INT49521

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Context Info
Confidence 0.04
First Reported 1995
Last Reported 1998
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.22
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rtcd1) molecular_function (Rtcd1) ligase activity (Rtcd1)
Anatomy Link Frequency
skin 1
Rtcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 6 99.36 Very High Very High Very High
Neuropeptide 1 97.92 Very High Very High Very High
Central nervous system 1 97.48 Very High Very High Very High
antagonist 6 96.98 Very High Very High Very High
Dynorphin 1 96.80 Very High Very High Very High
Opioid 4 95.66 Very High Very High Very High
agonist 8 93.36 High High
opioid receptor 5 92.56 High High
Sumatriptan 1 92.54 High High
Morphine 4 91.04 High High
Disease Link Frequency Relevance Heat
Thymoma 4 75.00 Quite High
Hyperalgesia 1 68.64 Quite High
Bordatella Infection 2 42.40 Quite Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether kappa opioid receptor function was maintained by spare receptors after agonist-induced down-regulation, membranes from untreated R1.1 cells were incubated with 400 nM of the irreversible opioid antagonist beta-chlornaltrexamine (beta-CNA) followed by extensive washing. beta-CNA produced a 50% reduction in the [3H]U69,593 binding and a 6-fold increase in the IC50 value for (-)-U50,488 inhibition of adenylyl cyclase activity, with no change in the maximal inhibition of cyclic AMP levels.
cyclase Binding (activity) of associated with antagonist, agonist, kappa opioid receptor and opioid
1) Confidence 0.04 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7891351 Disease Relevance 0.07 Pain Relevance 0.44
The R1.1 cell line and its derivatives, R1.G1 and R1EGO, express a similar type of kappa opioid receptor, which exhibits differences in coupling to G-proteins and to adenylyl cyclase among cell lines.
cyclase Binding (coupling) of associated with kappa opioid receptor
2) Confidence 0.04 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7840787 Disease Relevance 0.07 Pain Relevance 0.23
Here we report the isolation, on the basis of its ability to inhibit the cyclase in a stable recombinant CHO(ORL1+) cell line, of a neuropeptide that resembles dynorphin A9 and whose amino acid sequence is Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln.
cyclase Neg (inhibit) Binding (inhibit) of associated with dynorphin and neuropeptide
3) Confidence 0.01 Published 1995 Journal Nature Section Abstract Doc Link 7566152 Disease Relevance 0.07 Pain Relevance 0.36
The effects of agonists and antagonists comprised: (i) agonist potencies in the order 5-carboxamidotryptamine > 5-HT > sumatriptan > 8-hydroxy-2-(di-n-propylamino)tetralin; (ii) inhibition of contractile action of 5-HT by the 5-HT1D antagonist GR 127935; (iii) a contractile response to methysergide; (iv) a lack of effect of tropisetron, an antagonist of 5-HT3 and 5-HT4 receptors; and (v) inhibition of forskolin-stimulated cAMP formation by 5-HT (in the presence of LY 53857), indicative of negative coupling to adenylate cyclase. 4.
cyclase Neg (negative) Binding (coupling) of associated with sumatriptan, antagonist and agonist
4) Confidence 0.00 Published 1998 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 9590577 Disease Relevance 0 Pain Relevance 0.46
These results suggest that L-Arg increases transport in toad skin presumably acting through the formation of nitric oxide, which then stimulates cytoplasmic guanylate cyclase and leads to increased Na+ and K+ transport.
cyclase Binding (leads) of in skin
5) Confidence 0.00 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8982659 Disease Relevance 0 Pain Relevance 0.40

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