INT49483

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 8
Total Number 12
Disease Relevance 2.34
Pain Relevance 9.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
RVM 2
brain 2
striatum 2
CeA 2
spinal 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 27 100.00 Very High Very High Very High
opioid receptor 26 100.00 Very High Very High Very High
Rostral ventromedial medulla 21 100.00 Very High Very High Very High
mu opioid receptor 20 100.00 Very High Very High Very High
Central grey 15 100.00 Very High Very High Very High
tolerance 6 100.00 Very High Very High Very High
projection neuron 4 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 2 100.00 Very High Very High Very High
Neuropeptide 1 99.98 Very High Very High Very High
narcan 3 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 15 100.00 Very High Very High Very High
Hyperglycemia 2 99.92 Very High Very High Very High
Stress 4 99.84 Very High Very High Very High
Insulin Resistance 1 99.76 Very High Very High Very High
Diabetes Mellitus 10 99.68 Very High Very High Very High
Nociception 1 94.72 High High
Contracture 1 91.16 High High
Opiate Addiction 1 84.48 Quite High
Targeted Disruption 1 71.32 Quite High
Toxicity 1 49.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that hyperglycemia is responsible for increase of opioid mu-receptor in STZ-diabetic rats.
Regulation (responsible) of Positive_regulation (increase) of mu-receptor associated with hyperglycemia, diabetes mellitus and opioid
1) Confidence 0.61 Published 2001 Journal Horm. Metab. Res. Section Abstract Doc Link 11544560 Disease Relevance 0.83 Pain Relevance 0.67
In the present study, we investigated the effect of repeated administration of 7-nitroindazole (7-NI; 30 mg/kg/12 h, i.p., 3 days), an inhibitor of neuronal nitric oxide synthase in vivo, on mu-opioid receptor tolerance induced by subchronic treatment with morphine in rats.
Spec (investigated) Regulation (effect) of Positive_regulation (induced) of mu-opioid receptor in neuronal associated with tolerance, opioid receptor, morphine and neuronal nitric oxide synthase
2) Confidence 0.40 Published 2005 Journal Synapse Section Abstract Doc Link 15858834 Disease Relevance 0 Pain Relevance 1.38
In this study, we compared the effects of five short-, medium-, or long-acting benzodiazepine-receptor agonists (BZDs) [alprazolam (APZ), clonazepam (CLZ), flunitrazepam (FLZ), loprazolam (LPZ), zolpidem (ZLP)], at two distinct doses, 0.2 and 2 mg/kg, on the cell surface regulation of mu-opioid receptor induced by 0.15 mg/kg buprenorphine (BPN) in specific regions of the rat brain.
Regulation (regulation) of Positive_regulation (induced) of mu-opioid receptor in brain associated with agonist, opioid receptor and buprenorphine
3) Confidence 0.27 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19443999 Disease Relevance 0 Pain Relevance 0.87
In this study, we examined the effect of mu opioid receptor stimulation on the inhibitory and excitatory synaptic inputs to CeA-projecting BLA neurons.
Spec (examined) Regulation (effect) of Spec (examined) Positive_regulation (stimulation) of mu opioid receptor in CeA associated with mu opioid receptor and amygdala
4) Confidence 0.26 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16306173 Disease Relevance 0 Pain Relevance 1.15
Neuropeptides regulate striatal cholinergic transmission and particularly activation of mu opioid receptor (MOR) inhibits acetylcholine (ACh) release in the dorsal striatum.
Regulation (regulate) of Positive_regulation (activation) of mu opioid receptor in striatum associated with mu opioid receptor and neuropeptide
5) Confidence 0.24 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16026468 Disease Relevance 0 Pain Relevance 0.46
In addition, direct effects on PAG-RVM projection neurons from activation of MOR1 appear more likely to be exerted in the ventrolateral PAG than in the dorsomedial PAG.
Regulation (effects) of Positive_regulation (activation) of MOR1 in RVM associated with opioid receptor, projection neuron, central grey and rostral ventromedial medulla
6) Confidence 0.20 Published 2002 Journal Neuroscience Section Abstract Doc Link 11823071 Disease Relevance 0.77 Pain Relevance 1.22
In this study, we determined the effect of mu-opioid receptor activation on excitatory and inhibitory synaptic transmission in spinally projecting RVM neurons.
Spec (determined) Regulation (effect) of Spec (determined) Positive_regulation (activation) of mu-opioid receptor in neurons associated with opioid receptor and rostral ventromedial medulla
7) Confidence 0.15 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14724227 Disease Relevance 0.09 Pain Relevance 0.88
[Morphofunctional manifestations of cardioprotective effect of mu-opioid receptor stimulation in stress].
Regulation (effect) of Positive_regulation (stimulation) of mu-opioid receptor associated with stress and opioid receptor
8) Confidence 0.07 Published 2001 Journal Patol Fiziol Eksp Ter Section Title Doc Link 11550368 Disease Relevance 0.46 Pain Relevance 0.18
This study demonstrates that activation of the mu receptor subtype is responsible for the opioid-induced release of adenosine from the spinal cord, that such release contributes to the spinal antinociception by mu agonists and that only release evoked by low doses of opioids is behaviorally relevant.
Regulation (responsible) of Positive_regulation (activation) of mu receptor in spinal associated with antinociception, mu agonist, adenocard, opioid and spinal cord
9) Confidence 0.02 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562600 Disease Relevance 0 Pain Relevance 1.76
Acute and chronic activation of the mu-opioid receptor with the endogenous ligand endomorphin differentially regulates adenylyl cyclase isozymes.
Regulation (regulates) of Positive_regulation (activation) of mu-opioid receptor associated with narcan and opioid receptor
10) Confidence 0.02 Published 2000 Journal Neuropharmacology Section Title Doc Link 10698002 Disease Relevance 0.08 Pain Relevance 0.39
AIMS/HYPOTHESIS: This study investigated the role of opioid mu-receptor activation in the improvement of insulin resistance.
Spec (investigated) Regulation (role) of Spec (investigated) Positive_regulation (activation) of opioid mu-receptor associated with insulin resistance and opioid
11) Confidence 0.01 Published 2005 Journal Diabetologia Section Abstract Doc Link 15959754 Disease Relevance 0.10 Pain Relevance 0.17
Mechanisms involved in phosphatidylinositol 3-kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes.
Regulation (involved) of Positive_regulation (up-regulation) of mu opioid receptor in lymphocytes associated with mu opioid receptor
12) Confidence 0.01 Published 2010 Journal Biochem. Pharmacol. Section Title Doc Link 19765550 Disease Relevance 0 Pain Relevance 0.27

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