INT49532

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Context Info
Confidence 0.61
First Reported 1993
Last Reported 2010
Negated 7
Speculated 5
Reported most in Abstract
Documents 43
Total Number 49
Disease Relevance 25.80
Pain Relevance 14.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 6
macrophages 4
brain 4
sciatic nerve 4
adipose tissue 3
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 284 100.00 Very High Very High Very High
agonist 242 100.00 Very High Very High Very High
cytokine 184 100.00 Very High Very High Very High
Pain 37 100.00 Very High Very High Very High
Spinal cord 16 100.00 Very High Very High Very High
Analgesic 15 100.00 Very High Very High Very High
ketamine 10 100.00 Very High Very High Very High
Dorsal horn 10 100.00 Very High Very High Very High
allodynia 5 100.00 Very High Very High Very High
tramadol 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 379 100.00 Very High Very High Very High
Pain 33 100.00 Very High Very High Very High
Neuropathic Pain 17 100.00 Very High Very High Very High
Pancreatitis 12 100.00 Very High Very High Very High
Adhesions 7 100.00 Very High Very High Very High
Hyperalgesia 6 100.00 Very High Very High Very High
Obesity 106 99.98 Very High Very High Very High
Endotoxemia 9 99.68 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

1 99.00 Very High Very High Very High
Disease 71 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several lines of evidence obtained in the laboratory have shown that the brain significantly modulates IL-6 production in the periphery.
Regulation (modulates) of Gene_expression (production) of IL-6 in brain
1) Confidence 0.61 Published 1998 Journal Neuroimmunomodulation Section Abstract Doc Link 9730688 Disease Relevance 0.80 Pain Relevance 0.14
Effects of training on exercise-induced muscle damage and interleukin 6 production.
Regulation (Effects) of Gene_expression (production) of interleukin 6 in muscle
2) Confidence 0.56 Published 1999 Journal Muscle Nerve Section Title Doc Link 10024133 Disease Relevance 0.16 Pain Relevance 0.08
Effect of RAR-selective agonists on IL-1-induced expression of IL-6
Regulation (Effect) of Gene_expression (expression) of IL-6 associated with agonist
3) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.05 Pain Relevance 0.43
In contrast, BMS-649 (RXR agonist) was ineffective on IL-6 expression or production (Figure 2a,b).
Regulation (ineffective) of Gene_expression (expression) of IL-6 associated with agonist
4) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.06 Pain Relevance 0.33
In our study only systemic levels of IL-6 were measured and they could be an overspill of the local IL-6 [29] and we therefore assumed that systemic IL-6 levels correlate with local IL-6 levels.
Regulation (correlate) of Gene_expression (levels) of IL-6
5) Confidence 0.45 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 1.19 Pain Relevance 0.38
In our study only systemic levels of IL-6 were measured and they could be an overspill of the local IL-6 [29] and we therefore assumed that systemic IL-6 levels correlate with local IL-6 levels.
Regulation (correlate) of Gene_expression (levels) of IL-6
6) Confidence 0.45 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 1.13 Pain Relevance 0.35
Patients suffering from persisting sciatic pain 8 weeks following discectomy were compared with patients displaying low complaints and healthy, pain-free volunteers regarding their interleukin-6 (IL-6) levels, morning cortisol levels and degree of psychological distress.
Regulation (regarding) of Gene_expression (levels) of interleukin-6 associated with pain
7) Confidence 0.45 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9453216 Disease Relevance 0.47 Pain Relevance 0.33
Adrenaline, noradrenaline, cortisol and glucose levels were significantly lower with TIVA than VIMA, but there was no difference in IL-6 levels between the two groups.
Neg (no) Regulation (difference) of Gene_expression (levels) of IL-6 associated with noradrenaline
8) Confidence 0.45 Published 2009 Journal J. Int. Med. Res. Section Abstract Doc Link 20146874 Disease Relevance 0.15 Pain Relevance 0.38
Patients suffering from persisting sciatic pain 8 weeks following discectomy were compared with patients displaying low complaints and healthy, pain-free volunteers regarding their interleukin-6 (IL-6) levels, morning cortisol levels and degree of psychological distress.
Regulation (regarding) of Gene_expression (levels) of IL-6 associated with pain
9) Confidence 0.45 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9453216 Disease Relevance 0.47 Pain Relevance 0.33
Is there a relation between urinary interleukin-6 levels and symptoms before and after intra-vesical glycosaminoglycan substitution therapy in patients with bladder pain syndrome/interstitial cystitis?
