INT49536

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Context Info
Confidence 0.38
First Reported 1995
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 3.89
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
sensory neurons 2
neuronal 2
hearts 2
hippocampus 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 97 99.56 Very High Very High Very High
Hippocampus 4 97.72 Very High Very High Very High
ischemia 50 97.04 Very High Very High Very High
ASIC 24 95.48 Very High Very High Very High
Glutamate 6 95.28 Very High Very High Very High
nMDA receptor 9 84.64 Quite High
anesthesia 2 83.84 Quite High
halothane 6 72.64 Quite High
substance P 10 70.68 Quite High
isoflurane 1 70.64 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 552 100.00 Very High Very High Very High
Acidosis 150 100.00 Very High Very High Very High
Cv Unclassified Under Development 66 97.04 Very High Very High Very High
Coronary Heart Disease 13 95.00 High High
Myocardial Infarction 5 93.56 High High
Nociception 7 85.60 High High
Alkalosis 6 85.00 Quite High
Sepsis 15 84.32 Quite High
Stress 17 80.72 Quite High
Pain 10 65.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of anoxic aglycemia on Ca2+ regulation
Regulation (Effects) of Regulation (regulation) of Ca2
1) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.61 Pain Relevance 0
In the present study, we have therefore investigated the effects of acidosis on intracellular Ca2+ regulation in small, capsaicin-sensitive, sensory neurones (15–30 ?
Spec (investigated) Regulation (effects) of Spec (investigated) Regulation (regulation) of Ca2 associated with acidosis and qutenza
2) Confidence 0.37 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.80 Pain Relevance 0.45
There were no significant changes in L-type Ca2+ channel and calsequestrin mRNA transcription levels when hypoxia-reoxygenated cells were treated with thiopental.
Neg (no) Regulation (changes) of Neg (no) Regulation (changes) of Ca2 associated with hypoxia
3) Confidence 0.26 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.56 Pain Relevance 0
Microfluorimetry with the calcium-sensitive dye fura-2 was used to study the effects of four anesthetic agents on the regulation of intracellular free Ca2+ in hippocampal neurons cultured from the embryonic rat hippocampus.
Regulation (effects) of Regulation (regulation) of Ca2 in hippocampus associated with hippocampus
4) Confidence 0.24 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7566489 Disease Relevance 0 Pain Relevance 0.20
These data clearly show that loss of oxygen, and exhaustion of glycolytic substrates, can profoundly affect many aspects of cell Ca2+ regulation, and this may play an important role in modulating neuronal responses to ischemia.



Regulation (affect) of Regulation (regulation) of Ca2 in neuronal associated with ischemia
5) Confidence 0.23 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.51 Pain Relevance 0.05
In this study, we have investigated the effects of anoxia and anoxic aglycemia on Ca2+ regulation in sensory neurons from rat dorsal root ganglia.
Spec (investigated) Regulation (effects) of Spec (investigated) Regulation (regulation) of Ca2 in sensory neurons associated with hypoxia
6) Confidence 0.23 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.68 Pain Relevance 0.14
In contrast to young LPS rats (0.5 and 5 mg/kg LPS), myofilament Ca2+ sensitivity was unaltered in senescent LPS hearts.
Regulation (unaltered) of Regulation (sensitivity) of Ca2 in hearts
7) Confidence 0.18 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1750995 Disease Relevance 0.54 Pain Relevance 0
Effects of phosphorylation on Ca2+-sensitivity
Regulation (sensitivity) of Regulation (Effects) of Ca2
8) Confidence 0.16 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.19 Pain Relevance 0.03
Whether these presynaptic P2Y receptors affected transmitter release through a modulation of Ca2+ or K+ channels remained unfortunately unknown.
Spec (Whether) Regulation (affected) of Regulation (modulation) of Ca2
9) Confidence 0.05 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.26

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