INT49555

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 11.51
Pain Relevance 10.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
masseter 6
CSF 4
hippocampus 3
spinal 3
brainstem 2
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 29 100.00 Very High Very High Very High
Morphine 28 100.00 Very High Very High Very High
nMDA receptor 27 100.00 Very High Very High Very High
Inflammation 209 99.98 Very High Very High Very High
medulla 13 99.84 Very High Very High Very High
Enkephalin 3 99.68 Very High Very High Very High
glial activation 21 99.12 Very High Very High Very High
tetrodotoxin 11 98.80 Very High Very High Very High
Central grey 14 98.40 Very High Very High Very High
antagonist 11 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ocular Hypertension 150 100.00 Very High Very High Very High
Aids-related Complex 1 100.00 Very High Very High Very High
INFLAMMATION 232 99.98 Very High Very High Very High
Convulsion 6 99.78 Very High Very High Very High
Urological Neuroanatomy 15 98.40 Very High Very High Very High
Normal Pressure Hydrocephalus 2 98.20 Very High Very High Very High
Hypothermia 1 95.68 Very High Very High Very High
Hyperalgesia 233 95.56 Very High Very High Very High
Hydrocephalus 124 95.36 Very High Very High Very High
Cv General 4 Under Development 2 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate the role of activity, we carried out four experiments: (1) tetrodotoxin (TTX) was injected into the EC to mimic the decreases in afferent drive that occur after lesion; (2) TTX was injected into the EC or hippocampus before producing electrolytic lesions to block any abnormal activity induced during lesion production; (3) the EC was destroyed by aspiration, thus creating a lesion comparable in size to the electrolytic lesion, without passing direct current; (4) seizures were elicited by stimulating the EC of anesthetized rats, to examine whether electrographic seizures alone can induce the same type of increases in GFAP mRNA as lesions.
Positive_regulation (induce) of Positive_regulation (increases) of GFAP mRNA in hippocampus associated with tetrodotoxin, convulsion and hippocampus
1) Confidence 0.69 Published 1993 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 8328294 Disease Relevance 0.26 Pain Relevance 0.56
These observations are further supported by Western blot analysis that shows a selective enhancement of NMDA receptor phosphorylation and GFAP upregulation in the Vi/Vc transition zone after masseter inflammation.
Positive_regulation (enhancement) of Positive_regulation (upregulation) of GFAP in masseter associated with inflammation and nmda receptor
2) Confidence 0.52 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.01 Pain Relevance 0.75
Yohimbine was found to efficiently prevent morphine-induced GFAP upregulation.
Positive_regulation (morphine-induced) of Positive_regulation (upregulation) of GFAP associated with morphine
3) Confidence 0.50 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123717 Disease Relevance 0.22 Pain Relevance 1.26
This anatomically specific pattern of increased GFAP suggests activation of astrocytes by select neural pathways, which likely include afferents of both spinal and nucleus of the solitary tract (NTS) origin.
Positive_regulation (activation) of Positive_regulation (increased) of GFAP in spinal
4) Confidence 0.50 Published 2010 Journal Neuroscience Section Abstract Doc Link 20109535 Disease Relevance 1.16 Pain Relevance 0.85
Glial fibrillary acidic protein (Gfap) and activity-regulated cytoskeleton-associated protein (Arc) mRNA were upregulated, while growth associated protein (Gap43), clathrin heavy chain (Cltc), alpha-tubulin, Tau, and stathmin were downregulated.
Positive_regulation (upregulated) of Positive_regulation (upregulated) of Gfap associated with aids-related complex
5) Confidence 0.49 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.10 Pain Relevance 0.40
Pretreatment with yohimbine (2 mg kg(-1), i.p., 30 min before each morphine injection) provided protection against morphine-induced GFAP upregulation.
