INT49486

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Context Info
Confidence 0.52
First Reported 1995
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 4.17
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cma1) extracellular region (Cma1) intracellular (Cma1)
Anatomy Link Frequency
Mast cells 3
Cma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 10 98.08 Very High Very High Very High
cytokine 4 97.84 Very High Very High Very High
interstitial cystitis 5 94.32 High High
spastic colon 1 94.04 High High
pulpitis 2 84.40 Quite High
Potency 1 55.36 Quite High
fibrosis 4 25.00 Low Low
Inflammatory response 2 25.00 Low Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 150 98.60 Very High Very High Very High
Leukemia 7 98.56 Very High Very High Very High
INFLAMMATION 12 98.08 Very High Very High Very High
Cancer 2 97.12 Very High Very High Very High
Necrosis 2 96.56 Very High Very High Very High
Interstitial Cystitis 5 94.32 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 94.24 High High
Functional Bowel Disorder 1 94.04 High High
Food Hypersensitivity 1 92.88 High High
Lichen 4 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chymase leading to tissue remodeling is expected to be a potent pharmaceutical target.
Gene_expression (expected) of Chymase
1) Confidence 0.52 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12499575 Disease Relevance 0.15 Pain Relevance 0.03
The flavonoid quercetin is one of very few molecules that inhibit RBL cell proliferation and constitutive histamine release; it also induces synthesis of rat mast cell protease (RMCP) II and accumulation of secretory granules.
Gene_expression (synthesis) of mast cell protease in mast cell associated with leukemia
2) Confidence 0.48 Published 1999 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 10405873 Disease Relevance 0.75 Pain Relevance 0.09
In addition, the higher contribution of chymase in Ang-(1–12) metabolism found in SHR compared to WKY controls is in keeping with previous findings of increased chymase activity in SHR. [32]
Gene_expression (contribution) of chymase associated with hypertension
3) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.33 Pain Relevance 0
This finding is in keeping with reports showing augmented chymase expression and increased chymostatin-inhibitable angiotensin-converting activity in SHR. [10] The increased hydrolytic effects of chymase on 125I-Ang-(1–12) metabolism in SHR was associated with a greater processing activity of ACE and NEP.
Gene_expression (expression) of chymase associated with hypertension
4) Confidence 0.28 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.68 Pain Relevance 0
Mast cells in oral tissues expressed the serine proteases, tryptase and chymase, with a minor subpopulation being chymase-negative.
Gene_expression (expressed) of chymase in Mast cells
5) Confidence 0.08 Published 1995 Journal J. Oral Pathol. Med. Section Abstract Doc Link 7562663 Disease Relevance 0.90 Pain Relevance 0.33
Mast cells in oral tissues expressed the serine proteases, tryptase and chymase, with a minor subpopulation being chymase-negative.
Gene_expression (negative) of chymase-negative in Mast cells
6) Confidence 0.06 Published 1995 Journal J. Oral Pathol. Med. Section Abstract Doc Link 7562663 Disease Relevance 0.93 Pain Relevance 0.34
It has been suggested that the proteinase content defines two MC types: MC(TC), containing chymase and tryptase, and MC(T), which contains tryptase but lacks chymase.
Neg (lacks) Gene_expression (lacks) of chymase
7) Confidence 0.05 Published 2000 Journal J. Urol. Section Abstract Doc Link 10688040 Disease Relevance 0.34 Pain Relevance 0.34

General Comments

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