INT49487

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Context Info
Confidence 0.76
First Reported 1993
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 65
Total Number 72
Disease Relevance 68.11
Pain Relevance 19.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sele) cell adhesion (Sele) molecular_function (Sele)
cellular_component (Sele)
Anatomy Link Frequency
lung 10
plasma 8
neutrophils 3
epithelium 3
endothelial cells 3
Sele (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 123 100.00 Very High Very High Very High
Inflammatory mediators 95 99.82 Very High Very High Very High
cva 331 99.58 Very High Very High Very High
Infliximab 128 99.44 Very High Very High Very High
rheumatoid arthritis 366 98.92 Very High Very High Very High
Inflammation 793 98.68 Very High Very High Very High
Arthritis 167 97.32 Very High Very High Very High
metalloproteinase 2 97.16 Very High Very High Very High
Inflammatory marker 29 96.92 Very High Very High Very High
cytokine 246 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 379 100.00 Very High Very High Very High
Cv General 3 Under Development 111 100.00 Very High Very High Very High
Hypersensitivity 774 99.84 Very High Very High Very High
Acute Coronary Syndrome 76 99.84 Very High Very High Very High
Atherosclerotic Plaque 11 99.74 Very High Very High Very High
INFLAMMATION 717 99.62 Very High Very High Very High
Myocardial Infarction 48 99.60 Very High Very High Very High
Subarachnoid Hemorrhage 280 99.58 Very High Very High Very High
Psoriasis 164 99.48 Very High Very High Very High
Fat Embolism 35 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AECA positive sera were further evaluated for its ability to promote in vitro E-selectin expression by HUVEC using a cell-based ELISA.
Gene_expression (expression) of E-selectin
1) Confidence 0.76 Published 2000 Journal Immunol. Lett. Section Abstract Doc Link 10963807 Disease Relevance 0.87 Pain Relevance 0.13
Furthermore, AECA positive sera from patients, with or without coronary atherosclerosis displayed similar capacity of inducing E-selectin expression by endothelial cells.
Gene_expression (expression) of E-selectin in endothelial cells associated with atherosclerosis
2) Confidence 0.76 Published 2000 Journal Immunol. Lett. Section Abstract Doc Link 10963807 Disease Relevance 0.90 Pain Relevance 0.11
E-selectin is a CAM that is only expressed on activated endothelial cells.
Gene_expression (expressed) of E-selectin in endothelial cells
3) Confidence 0.73 Published 1997 Journal Circulation Section Abstract Doc Link 9133511 Disease Relevance 0.41 Pain Relevance 0.07
Semiquantitative PCR revealed that E-selectin and IL-6 gene expressions were increased in rats following LPS injection, and an overdose of tamoxifen, an estrogen receptor antagonist, reversed the effect of 17beta-estradiol on E-selectin, but not its effect on IL-6.
Gene_expression (expressions) of E-selectin associated with antagonist and overdose
4) Confidence 0.68 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384138 Disease Relevance 0.90 Pain Relevance 0.19
Estrogen protects against cellular infiltration by reducing the expressions of E-selectin and IL-6 in endotoxin-induced uveitis.
Gene_expression (expressions) of E-selectin associated with uveitis
5) Confidence 0.68 Published 1999 Journal J. Immunol. Section Title Doc Link 10384138 Disease Relevance 1.00 Pain Relevance 0.16
Anti-P-selectin and anti-E-selectin produced only small (approximately 35%), but statistically significant, reductions of mucosal injury, but only anti-P-selectin significantly affected indomethacin-induced leukocyte adherence (by approximately 50%).
Gene_expression (produced) of anti-E-selectin in leukocyte associated with injury
6) Confidence 0.60 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7694504 Disease Relevance 0.84 Pain Relevance 0.25
Lungs of OVx allergic rats significantly increased the E-selectin expression, an effect prevented by estradiol but not by progesterone treatment.
Gene_expression (expression) of E-selectin in Lungs associated with hypersensitivity
7) Confidence 0.51 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2936382 Disease Relevance 0.86 Pain Relevance 0.11
In addition, an increased E-selectin expression in lungs was also found.
Gene_expression (expression) of E-selectin in lungs
8) Confidence 0.51 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.22 Pain Relevance 0.12
Interestingly, estradiol prevents artery wall thickness by mechanism involving a diminished E-selectin expression in postmenopausal women [41].
Gene_expression (expression) of E-selectin in artery
9) Confidence 0.51 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.50 Pain Relevance 0.30
In renal tissue vagal stimulation significantly decreased the expression of E-selectin, IL1beta and ITGA6.
Gene_expression (expression) of E-selectin
10) Confidence 0.50 Published 2010 Journal Am. J. Transplant. Section Abstract Doc Link 20055812 Disease Relevance 0.99 Pain Relevance 0.38
Expression of E-selectin, sialyl Lewis X, and macrophage inflammatory protein-1alpha by colonic epithelial cells in ulcerative colitis.
Gene_expression (Expression) of E-selectin in epithelial cells associated with inflammatory bowel disease and inflammation
11) Confidence 0.41 Published 1998 Journal Dig. Dis. Sci. Section Title Doc Link 9539657 Disease Relevance 0.95 Pain Relevance 0.18
It is shown that E-selectin, sLe(x), and MIP-1alpha are synthesized and expressed by epithelial cells, indicating that CAMs are not only involved in leukocyte extravasation and migration, but also in the interaction between leukocytes and colonic epithelium.
Gene_expression (expressed) of E-selectin in epithelium
12) Confidence 0.41 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539657 Disease Relevance 0.80 Pain Relevance 0.15
Colonic expression of E-selectin, sialyl Lewis X (sLe(x)), and macrophage inflammatory protein-1x (MIP-1alpha) as well as serum concentrations of E-selectin and MIP-1alpha in UC were studied.
Gene_expression (expression) of E-selectin in macrophage associated with inflammatory bowel disease and inflammation
13) Confidence 0.41 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539657 Disease Relevance 0.87 Pain Relevance 0.17
It is shown that E-selectin, sLe(x), and MIP-1alpha are synthesized and expressed by epithelial cells, indicating that CAMs are not only involved in leukocyte extravasation and migration, but also in the interaction between leukocytes and colonic epithelium.
Gene_expression (synthesized) of E-selectin in epithelium
14) Confidence 0.41 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539657 Disease Relevance 0.80 Pain Relevance 0.15
Female sex hormones mediate the allergic lung reaction by regulating the release of inflammatory mediators and the expression of lung E-selectin in rats

