INT49466

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Context Info
Confidence 0.37
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cortex 2
Pah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 3 100.00 Very High Very High Very High
Somatosensory cortex 1 99.68 Very High Very High Very High
Spinal cord 1 95.92 Very High Very High Very High
antagonist 1 93.44 High High
opioid receptor 2 91.84 High High
agonist 1 90.68 High High
tolerance 4 87.32 High High
Opioid 3 86.92 High High
mu opioid receptor 4 84.40 Quite High
MU agonist 1 79.00 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 60 93.92 High High
Cv General 4 Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, oxoglutarate analogue suppresses PAH activity and increases endogenous HIF-1?
Negative_regulation (suppresses) of PAH Binding (activity) of
1) Confidence 0.37 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.34 Pain Relevance 0.11
Autoradiographic studies showed an overall decrease of[3H]-Ala2,MePhe4,Gly-(ol)5(2)]-enkephalin binding in the somatosensory cortex (around -30%).
Negative_regulation (decrease) of MePhe4 Binding (binding) of in cortex associated with somatosensory cortex and enkephalin
2) Confidence 0.01 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562532 Disease Relevance 0 Pain Relevance 1.13

General Comments

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