INT49520

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 5
Speculated 4
Reported most in Abstract
Documents 121
Total Number 129
Disease Relevance 61.15
Pain Relevance 49.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 26
sensory neurons 11
oocytes 7
DRG 7
ganglia 6
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 978 100.00 Very High Very High Very High
Pain 969 100.00 Very High Very High Very High
qutenza 688 100.00 Very High Very High Very High
nociceptor 461 100.00 Very High Very High Very High
antagonist 342 100.00 Very High Very High Very High
ASIC 255 100.00 Very High Very High Very High
Calcitonin gene-related peptide 221 100.00 Very High Very High Very High
substance P 92 100.00 Very High Very High Very High
Dorsal horn 154 99.96 Very High Very High Very High
Intractable pain 8 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2405 100.00 Very High Very High Very High
Pain 1062 100.00 Very High Very High Very High
Nociception 930 100.00 Very High Very High Very High
Intractable Pain 8 99.92 Very High Very High Very High
Nervous System Injury 413 99.76 Very High Very High Very High
Arrhythmia Under Development 8 99.76 Very High Very High Very High
Myocardial Infarction 24 99.70 Very High Very High Very High
Cancer Pain 4 99.64 Very High Very High Very High
INFLAMMATION 287 99.54 Very High Very High Very High
Mouth Cancer 4 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heterogeneity of the functional expression of P2X3 and P2X2/3 receptors in the primary nociceptive neurons of rat.
Gene_expression (expression) of P2X3 in neurons associated with nociception and pain
1) Confidence 0.78 Published 2001 Journal Neurochem. Res. Section Title Doc Link 11699951 Disease Relevance 0.19 Pain Relevance 0.14
Here, we tested the hypothesis that adenosine triphosphate is one such key mediator through actions on P2X3 and P2X2/3 receptors, which are expressed selectively on primary afferent nocioceptors, including those innervating the bone.
Gene_expression (expressed) of P2X3 associated with adenocard
2) Confidence 0.78 Published 2010 Journal Brain Section Abstract Doc Link 20802203 Disease Relevance 0.71 Pain Relevance 0.67
Visceral sensory neurons that innervate both uterus and colon express nociceptive TRPv1 and P2X3 receptors in rats.
Gene_expression (express) of P2X3 in sensory neurons associated with nociception and nociceptor
3) Confidence 0.77 Published 2008 Journal Ethn Dis Section Title Doc Link 18646315 Disease Relevance 1.29 Pain Relevance 0.78
We found that viscerally labeled DRGs express nociceptive P2X3 and TRPV1 receptors.
Gene_expression (express) of P2X3 associated with nociception
4) Confidence 0.77 Published 2008 Journal Ethn Dis Section Abstract Doc Link 18646315 Disease Relevance 1.07 Pain Relevance 0.65
On the other hand, inflammation caused a twofold to threefold increase in both ATP-activated currents, altered the voltage dependence of P2X receptors, and enhanced the expression of P2X2 and P2X3 receptors.
Gene_expression (expression) of P2X3 associated with addiction and inflammation
5) Confidence 0.75 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11756492 Disease Relevance 0.89 Pain Relevance 0.68
P2X3 is the only ligand-gated channel known to be expressed exclusively by a subset of sensory neurons.
Gene_expression (expressed) of P2X3 in sensory neurons
6) Confidence 0.75 Published 1995 Journal Nature Section Abstract Doc Link 7566119 Disease Relevance 0.09 Pain Relevance 0.30
Here we report the molecular cloning and characterization of a new member of the P2X receptor family, P2X3, expressed by these cells.
Gene_expression (expressed) of P2X3
7) Confidence 0.75 Published 1995 Journal Nature Section Abstract Doc Link 7566119 Disease Relevance 0.09 Pain Relevance 0.22
Immunocytochemical studies revealed that P2X3 receptors are expressed in small and medium but rarely in large DRG neurons of both normal and SNI rats.
Gene_expression (expressed) of P2X3 in neurons associated with nervous system injury
8) Confidence 0.73 Published 2005 Journal Pain Section Abstract Doc Link 16298067 Disease Relevance 1.08 Pain Relevance 0.38
The expression of P2X3 receptors on the cell membrane is significantly enhanced while the total expression of P2X3 receptors remained unchanged.
