INT49477

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2008
Negated 1
Speculated 2
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 3.26
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr2c) nucleus (Htr2c) cytoplasm (Htr2c)
signal transducer activity (Htr2c)
Anatomy Link Frequency
renal artery 2
spike 1
nucleus 1
eye 1
seminal vesicles 1
Htr2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 50 100.00 Very High Very High Very High
agonist 21 99.96 Very High Very High Very High
5HT 6 99.84 Very High Very High Very High
Electroencephalography 1 99.24 Very High Very High Very High
fluoxetine 12 99.12 Very High Very High Very High
antidepressant 3 97.00 Very High Very High Very High
sSRI 9 96.92 Very High Very High Very High
antagonist 14 96.64 Very High Very High Very High
Pain 8 96.04 Very High Very High Very High
Dynorphin 5 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 213 98.40 Very High Very High Very High
Absence Epilepsy 2 96.12 Very High Very High Very High
Pain 8 96.04 Very High Very High Very High
Injury 4 94.32 High High
Stress 6 93.20 High High
Urological Neuroanatomy 3 91.84 High High
INFLAMMATION 8 86.72 High High
Nervous System Injury 1 82.04 Quite High
Neuropathic Pain 1 75.00 Quite High
Obsessive-compulsive Disorder 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of protein expression analyses allow us to postulate that 5HT-SRC (a 5-HT2C receptor protein) is expressed in renal tissue and differentially expressed in renal artery.
Gene_expression (expressed) of 5-HT2C in renal artery associated with 5ht
1) Confidence 0.75 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18644367 Disease Relevance 0 Pain Relevance 0.37
The results of protein expression analyses allow us to postulate that 5HT-SRC (a 5-HT2C receptor protein) is expressed in renal tissue and differentially expressed in renal artery.
Gene_expression (expressed) of 5-HT2C in renal artery associated with 5ht
2) Confidence 0.75 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18644367 Disease Relevance 0 Pain Relevance 0.37
Specifically, we detected increase in the expression of 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C and 5-HT4 receptors.
Gene_expression (expression) of 5-HT2C
3) Confidence 0.75 Published 2005 Journal Neuroscience Section Abstract Doc Link 15730869 Disease Relevance 1.29 Pain Relevance 0.49
Reverse transcriptase-polymerase chain reaction (RT-PCR) revealed expression of 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5B, 5-HT6 and 5-HT7 receptor mRNAs in astrocytes derived from 2-day old rats and cultured for 10-12 days.
Gene_expression (expression) of 5-HT2C in astrocytes
4) Confidence 0.75 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9795156 Disease Relevance 0 Pain Relevance 0.14
We analyzed the expression of three types of serotonin receptors: 5-HT1B, 5-HT2C and 5-HT1D by reverse transcription-polymerase chain reaction in mouse unfertilized oocytes and preimplantation embryos from zygotes to the blastocyst stage in vivo.
Spec (analyzed) Gene_expression (expression) of 5-HT2C in zygotes associated with serotonin
5) Confidence 0.75 Published 2003 Journal Physiol Res Section Abstract Doc Link 12678665 Disease Relevance 0 Pain Relevance 0.38
Expression of the mRNAs of the 5-hydroxytryptamine (5-HT) receptors (5-HT1A, 5-HT1B, and 5-HT2C), which have been suggested to be involved in the ejaculation process, were examined by semiquantitative reverse-transcriptase polymerase chain reaction (RT-PCR).
Spec (examined) Gene_expression (Expression) of 5-HT2C
6) Confidence 0.75 Published 2004 Journal J. Androl. Section Abstract Doc Link 15477361 Disease Relevance 0 Pain Relevance 0.47
The activation of postsynaptic 5-HT2A and 5-HT2C receptors may be important in the improvement of OCD symptoms after treatment with an SSRI.45 Studies in OCD patients showed blunted prolactin and cortisol responses to 5-HT2 receptor agonists.46 Enoch et al.47 recruited and genotyped 101 Caucasian OCD patients (48 females, 53 males) and 138 control subjects (77 females, 61 males) and found that the -1438A allele frequency was higher only in female OCD patients and not in male patients.
Gene_expression (receptors) of 5-HT2C associated with anxiety disorder, agonist and ssri
7) Confidence 0.65 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.87 Pain Relevance 0.19
However, the expression levels of 5-HT1B and 5-HT2C receptor mRNAs were lower in the vasa deferentia than in the seminal vesicles.
Gene_expression (expression) of 5-HT2C in seminal vesicles
8) Confidence 0.65 Published 2004 Journal J. Androl. Section Abstract Doc Link 15477361 Disease Relevance 0 Pain Relevance 0.46
5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy.
Gene_expression (inhibit) of 5-HT2C in spike associated with absence epilepsy
9) Confidence 0.65 Published 2003 Journal Exp. Neurol. Section Title Doc Link 14769389 Disease Relevance 0.19 Pain Relevance 0.41
The electroencephalography defined sleep-waking pattern in rats produced by these two 5-HT2C agonists, as well as fluoxetine, included increased quiet-waking and decreased rapid-eye-movement sleep, which is characteristic of antidepressant drugs.
Gene_expression (produced) of 5-HT2C in eye associated with antidepressant, agonist, electroencephalography and fluoxetine
10) Confidence 0.65 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694950 Disease Relevance 0 Pain Relevance 0.57
Within lumbar dorsal root ganglia, the presence of the 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3 and 5-HT7 receptor subtype messenger RNAs was detected.
Gene_expression (presence) of 5-HT2C in dorsal root ganglia
11) Confidence 0.65 Published 1996 Journal Neuroscience Section Abstract Doc Link 8848158 Disease Relevance 0.07 Pain Relevance 0.18
Within these islands, 5-HT2C mRNA expression was much higher than in surrounding areas. 5-HT2A mRNA showed the opposite pattern with decreased expression over dynorphin rich cell clusters.
Gene_expression (expression) of 5-HT2C associated with dynorphin
12) Confidence 0.65 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8799865 Disease Relevance 0 Pain Relevance 0.70
Polymerase chain reaction amplification of 5-HT receptor cDNA demonstrates that 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A and 5-HT3, but not the 5-HT2C, receptor subtypes are present in lumbar sympathetic ganglia.
Neg (not) Gene_expression (present) of 5-HT2C in sympathetic
13) Confidence 0.58 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562592 Disease Relevance 0.28 Pain Relevance 0.47
We evaluated changes in mRNA editing and 5HT2C mRNA expression using cloning along with sequence analysis and quantitative reverse transcription-polymerase chain reaction to compare samples taken at post-injury day 28 from spinal cord sites, including the trigeminal nucleus caudalis, in naive, sham and injured rats (groups of each type had also received fluvoxamine). 5HT2C receptor expression was maintained post-injury.
Gene_expression (expression) of 5HT2C mRNA in nucleus associated with injury and spinal cord
14) Confidence 0.50 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18445227 Disease Relevance 0.57 Pain Relevance 0.55

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