INT49507

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Context Info
Confidence 0.16
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
paw 1
Ltc4s (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 3 96.00 Very High Very High Very High
Pain threshold 1 95.80 Very High Very High Very High
bradykinin 1 94.74 High High
Antinociceptive 2 88.32 High High
Inflammatory mediators 1 83.28 Quite High
Hyperalgesia 1 81.68 Quite High
IPN 1 75.00 Quite High
Analgesic 2 72.84 Quite High
Codeine 1 25.00 Low Low
Inflammation 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 2 96.00 Very High Very High Very High
Pressure And Volume Under Development 1 90.24 High High
Hyperalgesia 2 85.20 High High
INFLAMMATION 1 83.28 Quite High
Inflammatory Pain 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This compound was effective on PGE2, LTB4, bradykinin, PAF or IL-1 beta-induced decrease in pain threshold in the rat paw pressure model and almost totally suppressed the writhing induced by zymosan in mice, while peritoneal production of 6-ketoPGF1 alpha was inhibited by 48.5-62% and only at 100 mg/kg significant inhibition of LTC4 was achieved.
Negative_regulation (inhibition) of LTC4 in paw associated with pain threshold and bradykinin
1) Confidence 0.16 Published 1995 Journal Life Sci. Section Abstract Doc Link 7564876 Disease Relevance 0.61 Pain Relevance 0.59

General Comments

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