INT49464

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.50
Pain Relevance 6.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dpys) cytoplasm (Dpys)
Anatomy Link Frequency
brain 2
dorsal 1
sciatic nerve 1
cortex 1
Dpys (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 10 99.58 Very High Very High Very High
Sciatic nerve 2 99.56 Very High Very High Very High
Kinase C 8 99.44 Very High Very High Very High
tolerance 34 99.34 Very High Very High Very High
cerebral cortex 2 99.28 Very High Very High Very High
Opioid 22 99.26 Very High Very High Very High
tetrodotoxin 2 99.10 Very High Very High Very High
Spinal cord 4 98.60 Very High Very High Very High
Central grey 4 98.08 Very High Very High Very High
Raphe 4 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 4 93.04 High High
Paralysis 2 91.72 High High
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated cAMP levels specifically inhibited the expression of RY receptor mRNA while 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C, increased the transcripts encoding the RY receptor and the alpha 1 subunit of the DHP receptor.
Positive_regulation (encoding) of DHP associated with kinase c
1) Confidence 0.47 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7592768 Disease Relevance 0.07 Pain Relevance 0.29
U50,488H (25 mg/kg, i.p.) and NIM (1 mg/kg, i.p.) twice daily for 4 days also resulted in an equivalent up-regulation of DHP binding sites (+36%) as that of U50,488H alone.
Positive_regulation (up-regulation) of DHP
2) Confidence 0.45 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11955518 Disease Relevance 0 Pain Relevance 1.27
In contrast, chronic superfusion of tetrodotoxin onto the sciatic nerve resulted in a marked increase in mRNA levels and transcriptional activity of both DHP and RY receptor genes.
Positive_regulation (increase) of DHP in sciatic nerve associated with tetrodotoxin and sciatic nerve
3) Confidence 0.44 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7592768 Disease Relevance 0.09 Pain Relevance 0.25
Chronic s.c. infusion of sufentanil (2 micrograms/hr) for 7 days induced tolerance (tolerance index, 5.6) in association with up-regulation of DHP binding sites in cerebral cortex membranes (+36%), as well as in brain sections.
Positive_regulation (up-regulation) of DHP in brain associated with tolerance and cerebral cortex
4) Confidence 0.42 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562531 Disease Relevance 0.09 Pain Relevance 0.54
Under these conditions, a greater increase in the number of DHP binding sites was observed in cortex membranes (+71%), and more evidently in brain sections.
Positive_regulation (increase) of DHP in cortex
5) Confidence 0.37 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562531 Disease Relevance 0.07 Pain Relevance 0.66
Chronic s.c. infusion of sufentanil (2 microg/h) for 7 days, which has been shown to induce tolerance to the opioid antinociceptive effect, produced an up-regulation of DHP binding sites.
Positive_regulation (up-regulation) of DHP associated with tolerance, antinociceptive and opioid
6) Confidence 0.35 Published 2000 Journal Pain Section Abstract Doc Link 10812252 Disease Relevance 0.09 Pain Relevance 1.15
Under these conditions, a greater increase in the number of DHP binding sites was observed in the spinal cord, central grey matter, dorsal raphe nucleus, and somatosensory neocortex, when compared to the sufentanil group.
Positive_regulation (increase) of DHP in dorsal associated with raphe, central grey and spinal cord
7) Confidence 0.35 Published 2000 Journal Pain Section Abstract Doc Link 10812252 Disease Relevance 0.08 Pain Relevance 1.28
There was a significant up-regulation of DHP binding sites (B(max): +41%) in whole brain membranes of tolerant rats when compared to vehicle treated naive rats, implicating increased influx of Ca(2+) through L-type channels in kappa-opioid tolerance.
Positive_regulation (up-regulation) of DHP in brain associated with tolerance and opioid
8) Confidence 0.31 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11955518 Disease Relevance 0 Pain Relevance 1.52

General Comments

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