INT49552

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Context Info
Confidence 0.55
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 76
Total Number 77
Disease Relevance 36.04
Pain Relevance 44.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
neuronal 8
ventral 6
hepatocytes 6
thalamus 5
cardiac myocytes 4
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 234 100.00 Very High Very High Very High
Paracetamol 185 100.00 Very High Very High Very High
Nicotine 31 100.00 Very High Very High Very High
withdrawal 25 100.00 Very High Very High Very High
cocaine 23 100.00 Very High Very High Very High
anesthesia 23 100.00 Very High Very High Very High
Abeta 12 100.00 Very High Very High Very High
Spinal cord 6 100.00 Very High Very High Very High
narcan 13 99.98 Very High Very High Very High
lidocaine 9 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 519 100.00 Very High Very High Very High
Death 187 100.00 Very High Very High Very High
Diabetes Mellitus 184 100.00 Very High Very High Very High
Toxicity 50 100.00 Very High Very High Very High
Hypoxia 46 100.00 Very High Very High Very High
Necrosis 20 100.00 Very High Very High Very High
Cancer 13 100.00 Very High Very High Very High
Frailty 9 99.92 Very High Very High Very High
Hepatocellular Cancer 3 99.92 Very High Very High Very High
Pneumonia 9 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reducing Na(+) entry with the VSSC blocker, tetrodotoxin (TTX), attenuated apoptotic neuronal death via a reduction in caspase-3 activation.
Negative_regulation (reduction) of Positive_regulation (activation) of caspase-3 in neuronal associated with tetrodotoxin, apoptosis and death
1) Confidence 0.55 Published 2004 Journal Neuroscience Section Abstract Doc Link 15145071 Disease Relevance 1.73 Pain Relevance 0.38
Melatonin-induced neuroprotection was mediated, at least in part, via the inhibition of mitochondria-dependent apoptotic pathway since melatonin caused an up-regulation of the anti-apoptotic protein, bcl-X(L), reduction in anesthesia-induced cytochrome c release into the cytoplasm and a decrease in anesthesia-induced activation of caspase-3, an important step in the activation of DNAses and the formation of the apoptotic bodies.
Negative_regulation (decrease) of Positive_regulation (activation) of caspase-3 associated with anesthesia and apoptosis
2) Confidence 0.55 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16289675 Disease Relevance 0.62 Pain Relevance 0.66
Z-VAD-FMK, a caspase inhibitor, inhibited both the increase in caspase-3-like protease activity and apoptosis in IND-treated RGM1 cells but did not affect caspase-1-like protease activity or mitochondrial cytochrome c release.
Negative_regulation (inhibited) of Positive_regulation (increase) of caspase-3-like associated with apoptosis
3) Confidence 0.50 Published 2000 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 10806417 Disease Relevance 0.82 Pain Relevance 0.07
Bilateral intra-accumbal administration of AM251 (5, 25 and 125 ng/0.5 microl per side) dose-dependently reduced the acquisition and expression of morphine-induced CPP in morphine-sensitized rats, while bilateral intra-accumbal administration of neither saline nor DMSO (0.5 microl/side) had effects on the acquisition and expression of morphine-induced CPP in sensitized rats.
Negative_regulation (reduced) of Positive_regulation (induced) of CPP associated with morphine
4) Confidence 0.46 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18773925 Disease Relevance 0 Pain Relevance 1.55
MK-801 alone (0.1 mg/kg) produced neither a place preference nor a place aversion, but was able to completely block morphine-induced CPP.
Negative_regulation (block) of Positive_regulation (induced) of CPP associated with morphine
5) Confidence 0.44 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7566661 Disease Relevance 0 Pain Relevance 0.56
Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats.
Negative_regulation (suppress) of Positive_regulation (induced) of CPP associated with morphine
6) Confidence 0.43 Published 2005 Journal Exp. Neurol. Section Title Doc Link 15890338 Disease Relevance 0 Pain Relevance 0.43
The expression of morphine-induced CPP was significantly blocked by mirtazapine (10 or 30 mg/kg, i.p.), while chronic treatment with mirtazapine (1 or 10 mg/kg, i.p. once, daily, for six consecutive days) significantly attenuated the acquisition of morphine CPP.
Negative_regulation (blocked) of Positive_regulation (induced) of CPP associated with morphine
7) Confidence 0.43 Published 2008 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 18618337 Disease Relevance 0.07 Pain Relevance 1.06
Injection of CGP38345 (10, 19, 25 and 50 microg/rat) into the ventral tegmental area significantly reduced the expression of CPP induced by morphine.
Negative_regulation (reduced) of Positive_regulation (induced) of CPP in ventral associated with ventral tegmentum and morphine
8) Confidence 0.43 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.53
Western blot analysis showed that AA significantly suppressed 150/145 kDa subunits of alpha-fodrin breakdown products (FBDP) in cortex, striatum, thalamus and hippocampus at 24 and 48 h post-HI, and also 120 kDa subunit of FBDP in all examined regions except for thalamus, which indicated that AA injection inhibited both calpain and caspase-3 activation.
