INT49553

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2010
Negated 14
Speculated 2
Reported most in Abstract
Documents 42
Total Number 47
Disease Relevance 17.04
Pain Relevance 23.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
IPN 10
spinal 8
locus coeruleus 5
spinal cord 5
striatum 4
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 159 100.00 Very High Very High Very High
nMDA receptor 158 100.00 Very High Very High Very High
allodynia 99 100.00 Very High Very High Very High
intrathecal 52 100.00 Very High Very High Very High
Dopamine 48 100.00 Very High Very High Very High
IPN 45 100.00 Very High Very High Very High
neuralgia 12 100.00 Very High Very High Very High
electroacupuncture 7 100.00 Very High Very High Very High
Thermal hyperalgesia 4 100.00 Very High Very High Very High
ketamine 116 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 193 100.00 Very High Very High Very High
Hyperalgesia 167 100.00 Very High Very High Very High
Cancer 98 100.00 Very High Very High Very High
Necrosis 12 100.00 Very High Very High Very High
Dermatitis 4 100.00 Very High Very High Very High
Cv Unclassified Under Development 165 99.84 Very High Very High Very High
Diabetes Mellitus 93 99.44 Very High Very High Very High
Post Operative Pain 44 99.28 Very High Very High Very High
Brain Hemorrhage 152 98.52 Very High Very High Very High
Apoptosis 17 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No significant changes in the distribution or relative levels of GFAP mRNA expression, relative levels of GFAP protein or immunoreactivity for GFAP were found in the ipsilateral vestibular nuclei at any post-TTX injection times studied.
Neg (No) Regulation (changes) of Gene_expression (expression) of GFAP mRNA associated with tetrodotoxin
1) Confidence 0.62 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652984 Disease Relevance 0 Pain Relevance 0.40
Moreover, it was found that neuropathic animals with a higher degree of mechanical allodynia had a lower intensity of GFAP expression in lamina II (substantia gelatinosa).
Regulation (intensity) of Gene_expression (expression) of GFAP in lamina associated with substantia gelatinosa, allodynia and neuropathic pain
2) Confidence 0.62 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383423 Disease Relevance 1.00 Pain Relevance 1.08
The effects of the treatments on GFAP expression were studied by immunohistochemical staining in Locus Coeruleus (LC) and Nucleus of the Solitary Tract (NST), two important noradrenergic nuclei.
Regulation (effects) of Gene_expression (expression) of GFAP in Nucleus
3) Confidence 0.61 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123717 Disease Relevance 0.19 Pain Relevance 0.96
These findings suggest that in the IPN, E(2) may directly modulate GFAP-expression through ERbeta-mediated mechanisms.
Regulation (modulate) of Gene_expression (expression) of GFAP in IPN associated with ipn
4) Confidence 0.60 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470889 Disease Relevance 0 Pain Relevance 0.51
We previously demonstrated that in rat, astrocytic glial fibrillary acidic protein- (GFAP) expression in the interpeduncular nucleus (IPN) was responsive to testosterone and in females the intensity of GFAP-immunoreactivity (IR) followed the periodic hormonal changes of the estrous cycle.
Regulation (responsive) of Gene_expression (expression) of glial fibrillary acidic protein in interpeduncular nucleus associated with ipn
5) Confidence 0.53 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470889 Disease Relevance 0 Pain Relevance 0.30
These investigators (O’Callaghan and Miller 1993) carried out extensive studies to evaluate the effects of MDMA administration on GFAP expression in rat brain.
Regulation (effects) of Gene_expression (expression) of GFAP in brain
6) Confidence 0.49 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1705495 Disease Relevance 0.23 Pain Relevance 0.15
GFAP mRNA expression and immunoreactivity in the cochlear nucleus was qualitatively stronger than in the ipsilateral vestibular nuclei.
Regulation (stronger) of Gene_expression (expression) of GFAP mRNA in cochlear nucleus
7) Confidence 0.45 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652984 Disease Relevance 0 Pain Relevance 0.33
Since cyclic fluctuations of synaptic numbers in the female have been described only for the endocrine hypothalamus, decrease of immunoreactive GFAP in the IPN during estrus may reflect a down-regulation of GFAP synthesis.
Regulation (down-regulation) of Gene_expression (synthesis) of GFAP in hypothalamus associated with ipn
8) Confidence 0.45 Published 2000 Journal Brain Res. Section Abstract Doc Link 10799667 Disease Relevance 0 Pain Relevance 0.17
The expression of glial fibrillary acidic protein (GFAP) in PBN of ipsilateral and contralateral sides was up-regulated 4 h after occlusal changes in molars, reached peak levels at 24 h, and was then gradually down-regulated.