Background

Gene_expression (expression) of E-selectin in lung associated with inflammatory mediators and hypersensitivity
15) Confidence 0.39 Published 2010 Journal Respir Res Section Title Doc Link PMC2936382 Disease Relevance 0.59 Pain Relevance 0.13
In contrast, progesterone treatment did not exert effects on the E-selectin expression of lung of OVX-allergic rats (Fig. 10A).
Gene_expression (expression) of E-selectin in lung associated with hypersensitivity
16) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.04 Pain Relevance 0
Regulatory role of sex hormones on the lung expression of E-selectin in allergic rats
Gene_expression (expression) of E-selectin in lung associated with hypersensitivity
17) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.04 Pain Relevance 0.03
Lungs of OVx-allergic rats upon estradiol treatment decreased the E-selectin expression to levels close to those found in lung of Sham-OVx allergic rats.
Gene_expression (expression) of E-selectin in lung associated with hypersensitivity
18) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.03 Pain Relevance 0
Indeed, E-selectin expression of lung was decreased in estradiol treated OVx allergic rats.
Gene_expression (expression) of E-selectin in lung associated with hypersensitivity
19) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.19 Pain Relevance 0.27
Immunohystochemistry for lung E-Selectin expression
Gene_expression (expression) of E-Selectin in lung
20) Confidence 0.34 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 0.08 Pain Relevance 0

General Comments

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