Negative_regulation (inhibited) of Positive_regulation (activation) of caspase-3 in thalamus associated with hippocampus and thalamus
9) Confidence 0.43 Published 2009 Journal Brain Dev. Section Abstract Doc Link 18682317 Disease Relevance 0.58 Pain Relevance 0.36
Lidocaine reduced cytochrome c release and caspase-3 activation in the penumbra at 4 h and diminished DNA fragmentation in the penumbra at 24 h.
Negative_regulation (reduced) of Positive_regulation (activation) of caspase-3 associated with lidocaine
10) Confidence 0.43 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099683 Disease Relevance 0.77 Pain Relevance 1.01
Compared with the untreated hearts, MS1 treatment significantly reduced myocardial infarct size (35.1% +/- 3% vs. 75.5% +/- 5%, p < 0.001), reduced prevalence of apoptotic cells (2.6% +/- 0.5% vs. 12.2% +/- 2.1%, p < 0.001), prevented mitochondrial swelling and cytochrome c release, inhibited downregulation of antiapoptotic protein Bcl-2 expression, and suppressed caspase-3 activation.
Negative_regulation (suppressed) of Positive_regulation (activation) of caspase-3 in apoptotic cells associated with pressure and volume under development, apoptosis and myocardial infarction
11) Confidence 0.42 Published 2007 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 18066098 Disease Relevance 0.57 Pain Relevance 0.08
RT-PCR and Western blotting techniques were used to analyze mRNA and protein expression of HSP72 and HSP90 and cleavage of caspase 3 protein.
Spec (analyze) Negative_regulation (analyze) of Positive_regulation (cleavage) of caspase 3 in cleavage
12) Confidence 0.42 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10859212 Disease Relevance 0.76 Pain Relevance 0.31
Aripiprazole significantly decreased the reinstatement of CPP induced by a priming injection of morphine but had no effect on the expression of morphine-induced CPP or locomotor activity.
Negative_regulation (decreased) of Positive_regulation (induced) of CPP associated with eae and morphine
13) Confidence 0.38 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19353810 Disease Relevance 0.21 Pain Relevance 0.99
The results showed that (1) the morphine-induced CPP was significantly inhibited by 3 or 5 consecutive sessions, but not by single session of 2 Hz PES. (2) A test of spatial leaning and memory ability using the Morris water maze task revealed that 2 Hz PES per se exhibited a promoting, rather than a deteriorating effect on the ability of spatial memory. (3) 2 Hz PES by itself produced a moderate yet significant CPP.
Negative_regulation (inhibited) of Positive_regulation (induced) of CPP associated with morphine
14) Confidence 0.38 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15890338 Disease Relevance 0 Pain Relevance 0.54
Thus, naloxone attenuated the CPP induced by wheel running.
Negative_regulation (attenuated) of Positive_regulation (induced) of CPP associated with narcan
15) Confidence 0.38 Published 2001 Journal Physiol. Behav. Section Abstract Doc Link 11274677 Disease Relevance 0 Pain Relevance 0.51
Furthermore, given the important role of alpha4beta2 (a4b2) nicotinic receptor subtype in the acquisition and maintenance of nicotine dependence, we evaluated and compared the efficacy of varenicline, a partial a4b2 nicotinic receptor agonist (0.5, 1, and 2 mg/kg, subcutaneously (s.c.)), and mecamylamine (0.5, 1, and 2 mg/kg, s.c.), a non-selective nicotinic receptor antagonist, in blocking nicotine-induced CPP as well as reinstatement of nicotine CPP provoked by nicotine and morphine.
Negative_regulation (blocking) of Positive_regulation (induced) of CPP associated with addiction, antagonist, nicotine, agonist and morphine
16) Confidence 0.37 Published 2010 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 20217050 Disease Relevance 0.20 Pain Relevance 1.12
However, pre-testing injections of diazepam blocked the expression of amphetamine-induced CPP, and co-injections of diazepam blocked the formation of amphetamine CPP.
Negative_regulation (blocked) of Positive_regulation (induced) of CPP
17) Confidence 0.37 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10958076 Disease Relevance 0 Pain Relevance 0
In the present experiment, a dose of 4 mg/kg of naloxone completely blocked the CPP induced in females by paced mating.
Negative_regulation (blocked) of Positive_regulation (induced) of CPP associated with narcan
18) Confidence 0.37 Published 2001 Journal Behav. Neurosci. Section Abstract Doc Link 11770067 Disease Relevance 0 Pain Relevance 0.38
Our results demonstrated that mirtazapine attenuates morphine withdrawal and morphine-induced CPP in rats and suggest that mirtazapine may have therapeutic potential in the treatment of opiate dependence.
Negative_regulation (attenuates) of Positive_regulation (induced) of CPP associated with addiction, opiate, withdrawal and morphine
19) Confidence 0.37 Published 2008 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 18618337 Disease Relevance 0.17 Pain Relevance 1.10
Intra-ventral tegmental area administration of the GABA(A) receptor agonist, muscimol (6 microg/rat) reduced the expression of morphine-induced CPP.
Negative_regulation (reduced) of Positive_regulation (induced) of CPP in ventral associated with ventral tegmentum, gaba, agonist and morphine
20) Confidence 0.37 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.41

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