INT49473

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.28
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MSR1) plasma membrane (MSR1)
Anatomy Link Frequency
macrophages 4
plaques 1
adipose tissue 1
MSR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 100.00 Very High Very High Very High
glial activation 2 99.66 Very High Very High Very High
Spinal nerve ligature 1 98.44 Very High Very High Very High
Brush evoked pain 4 97.76 Very High Very High Very High
Neuropathic pain 7 95.88 Very High Very High Very High
withdrawal 1 95.48 Very High Very High Very High
tail-flick 5 95.00 High High
Acute pain 1 94.52 High High
Inflammation 15 93.68 High High
Spinal cord 1 93.56 High High
Disease Link Frequency Relevance Heat
Cancer 1 99.84 Very High Very High Very High
Necrosis 1 99.60 Very High Very High Very High
Atherosclerosis 234 99.48 Very High Very High Very High
Atherosclerotic Plaque 150 99.20 Very High Very High Very High
Obesity 80 98.76 Very High Very High Very High
Disease 91 98.32 Very High Very High Very High
Overweight 79 98.04 Very High Very High Very High
Neuropathic Pain 11 97.76 Very High Very High Very High
Pain 6 94.52 High High
Adhesions 6 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the LIGHT-mediated enhancement of SR-A and TF expression appears to involve nuclear factor-kappaB activation.
Gene_expression (expression) of SR-A
1) Confidence 0.75 Published 2005 Journal Circulation Section Body Doc Link 16186421 Disease Relevance 0 Pain Relevance 0
Within these groups of genes, gene expression of specific macrophage markers [e.g., CD14, CD163 and macrophage scavenger receptor 1 (MSR1)] was significantly higher in adipose tissue of overweight subjects (P < 0.001 for BMI-effect in two-way ANOVA), pointing towards presence of macrophages or inflammatory cells in the adipose tissue biopsies from overweight subjects.
Gene_expression (expression) of MSR1 in adipose tissue associated with inflammation, obesity and overweight
2) Confidence 0.36 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 1.59 Pain Relevance 0.05
Therefore, scavenger receptor expression is thought to be a critical determinant of lipid accumulation in macrophages.
Gene_expression (expression) of scavenger receptor in macrophages
3) Confidence 0.15 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.82 Pain Relevance 0
In addition, we identified SR-BIII as a novel SR-BI isoform expressed in human macrophages and in human atherosclerotic plaques.


Gene_expression (expressed) of SR-BIII in macrophages associated with atherosclerotic plaque
4) Confidence 0.15 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.64 Pain Relevance 0
We have previously identified a PTS1 motif in the C-terminus of SR-BI [8,24], which is not present in SR-BII and SR-BIII.
Neg (not) Gene_expression (present) of SR-BIII
5) Confidence 0.13 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.66 Pain Relevance 0.04
In addition, we identified SR-BIII as a novel isoform expressed in human macrophages and in human atherosclerotic plaques.



Gene_expression (expressed) of SR-BIII in plaques associated with atherosclerotic plaque
6) Confidence 0.11 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1215476 Disease Relevance 0.62 Pain Relevance 0
We have identified a novel isoform of SR-BI, SR-BIII, which is expressed in macrophages and atherosclerotic plaques.
Gene_expression (expressed) of SR-BIII in macrophages associated with atherosclerotic plaque
7) Confidence 0.11 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.56 Pain Relevance 0.03
A peroxisomal targeting sequence (PTS1) is present in the C-terminal domain of SR-BI, which is not present in the SR-BII and SR-BIII isoforms [8,24].
Neg (not) Gene_expression (present) of SR-BIII
8) Confidence 0.11 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.15 Pain Relevance 0
Those who preferred SR-CL were older (68.6 versus 65.7 years) and had longer disease duration (11.7 versus 10.0 years).39 The conclusion of this trial was that CLE was preferred by most patients to SR-CL.
Gene_expression (preferred) of SR-CL associated with disease
9) Confidence 0.09 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915499 Disease Relevance 0.73 Pain Relevance 0
Results of tests with various doses of SR141716A in combination with 3 mg/kg of delta 9-THC showed that SR141716A produced reversible, dose-dependent antagonism of the discriminative stimulus properties of delta 9-THC in rats, with recovery within 24 hr.
Gene_expression (produced) of SR141716A
10) Confidence 0.05 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562536 Disease Relevance 0.08 Pain Relevance 0.22
Thus, literacy not only involved the introduction of new tools for self-enhancement (the acquisition of new communicative skills), but also a replacement and re-contextualisation of the process of “producing” and shaping human beings, from homes and hamlets to novel types of buildings, directed towards discipline and control.
Gene_expression (producing) of types
11) Confidence 0.04 Published 2009 Journal Med Stud Section Body Doc Link PMC2837237 Disease Relevance 0 Pain Relevance 0
Glial activation markers such as macrophage antigen complex-1 (Mac-1, OX-42) and glial fibrillary acidic protein (GFAP), production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-10, as well as nuclear factor-kappa B (NF-kappaB) activation were determined in the lumbar spinal cord.
Gene_expression (production) of macrophage antigen complex-1 in macrophage associated with necrosis, cancer, spinal cord and glial activation
12) Confidence 0.02 Published 2009 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 19201747 Disease Relevance 0.85 Pain Relevance 0.76
Additionally, its multilevel and multi-interpretable nature and its use of condensed symbols allow the individual to express and communicate suffering caused by different types of stressors that cannot otherwise be expressed in the local social–cultural–political context, due to the inherent threat such expression would constitute to culturally dominant values and structures.
Neg (cannot) Gene_expression (expressed) of types
13) Confidence 0.01 Published 2010 Journal Cult Med Psychiatry Section Body Doc Link PMC2878590 Disease Relevance 0 Pain Relevance 0
Responses were also assessed in the presence of the CB-1 antagonist SR141716A (SR1) and the CB-2 antagonist SR144528 (SR2).
Gene_expression (presence) of SR144528 associated with antagonist
14) Confidence 0.00 Published 2004 Journal Pain Section Abstract Doc Link 15082134 Disease Relevance 0.58 Pain Relevance 1.54

General Comments

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