INT49472

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Context Info
Confidence 0.36
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.07
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MSR1) plasma membrane (MSR1)
Anatomy Link Frequency
brain 1
ovary 1
MSR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 99.96 Very High Very High Very High
Cannabinoid 5 99.74 Very High Very High Very High
Cannabinoid receptor 1 99.60 Very High Very High Very High
agonist 4 94.60 High High
cannabis 2 70.16 Quite High
Pain 1 52.16 Quite High
Analgesic 2 25.00 Low Low
cytokine 3 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Poisoning 2 69.44 Quite High
Pulmonary Alveolar Proteinosis 35 5.00 Very Low Very Low Very Low
Respiratory Failure 5 5.00 Very Low Very Low Very Low
Pneumothorax 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Renal Disease 2 5.00 Very Low Very Low Very Low
Anaemia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular we studied CD204 (Scavenger Receptor A, SR-A), a protein involved in cholesterol uptake [26]; PPAR?
CD204 Binding (uptake) of
1) Confidence 0.36 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
The effects of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4- benzoxazin-yl]-(1-napthalenyl)methanone mesylate (WIN 55,212-2) and N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazo le-carboxamide (SR141716A) on guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding to membranes isolated from human cannabinoid CB1 receptor-transfected Chinese hamster ovary (CHO) cells were examined.
SR141716A Spec (examined) Binding (binding) of in ovary associated with cannabinoid
2) Confidence 0.22 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9346339 Disease Relevance 0 Pain Relevance 0.20
A newly developed cannabinoid antagonist, SR141716A [N-(piperidin-1-yl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxa mide hydrochloride], binds to brain cannabinoid receptors and has been shown to block characteristic pharmacological effects of the aminoalkylindole cannabinoid agonist, WIN 55,212-2 (R-(+)-(2,3-dihydro-5-methyl-3-[(4-morpho- linyl)methyl]pyrol-(1,2,3-de]-1,4-benzoxazin-6-yl)(1-n aphthalenyl)methanone monomethanesulfonate).
SR141716A Binding (binds) of in brain associated with cannabinoid receptor, antagonist, cannabinoid and agonist
3) Confidence 0.02 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562536 Disease Relevance 0.07 Pain Relevance 0.28
Perhaps that now, new types of anthropotechnologies may allow us to push our physical and mental boundaries even further?


types Binding (boundaries) of
4) Confidence 0.02 Published 2009 Journal Med Stud Section Body Doc Link PMC2837237 Disease Relevance 0 Pain Relevance 0.05

General Comments

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