Gene_expression (expression) of P2X3
9) Confidence 0.73 Published 2005 Journal Pain Section Abstract Doc Link 16298067 Disease Relevance 0.76 Pain Relevance 0.37
The expression of P2X3 receptors on the cell membrane is significantly enhanced while the total expression of P2X3 receptors remained unchanged.
Gene_expression (expression) of P2X3
10) Confidence 0.73 Published 2005 Journal Pain Section Abstract Doc Link 16298067 Disease Relevance 0.90 Pain Relevance 0.39
In summary, our results suggest that P2X3 is expressed by a functionally heterogeneous population of BSI-B4-binding sensory neurons, and is transported into both central and peripheral processes of these neurons.
Gene_expression (expressed) of P2X3 in sensory neurons
11) Confidence 0.73 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9824460 Disease Relevance 0 Pain Relevance 0.43
P2X3 is expressed by DRG neurons that terminate in inner lamina II.
Gene_expression (expressed) of P2X3 in lamina associated with qutenza
12) Confidence 0.73 Published 1998 Journal Eur. J. Neurosci. Section Title Doc Link 9824460 Disease Relevance 0 Pain Relevance 0.41
In order to obtain such a specific inhibitor, a variety of antisense oligonucleotides (ASO) against rat P2X3 was tested, and dose-dependent, sequence-specific downregulation of the rat P2X3 receptor (expressed in a Chinese hamster ovary cell line [CHO-K1]) on the mRNA, protein, and functional levels was observed.
Gene_expression (expressed) of P2X3 in ovary
13) Confidence 0.68 Published 2001 Journal Antisense Nucleic Acid Drug Dev. Section Abstract Doc Link 11446592 Disease Relevance 0.09 Pain Relevance 0.09
The expression of P2X3 mRNA and protein in the ischemic injury heart were higher than that in the naive heart as control.
Gene_expression (expression) of P2X3 in heart associated with heart injuries
14) Confidence 0.68 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 1.13 Pain Relevance 0.16
A-317491 reduced the expression of P2X3 mRNA and protein in the myocardial ischemic injury.
Gene_expression (expression) of P2X3 associated with myocardial infarction
15) Confidence 0.68 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 1.14 Pain Relevance 0.15
The expression of P2X3 immunoreactivity, mRNA and protein were analyzed by immunohistochemistry, in situ hybridization and western blotting.
Spec (analyzed) Gene_expression (expression) of P2X3
16) Confidence 0.68 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 0.93 Pain Relevance 0.16
Using a well-established rat model of bone cancer pain, AF-353, a recently described potent and selective P2X3 and P2X2/3 receptor antagonist, was administered orally to rats and found to produce highly significant prevention and reversal of bone cancer pain behaviour.
Gene_expression (produce) of P2X3 associated with cancer pain, antagonist and bone cancer
17) Confidence 0.68 Published 2010 Journal Brain Section Abstract Doc Link 20802203 Disease Relevance 0.81 Pain Relevance 0.77
Moreover, ATP opens ligand-gated ion channels (P2X receptors) in sensory neurons and only sensory neurons express messenger RNA for the P2X3 receptor.
Gene_expression (express) of P2X3 in sensory neurons
18) Confidence 0.67 Published 1997 Journal Nature Section Abstract Doc Link 9168113 Disease Relevance 0.71 Pain Relevance 0.64
It has been reported that proteinase-activated receptor 2 (PAR2) receptor activation enhances the animal's pain response and PAR2 coexpresses with P2X3 in dorsal root ganglion neurons.
Gene_expression (coexpresses) of P2X3 in neurons associated with ganglion cysts, pain and root ganglion neuron
19) Confidence 0.65 Published 2010 Journal Neuroreport Section Abstract Doc Link 20118742 Disease Relevance 0.41 Pain Relevance 0.32
Superfusion of the selective P2X1, P2X3 and P2X(2/3) receptor antagonist 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (6-638 microM) partially blocked the Vc central sensitization.
Gene_expression (Superfusion) of P2X3 associated with adenocard, central sensitization and antagonist
20) Confidence 0.59 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15901761 Disease Relevance 0.23 Pain Relevance 0.65

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