INT49538

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 22
Total Number 27
Disease Relevance 2.66
Pain Relevance 13.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
neurons 2
plasma 1
brain 1
boutons 1
platelet 1
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 133 100.00 Very High Very High Very High
antagonist 112 100.00 Very High Very High Very High
intrathecal 17 100.00 Very High Very High Very High
anesthesia 12 100.00 Very High Very High Very High
Morphine 10 100.00 Very High Very High Very High
Pain 10 100.00 Very High Very High Very High
Versed 3 100.00 Very High Very High Very High
Analgesic 7 99.98 Very High Very High Very High
lidocaine 10 99.76 Very High Very High Very High
Antinociceptive 6 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 9 98.72 Very High Very High Very High
INFLAMMATION 28 97.24 Very High Very High Very High
Inflammatory Pain 31 96.56 Very High Very High Very High
Nociception 14 95.24 Very High Very High Very High
Aging 116 95.12 Very High Very High Very High
Drug Dependence 4 94.56 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 90.96 High High
Opiate Addiction 1 90.44 High High
Anxiety Disorder 6 70.08 Quite High
Neuropathic Pain 3 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings suggest that GluR2 is almost universally present at AMPA-containing synapses, whereas GluR1 is preferentially associated with primary afferent terminals.
GluR1 Binding (associated) of in synapses
1) Confidence 0.47 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.30
The studies revealed that while GluR1 is mainly associated with dendritic and somatic spines, GluR2/3 is mostly present in the perisomatic area.
GluR1 Binding (associated) of in spines
2) Confidence 0.47 Published 1997 Journal Synapse Section Abstract Doc Link 9068124 Disease Relevance 0 Pain Relevance 0.36
We designed this study to evaluate the antinociceptive effects of a non-NMDA glutamate receptor antagonist and its interaction with lidocaine in rats.
glutamate receptor Binding (interaction) of associated with antagonist, glutamate receptor, lidocaine and antinociceptive
3) Confidence 0.42 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10439758 Disease Relevance 0 Pain Relevance 1.27
Evidence that these puncta represented synaptic receptors was obtained with electron microscopy and by examining the association of GluR2- and GluR1-immunoreactive puncta with glutamatergic boutons (identified with vesicular glutamate transporters or markers for unmyelinated afferents).
GluR1-immunoreactive Spec (examining) Binding (association) of in boutons associated with glutamate and unmyelinated
4) Confidence 0.37 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.36
In addition, GluR1 ASO hinders the BDNF/mTOR dependent increase in GluR1 in synaptic plasma membranes and causes a clear-cut LTM deficit 24 h after training.
GluR1 ASO Spec (clear) Binding (hinders) of in plasma
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.07
Prolonged activity blockade (1-3 days) with an AMPA receptor antagonist increased cell surface (synaptic and extrasynaptic) glutamate receptor 1 (GluR1) and GluR2 but not GluR3, as well as GluR1/2 co-localization on the cell surface and total GluR1 and GluR2 protein levels.
glutamate receptor 1 Neg (not) Binding (blockade) of associated with glutamate receptor and antagonist
6) Confidence 0.36 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.09 Pain Relevance 0.57
Prolonged activity blockade (1-3 days) with an AMPA receptor antagonist increased cell surface (synaptic and extrasynaptic) glutamate receptor 1 (GluR1) and GluR2 but not GluR3, as well as GluR1/2 co-localization on the cell surface and total GluR1 and GluR2 protein levels.
GluR1 Neg (not) Binding (blockade) of associated with glutamate receptor and antagonist
7) Confidence 0.36 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.09 Pain Relevance 0.58
An autoradiographic study of [3H]AMPA receptor binding and in situ hybridization of AMPA sensitive glutamate receptor A (GluR-A) subunits following morphine withdrawal in the rat brain.
GluR-A Binding (binding) of in brain associated with glutamate receptor, withdrawal and morphine
8) Confidence 0.35 Published 2000 Journal Brain Res. Bull. Section Title Doc Link 10822164 Disease Relevance 0.18 Pain Relevance 0.89
While prominent perikaryal GluR1 immunolabelling was observed only in a small population of interneurons, sparse perikaryal GluR1 immunolabelling was found associated with the rough endoplasmic reticulum, the Golgi apparatus, the outer membranes of the mitochondria, and the outer envelope of the nucleus of about 30% of striatal projection neurons (identified by their non-indented nuclei).
