INT49505

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2004
Negated 0
Speculated 0
Reported most in Title
Documents 6
Total Number 6
Disease Relevance 6.40
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH3) nucleoplasm (NOTCH3) extracellular region (NOTCH3)
plasma membrane (NOTCH3) nucleus (NOTCH3)
Anatomy Link Frequency
Notch 2
NOTCH3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 9 91.68 High High
headache 3 91.00 High High
cva 2 86.68 High High
imagery 3 85.00 Quite High
Disease Link Frequency Relevance Heat
Cadasil 21 100.00 Very High Very High Very High
Alopecia 6 99.76 Very High Very High Very High
Intervertebral Disk Displacement 6 98.96 Very High Very High Very High
Disease 2 96.76 Very High Very High Very High
Leukoencephalopathies 10 95.60 Very High Very High Very High
Death 1 93.60 High High
Dementia 8 92.48 High High
Stroke 5 92.32 High High
Migraine With Aura 5 91.68 High High
Headache 7 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic analysis showed strong linkage to the CADASIL locus for all seven families, suggesting genetic homogeneity.
CADASIL Binding (linkage) of associated with cadasil
1) Confidence 0.47 Published 1995 Journal Lancet Section Abstract Doc Link 7564728 Disease Relevance 1.91 Pain Relevance 0.36
[Report of a patient with CADASIL having a novel missense mutation of the Notch 3 gene--association with alopecia and lumbar herniated disk].
Notch 3 gene Binding (--association) of in Notch associated with intervertebral disk displacement, cadasil and alopecia
2) Confidence 0.37 Published 2001 Journal Rinsho Shinkeigaku Section Title Doc Link 11481859 Disease Relevance 1.40 Pain Relevance 0.26
[Report of a patient with CADASIL having a novel missense mutation of the Notch 3 gene--association with alopecia and lumbar herniated disk].
Notch 3 gene Binding (mutation) of in Notch associated with intervertebral disk displacement, cadasil and alopecia
3) Confidence 0.37 Published 2001 Journal Rinsho Shinkeigaku Section Title Doc Link 11481859 Disease Relevance 1.39 Pain Relevance 0.26
RESULTS: Genetic analysis strongly supported linkage to the CADASIL locus, and the disease haplotype was found in six individuals.
CADASIL Binding (linkage) of
4) Confidence 0.36 Published 1998 Journal Neurology Section Body Doc Link 9633716 Disease Relevance 0.23 Pain Relevance 0
[Clinical and neuroimaging findings in a family with CADASIL associated to C475T mutation].
CADASIL Binding (associated) of associated with cadasil
5) Confidence 0.36 Published 2004 Journal Rev Neurol Section Title Doc Link 14730489 Disease Relevance 0.56 Pain Relevance 0.09
How alterations in NOTCH3 lead to the CADASIL phenotype has yet to be elucidated.
CADASIL Binding (lead) of associated with cadasil
6) Confidence 0.36 Published 2004 Journal Panminerva Med Section Abstract Doc Link 15876982 Disease Relevance 0.92 Pain Relevance 0.06

General Comments

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