INT49519

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Context Info
Confidence 0.76
First Reported 1995
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 84
Total Number 86
Disease Relevance 36.88
Pain Relevance 34.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
microglia 9
nerves 5
vessels 3
neuronal 3
leukocytes 3
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 842 100.00 Very High Very High Very High
Pain 503 100.00 Very High Very High Very High
chemokine 452 100.00 Very High Very High Very High
substance P 25 100.00 Very High Very High Very High
Neuropathic pain 332 99.96 Very High Very High Very High
cytokine 248 99.96 Very High Very High Very High
Central nervous system 219 99.96 Very High Very High Very High
Potency 435 99.92 Very High Very High Very High
Hippocampus 176 99.84 Very High Very High Very High
Spinal cord 221 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 581 100.00 Very High Very High Very High
Nervous System Injury 247 99.98 Very High Very High Very High
Neuropathic Pain 722 99.96 Very High Very High Very High
Injury 322 99.92 Very High Very High Very High
INFLAMMATION 1284 99.54 Very High Very High Very High
Cv Unclassified Under Development 132 99.28 Very High Very High Very High
Hyperalgesia 290 99.20 Very High Very High Very High
Alzheimer's Dementia 32 98.88 Very High Very High Very High
Ganglion Cysts 69 98.56 Very High Very High Very High
Motor Neuron Diseases 4 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A-804598 also potently blocked agonist stimulated release of IL-1beta and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.
Gene_expression (express) of P2X7 in THP-1 associated with agonist
1) Confidence 0.76 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 18602931 Disease Relevance 0.32 Pain Relevance 0.52
Following oATP treatment, there was a reduction in P2X7 expression in the endings of peripheral nerves, as well as in endothelial cells.
Gene_expression (expression) of P2X7 in endothelial cells
2) Confidence 0.74 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12483745 Disease Relevance 0.11 Pain Relevance 0
A-804598 was tritiated ([3H]A-804598; 8.1Ci/mmol) and utilized to study recombinant rat P2X7 receptors expressed in 1321N1 cells. [3H]A-804598 labeled a single class of high affinity binding sites (Kd=2.4 nM and apparent Bmax=0.56 pmol/mg).
Gene_expression (expressed) of P2X7 in 1321N1
3) Confidence 0.59 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 18602931 Disease Relevance 0.30 Pain Relevance 0.53
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Gene_expression (expressing) of P receptor in spinal associated with hyperalgesia, qutenza and substance p
4) Confidence 0.58 Published 1997 Journal Science Section Title Doc Link 9323204 Disease Relevance 0.28 Pain Relevance 0.95
Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia.
Gene_expression (express) of P receptor in lamina associated with hyperalgesia, substance p and spinal cord
5) Confidence 0.58 Published 1997 Journal Science Section Abstract Doc Link 9323204 Disease Relevance 0.35 Pain Relevance 0.74
When a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor.
Gene_expression (express) of P receptor in spinal cord neurons associated with spinal cord and substance p
6) Confidence 0.58 Published 1997 Journal Science Section Abstract Doc Link 9323204 Disease Relevance 0.25 Pain Relevance 0.73
Taken together, the present study demonstrated functional expression of P2X7 receptors in non-neuronal but not in small diameter neurons from rat DRG.
Gene_expression (expression) of P2X7 in neuronal
7) Confidence 0.57 Published 2005 Journal Brain Res. Section Abstract Doc Link 16005856 Disease Relevance 0 Pain Relevance 0.12
The P2X7 receptor is an ATP-sensitive ligand-gated cation channel, expressed predominantly in cells with immune origin.
Gene_expression (expressed) of P2X7
8) Confidence 0.57 Published 2005 Journal Brain Res. Section Abstract Doc Link 16005856 Disease Relevance 0.09 Pain Relevance 0.12
In the present study, the expression of P2X7 receptors in non-neuronal cells and neurons isolated from dorsal root ganglia was characterized using patch clamp, pharmacological and confocal microscopy approaches.
Gene_expression (expression) of P2X7 in neurons
9) Confidence 0.57 Published 2005 Journal Brain Res. Section Abstract Doc Link 16005856 Disease Relevance 0.10 Pain Relevance 0.13
Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia.
Gene_expression (expression) of P2X7 in neuronal
10) Confidence 0.57 Published 2005 Journal Brain Res. Section Title Doc Link 16005856 Disease Relevance 0.09 Pain Relevance 0.16
Indeed, oATP could block such amplifying mechanism of inflammation and also downregulate P2X7 receptor expression, especially in vessels and nerves close to the site of inflammation (see Fig 4).
Gene_expression (expression) of P2X7 receptor in nerves associated with inflammation
11) Confidence 0.48 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.43 Pain Relevance 0.26
Histologic expression of P2X7 receptors and HIS36
Gene_expression (expression) of P2X7
12) Confidence 0.48 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.12 Pain Relevance 0.38
Treatment with local oATP, alone or after inflammatory reaction induced by carrageenan, showed a focal, irregular and mild reduction of P2X7 expression, often more prominent in areas with phlogosis both in nerves and in vessels.
Gene_expression (expression) of P2X7 in nerves associated with inflammation
13) Confidence 0.48 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.34 Pain Relevance 0.17
In inflamed paws the expression of P2X7 receptors was less evident in oATP-treated than in untreated rats, independently on the route of oATP administration.
Gene_expression (expression) of P2X7
14) Confidence 0.48 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.42 Pain Relevance 0.34
These data confirm the strict correlation between P2X7 expression by leukocytes and relative inflammatory response and underline that the reduction of inflammatory effects due to oATP administration is similar to that observed in P2X7 receptor deficient mice [33].
Gene_expression (expression) of P2X7 in leukocytes associated with inflammatory response and inflammation
15) Confidence 0.48 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.47 Pain Relevance 0.36
As reported in Fig. 4, an intense expression for P2X7 receptors was observed in nerve endings and peripheral nerves of control saline-treated rat hind paws.
Gene_expression (expression) of P2X7 in peripheral nerves
16) Confidence 0.48 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.19 Pain Relevance 0.36
Our previous data suggested the possibility that the block of P2X7 receptors expressed by nerve terminals could be useful to inhibit pain transmission [3].
Gene_expression (expressed) of P2X7 in nerve associated with pain
17) Confidence 0.48 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.42 Pain Relevance 0.35
We analysed in parallel the expression of some chemokines (MCP-1, IP 10 and IL 8) and the expression of P2X7 receptors in the same inflamed tissues and their modifications due to oATP treatment.
Gene_expression (expression) of P2X7 associated with chemokine
18) Confidence 0.48 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.50 Pain Relevance 0.62
Few arterial vessels had a weak P2X7 positivity with a more prominent reduction in P2X7 expression in areas close to the inflammation site.
Gene_expression (expression) of P2X7 in vessels associated with inflammation
19) Confidence 0.42 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.36 Pain Relevance 0.29
Hind paws treated with intravenous oATP, alone or after inflammatory reaction induced by carrageenan, presented a reduced expression of P2X7, either in nerves, or close to epidermidis, in dermis or intramuscolar.
Gene_expression (expression) of P2X7 in dermis associated with inflammation
20) Confidence 0.42 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.34 Pain Relevance 0.30

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