Regulation (relation) of Gene_expression (levels) of interleukin-6 in bladder associated with pain and interstitial cystitis
10) Confidence 0.44 Published 2007 Journal Int Urogynecol J Pelvic Floor Dysfunct Section Title Doc Link 17982709 Disease Relevance 0.46 Pain Relevance 0.50
Effects of formalin-induced pain on ACTH, beta-endorphin, corticosterone and interleukin-6 plasma levels in rats.
Regulation (Effects) of Gene_expression (levels) of interleukin-6 in plasma associated with pain
11) Confidence 0.43 Published 1995 Journal Neuroendocrinology Section Title Doc Link 7566433 Disease Relevance 0.43 Pain Relevance 0.45
Effects of ketamine on serum and tracheobronchial aspirate interleukin-6 levels in infants undergoing cardiac surgery.
Regulation (Effects) of Gene_expression (levels) of interleukin-6 associated with ketamine and analgesic
12) Confidence 0.42 Published 2005 Journal J. Cardiothorac. Vasc. Anesth. Section Title Doc Link 16130059 Disease Relevance 0.19 Pain Relevance 0.45
This study aimed to determine the effect of sirolimus on hyperalgesia and allodynia and on serum and spinal cord TNF-alpha, IL-1beta and IL-6 levels in rat neuropathic pain.
Spec (determine) Regulation (effect) of Gene_expression (levels) of IL-6 in spinal cord associated with hyperalgesia, allodynia, neuropathic pain and spinal cord
13) Confidence 0.41 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20600616 Disease Relevance 1.17 Pain Relevance 1.25
After intracerebroventricular IL-1 beta, IL-6 levels in brain areas (striatum, hippocampus, hypothalamus) were extremely low, suggesting that the brain does not significantly contribute to IL-6 synthesis in this condition.
Neg (not) Regulation (contribute) of Gene_expression (synthesis) of IL-6 in brain associated with hippocampus and intracerebroventricular
14) Confidence 0.40 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8238440 Disease Relevance 0.07 Pain Relevance 0.59
Since thalidomide mainly inhibits tumor necrosis factor alpha (TNF-alpha) synthesis with less well defined effects on other cytokines, we investigated the effect of the drug on the expression of the proinflammatory cytokines TNF-alpha, interleukin-1beta (IL-1beta) and interleukin 6 (IL-6), and of the anti-inflammatory cytokine interleukin-10 (IL-10) in the lesioned rat sciatic nerve.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of interleukin 6 in sciatic nerve associated with necrosis, inflammation, cancer, sciatic nerve and cytokine
15) Confidence 0.37 Published 2000 Journal Pain Section Abstract Doc Link 11068114 Disease Relevance 1.03 Pain Relevance 0.63
Since thalidomide mainly inhibits tumor necrosis factor alpha (TNF-alpha) synthesis with less well defined effects on other cytokines, we investigated the effect of the drug on the expression of the proinflammatory cytokines TNF-alpha, interleukin-1beta (IL-1beta) and interleukin 6 (IL-6), and of the anti-inflammatory cytokine interleukin-10 (IL-10) in the lesioned rat sciatic nerve.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of IL-6 in sciatic nerve associated with necrosis, inflammation, cancer, sciatic nerve and cytokine
16) Confidence 0.37 Published 2000 Journal Pain Section Abstract Doc Link 11068114 Disease Relevance 1.04 Pain Relevance 0.63
Genetic polymorphisms may be important in influencing the expression of cytokines, such as interleukin-6 (IL-6).
Regulation (influencing) of Gene_expression (expression) of interleukin-6 associated with cytokine
17) Confidence 0.37 Published 2004 Journal Am. J. Cardiol. Section Abstract Doc Link 15342284 Disease Relevance 0.26 Pain Relevance 0.33
Hypothalamic IL-6 expression was detected in the hypothalamus of diet-induced obesity (DIO) rats; however, a 156% increase was observed in the DIO rats after acute exercise (Figure 7a).
Regulation (detected) of Gene_expression (expression) of IL-6 in hypothalamus associated with obesity
18) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 1.05 Pain Relevance 0
The expression of interleukin (IL)-1alpha, IL-1beta, IL-6, macrophage inflammatory protein-2, interferon-gamma, and tumor necrosis factor-alpha was measured by semiquantitative reverse-transcription polymerase chain reaction.
Regulation (measured) of Gene_expression (expression) of IL-6 in macrophage
19) Confidence 0.29 Published 1999 Journal Anesthesiology Section Body Doc Link 10598627 Disease Relevance 0 Pain Relevance 0
There were no changes in expression of other cytokines of the IL-6 family.
Neg (no) Regulation (changes) of Gene_expression (expression) of IL-6 associated with cytokine
20) Confidence 0.28 Published 2010 Journal Peptides Section Abstract Doc Link 19799952 Disease Relevance 0.13 Pain Relevance 0.25

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