INT49488

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 37
Total Number 37
Disease Relevance 26.11
Pain Relevance 7.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cells 8
bladder 3
connective tissue 2
urine 2
blood 1
mMCP-7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 865 100.00 Very High Very High Very High
metalloproteinase 9 98.32 Very High Very High Very High
Pain 134 97.96 Very High Very High Very High
Inflammatory stimuli 73 95.44 Very High Very High Very High
Morphine 25 93.52 High High
cytokine 77 92.80 High High
antagonist 11 92.52 High High
agonist 25 88.96 High High
fibrosis 30 88.32 High High
cva 16 87.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1060 100.00 Very High Very High Very High
Hypersensitivity 25 100.00 Very High Very High Very High
Sclerosis 8 99.88 Very High Very High Very High
Death 279 99.68 Very High Very High Very High
Microphthalmia 207 99.12 Very High Very High Very High
Cystitis 126 98.80 Very High Very High Very High
Cutaneous Mastocytosis 120 98.56 Very High Very High Very High
Bladder Cancer 28 98.56 Very High Very High Very High
Parasitic Infection 1 98.44 Very High Very High Very High
Infection 29 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mast cell proteases mcpt-5 (chymase), and the tryptases mcpt-6 and mcpt-7 are all expressed during the development of the mouse embryo [63].
Gene_expression (expressed) of mcpt-7 in embryo
1) Confidence 0.75 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.27 Pain Relevance 0.17
We also examined the correlation between the OPA score and the total serum tryptase level because a level ?
Gene_expression (level) of tryptase
2) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 0.79 Pain Relevance 0
We also did not find a significant difference in the overall perception of disability (OPA and AFIRMM scores) or standard measures of disability according to the serum tryptase level (?
Gene_expression (level) of tryptase
3) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 0.45 Pain Relevance 0
Minor criteria for a diagnosis of SM can include abnormal mast cell morphologies in the bone marrow and other extracutaneous organs, mutation of the tyrosine kinase KIT at codon 816, expression of CD2 and/or CD25 by bone marrow mast cells, and a serum tryptase level >20 ng/mL.
Gene_expression (expression) of tryptase in bone marrow associated with systemic mastocytosis
4) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 2.15 Pain Relevance 0.06
Ocular discomfort was somewhat more common in patients with a serum tryptase level ?
Gene_expression (level) of tryptase
5) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 0.56 Pain Relevance 0.16
The detection limit of this assay is 1 ng/mL, and in healthy controls, serum tryptase levels range between <1 and 15 ng/mL, with a median of ?
Gene_expression (levels) of tryptase
6) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 0 Pain Relevance 0
Serine proteases such as thrombin, trypsin and mast cell tryptase can act on different cell types through protease-activated receptors (PARs).
Gene_expression (proteases) of tryptase in mast cell
7) Confidence 0.33 Published 2009 Journal Pain Section Abstract Doc Link 19674841 Disease Relevance 0.38 Pain Relevance 0.32
Similarly, other mast cell degranulation products such as tryptase and histamine are capable of modulating neuronal function [27-32].
Gene_expression (products) of tryptase in mast cell
8) Confidence 0.28 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC554992 Disease Relevance 0.93 Pain Relevance 0.64
Interestingly, the zymogen forms of the matrix metalloproteinases prostromelysin and procollagenase are activated by specific MC subsets that either express tryptase (MCT) or tryptase and chymase (MCTC) [48,49].
Gene_expression (express) of tryptase associated with metalloproteinase
9) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.58 Pain Relevance 0.28
Interestingly, the zymogen forms of the matrix metalloproteinases prostromelysin and procollagenase are activated by specific MC subsets that either express tryptase (MCT) or tryptase and chymase (MCTC) [48,49].
Gene_expression (express) of tryptase associated with metalloproteinase
10) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.57 Pain Relevance 0.28
Tryptase and cathepsin D levels were higher (25%) in patients with active peptic ulcer, whether gastric or duodenal.
Gene_expression (levels) of Tryptase associated with ulcers
11) Confidence 0.25 Published 1994 Journal Res Exp Med (Berl) Section Abstract Doc Link 8202635 Disease Relevance 1.68 Pain Relevance 0.08
All sections were blocked in PBS, 5% goat serum albumin (blocking buffer) for 20 min, and staining was performed with the following primary antibodies at the given dilution in blocking buffer (1 hour, room temperature): mouse monoclonal antibodies against CXCR1 (Clone 42705.111, 1:40; R&D Systems, Minneapolis, MN, USA), CXCR2 (Clone 48311.211, 1:10; R&D), CXCR3 (Clone 49801.111, 1:100; R&D), MC tryptase (Clone AA1, 1:50; Dako, Hamburg, Germany), CD68 (Clone KP1, 1:80; Dako), fibroblast prolyl-4-hydroxylase (Clone 5B5, 1:10; Dako), and CD3 (Clone F7.2.38, 1:50; Dako).
Gene_expression (antibodies) of tryptase in fibroblast
12) Confidence 0.22 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.11 Pain Relevance 0.06
Pretreatment for MC tryptase staining involved 5 min incubation with 0.1% pronase (Sigma, St.
Gene_expression (staining) of tryptase
13) Confidence 0.22 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.14 Pain Relevance 0.07
Chymase-expressing mast cells are generally classified as non-immune mast cells, differentiating them from mast cells that only express tryptase and that are involved in allergic and parasitic diseases [34].
Gene_expression (express) of tryptase in mast cells associated with parasitic infection and hypersensitivity
14) Confidence 0.22 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.02 Pain Relevance 0.04
In addition to tryptase, other serine proteases such as thrombin and trypsin are produced during tissue damage and make important contributions to tissue responses to injury, repair, cell survival, inflammation [9-12], and pain [13-17].
Gene_expression (produced) of tryptase associated with pain, inflammation and injury
15) Confidence 0.21 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 1.20 Pain Relevance 0.32
As a consequence of inflammation, products of mast cell degranulation, such as tryptase, can be found in the urine of cystitis patients [15].
Gene_expression (products) of tryptase in urine associated with inflammation and cystitis
16) Confidence 0.19 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 1.14 Pain Relevance 0.28
In addition to tryptase, other serine proteases such as thrombin and trypsin are produced during tissue damage and make important contributions to tissue responses to injury, repair, cell survival, inflammation [16-19], and pain [20-24].
Gene_expression (produced) of tryptase associated with pain, inflammation and injury
17) Confidence 0.19 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 1.14 Pain Relevance 0.30
However, to the best of our knowledge, there is no information regarding which particular tryptase is expressed in the mouse bladder and/or upregulated in this mouse model during inflammation.
Gene_expression (expressed) of tryptase in bladder associated with inflammation
18) Confidence 0.17 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.28 Pain Relevance 0.20
Mouse mast cell protease-7 is a tryptase predominantly expressed in differentiated connective tissue-type mast cells [52].
Gene_expression (expressed) of tryptase in mast cells
19) Confidence 0.17 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.46 Pain Relevance 0.18
There was a significant correlation between the number of infiltrated MCs in the lung sections of the HLT group and the femoral blood tryptase concentration (p < 0.05).


Gene_expression (concentration) of tryptase in blood
20) Confidence 0.11 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350147 Disease Relevance 0.38 Pain Relevance 0.25

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