INT49506

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Context Info
Confidence 0.44
First Reported 1993
Last Reported 2010
Negated 3
Speculated 7
Reported most in Body
Documents 29
Total Number 42
Disease Relevance 17.38
Pain Relevance 6.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
inner ear 3
plasma 2
oocyte 2
granulosa cells 2
chondrocyte 1
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 345 100.00 Very High Very High Very High
agonist 323 100.00 Very High Very High Very High
addiction 2 100.00 Very High Very High Very High
Paracetamol 94 99.82 Very High Very High Very High
Inflammatory mediators 14 99.82 Very High Very High Very High
Endocannabinoid 14 99.76 Very High Very High Very High
bradykinin 1 99.68 Very High Very High Very High
Intracerebroventricular 14 98.08 Very High Very High Very High
Pain threshold 1 97.72 Very High Very High Very High
fibrosis 103 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 408 100.00 Very High Very High Very High
Hemophilus Infection 356 99.84 Very High Very High Very High
Granuloma 2 99.76 Very High Very High Very High
Injury 65 99.32 Very High Very High Very High
Disease 186 99.12 Very High Very High Very High
Bacterial Respiratory Disease 1 98.92 Very High Very High Very High
Bordatella Infection 1 98.48 Very High Very High Very High
Pain 10 97.72 Very High Very High Very High
Pulmonary Fibrosis 69 97.68 Very High Very High Very High
Neurological Disease 5 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A previous report suggested that EP2 and EP4 receptors were present in the cumulus, but not oocyte, of the mouse cumulus-oocyte complex [10].
Regulation (present) of EP2 in oocyte
1) Confidence 0.44 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
In both monkey and mouse oocytes, stimulation of EP2 and EP4 receptors increased cAMP as anticipated.
Regulation (stimulation) of EP2 in oocytes
2) Confidence 0.44 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Previous studies by this laboratory and others focused on granulosa cells as the primary target for PGE2 action within the periovulatory follicle.
Regulation (target) of PGE2 in follicle
3) Confidence 0.38 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
While PGE2 acts at both cumulus and mural granulosa cells of ovulatory follicles to promote periovulatory events [10,11], comparatively little is known about the oocyte as a target for PGE2 action.
Regulation (target) of PGE2 in granulosa cells
4) Confidence 0.38 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.07 Pain Relevance 0
Taken together, these findings support the concept that multiple cell types within the periovulatory follicle, including cumulus granulosa cells, mural granulosa cells, theca cells, and now oocytes, are potential targets for PGE2 action.
Regulation (targets) of PGE2 in granulosa cells
5) Confidence 0.38 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Recently, theca cells have also been suggested as a target for PGE2 action, with detection of mRNA for EP2, EP3, and EP4 in bovine theca [32] and EP2 mRNA in mouse theca cells [9].
Regulation (target) of PGE2 in theca
6) Confidence 0.38 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
The present study therefore examined the effects of EP2 and EP4 agonists on the modulation of inner ear VEGF levels.
Spec (examined) Regulation (effects) of EP2 in inner ear associated with agonist
7) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.26 Pain Relevance 0.24
Controls for EP2 agonist application were treated with saline, and controls for EP4 agonist application were treated with 0.01, 0.1, or 1% DMSO.
Regulation (Controls) of EP2 associated with agonist
8) Confidence 0.32 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0 Pain Relevance 0.44
To make such a conclusion, one needs to test whether selectively targeting EP2 would result in neuroprotection.
Spec (whether) Regulation (targeting) of EP2
9) Confidence 0.27 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.65 Pain Relevance 0.18
Here, we investigated the importance of the EP2 receptor in short- and long-term ischemic outcomes by subjecting wildtype (WT) and EP2 knockout (EP2-/-) mice to two distinct and complementary stroke models [transient and permanent middle cerebral artery occlusion (tMCAO and pMCAO)] and by using the EP2 receptor agonist ONO-AE1-259-01.


Spec (investigated) Regulation (importance) of EP2 receptor in middle cerebral artery associated with targeted disruption, middle cerebral artery infarction, stroke and agonist
10) Confidence 0.27 Published 2010 Journal Exp Transl Stroke Med Section Abstract Doc Link PMC2912268 Disease Relevance 0.38 Pain Relevance 0.04
To confirm that the inhibition of mitochondrial cationic dye release is modulated by stimulation of EP2, we examined the effect of the specific PKA inhibitor KT5720 (53) on PGE2-dependent inhibition of mitochondrial cationic dye release.
Spec (examined) Regulation (effect) of PGE2
11) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.19 Pain Relevance 0
The neuromodulatory effects of PGE(2) are mediated through regulation of four G-protein-coupled receptors known as EP1, EP2, EP3, and EP4.
Regulation (regulation) of EP2
12) Confidence 0.27 Published 2006 Journal J. Neurotrauma Section Abstract Doc Link 17184197 Disease Relevance 0.19 Pain Relevance 0.09
However, to our knowledge there have been no studies addressing the integrative signaling effects of the EP2 and FP receptors on signal transduction and gene expression.
Regulation (effects) of EP2
13) Confidence 0.25 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.39 Pain Relevance 0.08
Our findings identify EP2 receptor signaling as a novel proinflammatory and proamyloidogenic pathway in this model of AD, and suggest a rationale for development of therapeutics targeting the EP2 receptor in neuroinflammatory diseases such as AD.
Regulation (targeting) of EP2 receptor associated with disease
14) Confidence 0.25 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16267225 Disease Relevance 1.26 Pain Relevance 0.08
Role of prostaglandin E receptor subtypes EP2 and EP4 in autocrine and paracrine functions of vascular endothelial growth factor in the inner ear

Background

Regulation (Role) of EP2 in inner ear
15) Confidence 0.22 Published 2010 Journal BMC Neurosci Section Title Doc Link PMC2847564 Disease Relevance 0.13 Pain Relevance 0.11
We thus examined the expression of EP2 in the cochlea, and the effects of local EP2 and EP4 agonist application on the modulation of VEGF in the inner ear.
Spec (examined) Regulation (effects) of EP2 in inner ear associated with agonist
16) Confidence 0.22 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.52 Pain Relevance 0.23
COX-mediated neuronal injury is presumed be due to downstream effects of one or more prostaglandin products including PGE2, PGD2, PGF2alpha, PGI2 (prostacylin) and TXA2 (thromboxane) that effect cellular changes through activation of specific prostaglandin receptor subtypes and second messenger systems.
Regulation (effects) of PGE2 in neuronal associated with injury
17) Confidence 0.21 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17901552 Disease Relevance 1.42 Pain Relevance 0.35
Taken together, these findings support the concept that multiple cell types within the periovulatory follicle, including cumulus granulosa cells, mural granulosa cells, theca cells, and now oocytes, are potential targets for PGE2 action.
Regulation (targets) of PGE2 in theca cells
18) Confidence 0.13 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
None of the test samples showed any immediate effect in modulating the PGE2 level.
Regulation (modulating) of PGE2
19) Confidence 0.10 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.13 Pain Relevance 0
Thus the regulation of PGE2 and IL-6 production from murine decidua by LPS and inflammatory cytokines is similar to findings previously reported for human decidua.
Regulation (regulation) of PGE2 in decidua associated with inflammation and cytokine
20) Confidence 0.10 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8418915 Disease Relevance 0.87 Pain Relevance 0.34

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