GluR1 Binding (associated) of in projection neurons associated with projection neuron
9) Confidence 0.32 Published 1998 Journal Neuroscience Section Abstract Doc Link 9483559 Disease Relevance 0 Pain Relevance 0.63
These results suggest that: (1) AMPA receptor-expressing neurons appear to be the exclusive recipient of hypothalamic Leu-enkephalin boutons; (2) these enkephalinoceptive neurons contain both GluR1 and GluR2/3 AMPA receptor subunits; however, (3) only the GluR2/3 subtype, located in the perisomatic area, may be associated with Leu-enkephalin-containing inputs.
GluR1 Binding (contain) of in neurons associated with enkephalin
10) Confidence 0.32 Published 1997 Journal Synapse Section Abstract Doc Link 9068124 Disease Relevance 0 Pain Relevance 0.43
Here we show that consolidation of inhibitory avoidance (IA) LTM entails mTOR activation in the dorsal hippocampus at the moment of and 3 h after training and is associated with a rapid and rapamycin-sensitive increase in AMPA receptor GluR1 subunit expression, which was also blocked by intra-hippocampal delivery of GluR1 antisense oligonucleotides (ASO).
GluR1 Binding (associated) of in hippocampus associated with hippocampus
11) Confidence 0.31 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.07 Pain Relevance 0.05
Prolonged activity blockade (1-3 days) with an AMPA receptor antagonist increased cell surface (synaptic and extrasynaptic) glutamate receptor 1 (GluR1) and GluR2 but not GluR3, as well as GluR1/2 co-localization on the cell surface and total GluR1 and GluR2 protein levels.
GluR1 Neg (not) Binding (blockade) of associated with glutamate receptor and antagonist
12) Confidence 0.31 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.09 Pain Relevance 0.58
This finding indicates that GluR1 could be recruited to the plasma membrane of spinal cord neurons by persistent noxious inflammation.
GluR1 Binding (recruited) of in spinal cord neurons associated with inflammation and spinal cord
13) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.87 Pain Relevance 1.10
Immunohistochemical analysis of kainate receptor expression using antibodies recognizing glutamate receptor subunits 5, 6, and 7 demonstrates that 28% of unmyelinated axons in normal digital nerve are positively labeled.
glutamate receptor Binding (recognizing) of in nerve associated with glutamate receptor and unmyelinated
14) Confidence 0.26 Published 2006 Journal Neuroscience Section Abstract Doc Link 16330152 Disease Relevance 0.19 Pain Relevance 0.31
g for GluR1, GluR6/7, and NR1 subunits; and 60 ?
GluR1 Binding (/) of
15) Confidence 0.22 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0 Pain Relevance 0
The psychotomimetic analgesic phencyclidine (PCP), which binds to a high affinity site on the neuronal N-methyl-D-aspartate (NMDA)-sensitive glutamate receptor, has previously been found to bind to platelets with high affinity and to specifically delay the onset of epinephrine-stimulated platelet aggregation (Jamieson et al. (1992) Biochem.
glutamate receptor Binding (binds) of in platelet associated with glutamate receptor and analgesic
16) Confidence 0.21 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7981230 Disease Relevance 0 Pain Relevance 0.21
Analgesic interaction between intrathecal midazolam and glutamate receptor antagonists on thermal-induced pain in rats.
glutamate receptor Binding (interaction) of associated with pain, versed, antagonist, glutamate receptor, analgesic and intrathecal
17) Confidence 0.19 Published 1999 Journal Anesthesiology Section Title Doc Link 10443617 Disease Relevance 0.19 Pain Relevance 1.22
The particular EGFP-fusion protein used here was characterized extensively [35],[44]; When expressed in cultured hippocampal neurons, it was shown to localize correctly to postsynaptic structures associated with functional presynaptic sites, colocalize with the AMPA receptor subunit GluR1, and only negligibly affect gross synaptic characteristics [35].
GluR1 Binding (colocalize) of in neurons
18) Confidence 0.18 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0.03
The antibodies used in this experiment bind to specific sites on the GluR1 (Ser831) and GluR2/GluR3 (C terminal) subunits and no cross-reactivity has been reported.
GluR1 Neg (no) Binding (bind) of
19) Confidence 0.16 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0 Pain Relevance 0
However, electrophysiological recordings from GluN2 subunits carrying mutation in the NTD suggest a model in which NTDs of GluN1 and GluN2 heterodimerize [134].
GluN1 Binding (heterodimerize) of
20) Confidence 0.14 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.11

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