Regulation (reached) of Gene_expression (expression) of GFAP in molars
9) Confidence 0.45 Published 2007 Journal Cell Tissue Res. Section Abstract Doc Link 17443351 Disease Relevance 0.37 Pain Relevance 0.26
The expression of glial fibrillary acidic protein (GFAP) in PBN of ipsilateral and contralateral sides was up-regulated 4 h after occlusal changes in molars, reached peak levels at 24 h, and was then gradually down-regulated.
Regulation (reached) of Gene_expression (expression) of glial fibrillary acidic protein in molars
10) Confidence 0.45 Published 2007 Journal Cell Tissue Res. Section Abstract Doc Link 17443351 Disease Relevance 0.37 Pain Relevance 0.26
The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid).
Spec (whether) Regulation (affected) of Spec (whether) Gene_expression (expressions) of GFAP associated with fluoxetine
11) Confidence 0.45 Published 2008 Journal Schizophr. Res. Section Abstract Doc Link 18585900 Disease Relevance 0.27 Pain Relevance 0.22
OBJECTIVE: To observe the effect of electroacupuncture (EA) on the expression of spinal glial fibrillary acidic protein (GFAP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in chronic constriction injury (CCI) rats.
Regulation (effect) of Gene_expression (expression) of GFAP in spinal associated with necrosis, cancer, eae, injury and electroacupuncture
12) Confidence 0.45 Published 2010 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 20458900 Disease Relevance 0.52 Pain Relevance 0.21
OBJECTIVE: To observe the effect of electroacupuncture (EA) on the expression of spinal glial fibrillary acidic protein (GFAP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in chronic constriction injury (CCI) rats.
Regulation (effect) of Gene_expression (expression) of glial fibrillary acidic protein in spinal associated with necrosis, cancer, eae, injury and electroacupuncture
13) Confidence 0.45 Published 2010 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 20458900 Disease Relevance 0.52 Pain Relevance 0.21
No significant changes in the distribution or relative levels of GFAP mRNA expression, relative levels of GFAP protein or immunoreactivity for GFAP were found in the ipsilateral vestibular nuclei at any post-TTX injection times studied.
Neg (No) Regulation (changes) of Gene_expression (expression) of GFAP associated with tetrodotoxin
14) Confidence 0.44 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652984 Disease Relevance 0 Pain Relevance 0.41
Using quantitative Western blot analysis, our report showed that intrathecal ketamine down-regulated glial fibrillary acidic protein expression, suggesting inhibition of SNL-induced astrocytic activation, which wasn't influenced by intraperitoneal administration.
Regulation (regulated) of Gene_expression (expression) of glial fibrillary acidic protein associated with ketamine, spinal nerve ligature and intrathecal
15) Confidence 0.44 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383087 Disease Relevance 0.54 Pain Relevance 2.05
We previously demonstrated that in rat, astrocytic glial fibrillary acidic protein- (GFAP) expression in the interpeduncular nucleus (IPN) was responsive to testosterone and in females the intensity of GFAP-immunoreactivity (IR) followed the periodic hormonal changes of the estrous cycle.
Regulation (responsive) of Gene_expression (expression) of GFAP in interpeduncular nucleus associated with ipn
16) Confidence 0.44 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470889 Disease Relevance 0 Pain Relevance 0.30
These results indicate that E(2), in the absence of other ovarian hormones, modulates GFAP-expression within select IPN subnuclei and that these affects are dependent on position along the AP axis.
Regulation (modulates) of Gene_expression (expression) of GFAP in IPN associated with ipn
17) Confidence 0.44 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470889 Disease Relevance 0 Pain Relevance 0.63
The expression of retinal GFAP is unaltered in SHR or WKY rats
Regulation (unaltered) of Gene_expression (expression) of GFAP
18) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.16 Pain Relevance 0
[Effect of electroacupuncture on the expression of spinal glial fibrillary acidic protein, tumor necrosis factor-alpha and interleukin-1beta in chronic neuropathic pain rats].
Regulation ([Effect) of Gene_expression (expression) of glial fibrillary acidic protein in spinal associated with necrosis, neuralgia, cancer, neuropathic pain and electroacupuncture
19) Confidence 0.39 Published 2010 Journal Zhen Ci Yan Jiu Section Title Doc Link 20458900 Disease Relevance 0.30 Pain Relevance 0.54
In the present experiment, we injected LAA and observed that SNL-induced mechanical allodynia was suppressed and GFAP expression was down regulated.
Regulation (regulated) of Gene_expression (expression) of GFAP associated with allodynia and spinal nerve ligature
20) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 1.25 Pain Relevance 1.60

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