Link Frequency Relevance Heat
Cancer 104 100.00 Very High Very High Very High
Necrosis 11 100.00 Very High Very High Very High
Microphthalmia 3 100.00 Very High Very High Very High
Apoptosis 20 99.40 Very High Very High Very High
Lifespan 48 99.32 Very High Very High Very High
Targeted Disruption 62 98.98 Very High Very High Very High
Injury 130 98.68 Very High Very High Very High
Colorectal Cancer 1 96.32 Very High Very High Very High
Disease 14 95.92 Very High Very High Very High
Metastasis 20 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sinomenine protected against the hepatic injuries in the dose range of 10-100 mg/kg in a dose-dependent manner and suppressed the production of tumor necrosis factor (TNF), which appeared in serum earlier than aminotransferases in GalN/LPS-treated mice.
Negative_regulation (suppressed) of Gene_expression (production) of factor associated with necrosis, cancer and injury
1) Confidence 0.08 Published 1994 Journal Biochem. Pharmacol. Section Abstract Doc Link 8093093 Disease Relevance 0.47 Pain Relevance 0
Oral administration with a specific COX-2 or a nonspecific COX inhibitors lowered the expression of potent angiogenic factors; vascular endothelial growth factor and basic fibroblast growth factor, reduced angiogenesis and growth, induced apoptosis, and suppressed cell replication of the COX-2 overexpressing cancer xenografts in a dose-dependent manner.
Negative_regulation (lowered) of Gene_expression (expression) of factor in fibroblast associated with cancer and apoptosis
2) Confidence 0.07 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.82 Pain Relevance 0.04
Oral administration with a specific COX-2 or a nonspecific COX inhibitors lowered the expression of potent angiogenic factors; vascular endothelial growth factor and basic fibroblast growth factor, reduced angiogenesis and growth, induced apoptosis, and suppressed cell replication of the COX-2 overexpressing cancer xenografts in a dose-dependent manner.
Negative_regulation (lowered) of Gene_expression (expression) of factor in fibroblast associated with cancer and apoptosis
3) Confidence 0.07 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.81 Pain Relevance 0.04
The same repeated treatment inhibited tumor necrosis factor (TNFalpha) overproduction in the spinal cord and increased the NGF support.
Negative_regulation (inhibited) of Gene_expression (overproduction) of factor in spinal cord associated with necrosis, nerve growth factor, cancer and spinal cord
4) Confidence 0.07 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20399204 Disease Relevance 1.49 Pain Relevance 0.96
Connolly et al. proposed that in vitro COX inhibitors decreased vascular endothelial growth factor production and increased apoptosis of tumor cells, as well as a reduced primary tumor weight, the number of lung metastases, and microvessel density in primary tumors in mice [28].
Negative_regulation (decreased) of Gene_expression (production) of factor in lung associated with cancer, apoptosis and metastasis
5) Confidence 0.02 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2621123 Disease Relevance 1.43 Pain Relevance 0.33
In fact, reduced IGF-I levels in circulation may be the main factor behind extended lifespan in dwarf mice, such that with respect to liver, the only expression change consequential for longevity determination is that of the IGF-I transcript.
Negative_regulation (reduced) of Gene_expression (levels) of factor in liver associated with aging and lifespan
6) Confidence 0.02 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.91 Pain Relevance 0
Downregulation of melanocyte differentiation markers mRNAs was preceded by a decrease in microphthalmia transcription factor (Mitf) gene expression, which was quantitatively similar to the decrease achieved using 12-O-tetradecanoylphorbol-13-acetate.
Negative_regulation (decrease) of Gene_expression (expression) of factor in melanocyte associated with microphthalmia
7) Confidence 0.02 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11493672 Disease Relevance 0.39 Pain Relevance 0.09
Serum levels of IgM-rheumatoid factor (RF) decreased significantly at 24 weeks and anti-citrullinated peptide antibody (ACPA) levels at 36 weeks.
Negative_regulation (decreased) of Gene_expression (levels) of factor
8) Confidence 0.02 Published 2008 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC2564787 Disease Relevance 0.33 Pain Relevance 0.16
SB 203347 inhibited A23187-induced intact human neutrophil AA mass release in a concentration-dependent manner (IC50 = 1 microM), which coincided with reductions in the biosynthesis of platelet-activating factor (IC50 = 1.5 microM) and leukotriene B4 (IC50 = 2.3 microM).
Negative_regulation (reductions) of Gene_expression (biosynthesis) of factor in platelet
9) Confidence 0.02 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562496 Disease Relevance 0.29 Pain Relevance 0.13
Prior microarray studies of the sensory ganglia of Brn3a knockout mice have revealed transcripts both increased and decreased in the absence of this factor [13,26].
Negative_regulation (decreased) of Neg (absence) Gene_expression (absence) of factor in ganglia associated with targeted disruption
10) Confidence 0.02 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.58 Pain Relevance 0.03
Indeed culturing neural cells of different origins under neurosphere conditions has been shown to induce a partial loss of region-specific transcription factor expression while resulting in the up-regulation of Olig2 and Mash1 [34], providing a more permissive transcriptional environment that favours reprogramming towards distinct neuronal subtypes.
Spec (partial) Negative_regulation (loss) of Gene_expression (expression) of factor in neuronal
11) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.06 Pain Relevance 0.09
Microarray analyses of HOXA3-treated wounds revealed that indeed HOXA3 locally increased expression of genes that selectively promote stem/progenitor cell mobilization and recruitment while also suppressing expression of numerous members of the proinflammatory nuclear factor ?
Negative_regulation (suppressing) of Gene_expression (expression) of factor in stem associated with injury
12) Confidence 0.01 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Abstract Doc Link PMC2733377 Disease Relevance 0.85 Pain Relevance 0.04
Administration of SSR240612 also prevented an increase in number of activated microglial cells in mouse hippocampus, but did not affect a reduction in expression of mRNA for brain-derived neurotrophic factor.
Negative_regulation (reduction) of in brain Gene_expression (expression) of factor in microglial cells associated with hippocampus
13) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC3022820 Disease Relevance 0.59 Pain Relevance 0.45
This results in reduced expression of the transcription factor IRF-1, which is crucial for induction of iNOS [440].
Negative_regulation (reduced) of Gene_expression (expression) of factor
14) Confidence 0.01 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.99 Pain Relevance 0.07

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