INT49490

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 14.76
Pain Relevance 7.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
sacroiliac joints 4
brain 2
nucleus 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 243 100.00 Very High Very High Very High
chemokine 28 100.00 Very High Very High Very High
cINOD 68 99.50 Very High Very High Very High
Crohn's disease 65 99.48 Very High Very High Very High
rheumatoid arthritis 12 99.20 Very High Very High Very High
Inflammatory mediators 6 98.80 Very High Very High Very High
spinal inflammation 102 98.32 Very High Very High Very High
Paracetamol 1 98.32 Very High Very High Very High
aspirin 50 97.48 Very High Very High Very High
antagonist 8 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 56 100.00 Very High Very High Very High
Cancer 25 100.00 Very High Very High Very High
Necrosis 19 100.00 Very High Very High Very High
Disease 203 99.48 Very High Very High Very High
Coronary Heart Disease 7 99.34 Very High Very High Very High
Rheumatoid Arthritis 12 99.20 Very High Very High Very High
Lichen 2 99.02 Very High Very High Very High
Acid Reflux 36 98.90 Very High Very High Very High
INFLAMMATION 318 98.80 Very High Very High Very High
Injury 18 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin or lysine-acetylsalicylic acid concentration-dependently inhibited prostaglandin E(2) biosynthesis and, at concentrations causing near-complete inhibition, enhanced TNFalpha mRNA and protein expression without significantly influencing cyclooxygenase-2 mRNA.
Positive_regulation (enhanced) of Transcription (expression) of TNFalpha associated with aspirin
1) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.15 Pain Relevance 0.28
When IL-6 binds to its receptor, a mechanism is triggered blocking Janus Kinase signal and activator of transcription (JAK/STAT) mediated transcription of IL-1 and TNF-?
Positive_regulation (mediated) of Transcription (transcription) of TNF
2) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2891797 Disease Relevance 0.57 Pain Relevance 0.35
We previously reported that in a rat model of mixed reflux esophagitis, intraduodenal rebamipide significantly inhibited the increased expression of mRNA and protein for CINC-1 and TNF-?
Positive_regulation (protein) of Transcription (expression) of TNF associated with acid reflux
3) Confidence 0.49 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.87 Pain Relevance 0.44
gene, then translocates from the cytoplasm to the nucleus where it activates transcription of target genes such as TNF?
Positive_regulation (activates) of Transcription (transcription) of TNF in nucleus
4) Confidence 0.49 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0 Pain Relevance 0.13
We previously reported that in a rat model of mixed reflux esophagitis, intraduodenal rebamipide significantly inhibited the increased expression of mRNA and protein for CINC-1 and TNF-?
Positive_regulation (increased) of Transcription (expression) of TNF associated with acid reflux
5) Confidence 0.49 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.87 Pain Relevance 0.44
Indeed, results showed that ex-vivo cultures of inflamed colonic biopsies re-stimulated with these peptides were able to consistently induce a proinflammatory cytokine profile dominated by increased mRNA levels of TNF?
Positive_regulation (increased) of Transcription (levels) of TNF associated with cytokine
6) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.70 Pain Relevance 0.30
mRNA and TNF protein in the sacroiliac joints demonstrated that TNF-?
Positive_regulation (demonstrated) of Transcription (protein) of TNF in sacroiliac joints
7) Confidence 0.39 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580004 Disease Relevance 1.51 Pain Relevance 1.23
In lichen planus, intracellular stores of TNF were depleted, and expression of mRNA for TNF was upregulated, indicating ongoing production and release of the cytokine.
Positive_regulation (upregulated) of Transcription (expression) of TNF associated with lichen and cytokine
8) Confidence 0.38 Published 1995 Journal J. Oral Pathol. Med. Section Abstract Doc Link 7562663 Disease Relevance 1.00 Pain Relevance 0.40
Increased ROS levels in the cytosol can also lead to increased gene transcription of an array of genes involved in oxidative stress and immunity, including TNF-?
Positive_regulation (increased) of Transcription (transcription) of TNF associated with stress
9) Confidence 0.29 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 1.39 Pain Relevance 0.04
Given that TNF mRNA concentrations are elevated in the sacroiliac joint in patients with AS, it seemed logical to test the hypothesis that TNF antagonists could improve outcomes in patients with AS.
Positive_regulation (elevated) of Transcription (concentrations) of TNF in sacroiliac joint associated with spinal inflammation and antagonist
10) Confidence 0.29 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC2833456 Disease Relevance 1.58 Pain Relevance 1.31
1 significantly induced the transcription of TNF and IL-1?
Positive_regulation (induced) of Transcription (transcription) of TNF
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.28 Pain Relevance 0.33
secretion which is induced by transcriptional upregulation of TNF-?
Positive_regulation (upregulation) of Transcription (transcriptional) of TNF
12) Confidence 0.21 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.68 Pain Relevance 0
Increased ROS levels in the cytosol can also lead to increased gene transcription of an array of genes involved in oxidative stress and immunity, including TNF-?
Positive_regulation (lead) of Transcription (transcription) of TNF associated with stress
13) Confidence 0.21 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 1.40 Pain Relevance 0.04
Although several studies have shown that MI/R increases myocardial TNF concentrations, which contributes to irreversible tissue injury and myocardial dysfunction [2], Chong et al. reported that TNF mRNA expression was not increased after MI/R in wild type and C3H/HeJ mice compared to sham-operated mice, whereas myocardial mRNA expression of IL-1?
Neg (not) Positive_regulation (increased) of Transcription (expression) of TNF associated with injury and coronary heart disease
14) Confidence 0.09 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1933437 Disease Relevance 0.56 Pain Relevance 0.24
In the same line of research, there are reports that demonstrate the enhanced expression of TNF mRNA in the brain of T. brucei-infected mice [263, 264] and the correlation in trypanosome-infected cattle between TNF production by monocytes and the severity of diseases-associated anemia [265].
Positive_regulation (enhanced) of Transcription (expression) of TNF in brain associated with anaemia and disease
15) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.61 Pain Relevance 0.04
NSAID treatment significantly increased mRNA and protein levels of TNF-?
Positive_regulation (increased) of Transcription (levels) of TNF associated with cinod
16) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 1.10 Pain Relevance 1.20
A comparative study using quantitative PCR and cDNA arrays demonstrated that H5N1/97 viruses induced much higher gene transcription of proinflammatory cytokines, particularly TNF-?
Positive_regulation (induced) of Transcription (transcription) of TNF associated with cytokine
17) Confidence 0.04 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.86 Pain Relevance 0.24
At the acute stage there was a high increase of IL-2, IFN, and TNF mRNA expression in both groups vs. controls, perforin and GrB varied in each group with patients in Group A having the highest values, and FasL was only expressed in Group A.
Positive_regulation (increase) of Transcription (expression) of TNF
18) Confidence 0.04 Published 2002 Journal Blood Cells Mol. Dis. Section Abstract Doc Link 12490285 Disease Relevance 0.30 Pain Relevance 0.29
Within minutes to hours of exposure to LPS, there is increased gene transcription and subsequent translation of cytokines and chemokines, prominently including tumor necrosis factor, interleukin-1, and interferons, as well as several enzymes; important among these are iNOS and cyclooxygenase 2 (COX-2) that catalyze the formation of NO and prostaglandin (PG) H2, respectively [4].
Positive_regulation (increased) of Transcription (transcription) of tumor necrosis factor associated with chemokine, necrosis, cancer, cox2 and cytokine
19) Confidence 0.02 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.33 Pain Relevance 0.28

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