Positive_regulation (morphine-induced) of Positive_regulation (upregulation) of GFAP associated with morphine
6) Confidence 0.49 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15936527 Disease Relevance 0.09 Pain Relevance 0.86
A similar increase in GFAP immunoreactivity can be induced by intraocular injections of tetrodotoxin, demonstrating that a reversible manipulation of optic nerve electrical activity is sufficient to regulate LGN astrocytes.
Positive_regulation (induced) of Positive_regulation (increase) of GFAP in LGN associated with tetrodotoxin
7) Confidence 0.47 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874503 Disease Relevance 0 Pain Relevance 0.14
TMT led to marked elevations in GFAP levels, a response that was affected by Ta.
Positive_regulation (led) of Positive_regulation (elevations) of GFAP
8) Confidence 0.46 Published 1995 Journal Neurotoxicology Section Abstract Doc Link 7566691 Disease Relevance 0.17 Pain Relevance 0.29
This study evaluates whether the rapid transient increases in glial fibrillary acidic protein (GFAP) mRNA in the hippocampus after electrolytic lesions of the entorhinal cortex (EC) are triggered by lesion-induced changes in hippocampal neuronal activity (either the decreases that result from loss of afferent drive or transient increases that occur during lesion production).
Spec (whether) Positive_regulation (triggered) of in cortex Spec (whether) Positive_regulation (increases) of GFAP in hippocampus associated with hippocampus
9) Confidence 0.45 Published 1993 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 8328294 Disease Relevance 0 Pain Relevance 0.31
Clinically, increased levels of GFAP have been found in the CSF of patients with normal pressure hydrocephalus, and in patients who developed secondary hydrocephalus due to subarachnoid hemorrhage [23-26], and the possibility of using GFAP levels as a diagnostic tool for hydrocephalus is currently being explored [27,28].
Positive_regulation (increased) of Positive_regulation (levels) of GFAP in CSF associated with normal pressure hydrocephalus, cv general 4 under development, hydrocephalus and cva
10) Confidence 0.45 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.89 Pain Relevance 0.11
Clinically, increased levels of GFAP have been found in the CSF of patients with normal pressure hydrocephalus, and in patients who developed secondary hydrocephalus due to subarachnoid hemorrhage [23-26], and the possibility of using GFAP levels as a diagnostic tool for hydrocephalus is currently being explored [27,28].
Positive_regulation (levels) of Positive_regulation (increased) of GFAP in CSF associated with normal pressure hydrocephalus, cv general 4 under development, hydrocephalus and cva
11) Confidence 0.45 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.89 Pain Relevance 0.11
Yohimbine prevents morphine-induced changes of glial fibrillary acidic protein in brainstem and alpha2-adrenoceptor gene expression in hippocampus.
Positive_regulation (morphine-induced) of Positive_regulation (changes) of fibrillary acidic protein in brainstem associated with medulla, hippocampus and morphine
12) Confidence 0.44 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17123717 Disease Relevance 0.16 Pain Relevance 0.87
These observations suggest that IOP elevation is an important factor for increasing the levels of AQP4 and GFAP, which could promote glial activation at the optic nerve.
Positive_regulation (factor) of Positive_regulation (increasing) of GFAP in optic nerve associated with ocular hypertension and glial activation
13) Confidence 0.42 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.24 Pain Relevance 0.05
Western blot data showed that masseter inflammation induced an enhanced NMDA receptor phosphorylation and upregulation of GFAP in both Vi/Vc and Vc zones, while cutaneous inflammation only induced similar effects in the caudal Vc.
Positive_regulation (induced) of Positive_regulation (upregulation) of GFAP in masseter associated with inflammation and nmda receptor
14) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.39 Pain Relevance 1.12
Western blot data showed that masseter inflammation induced an enhanced NMDA receptor phosphorylation and upregulation of GFAP in both Vi/Vc and Vc zones, while cutaneous inflammation only induced similar effects in the caudal Vc.
Positive_regulation (enhanced) of Positive_regulation (upregulation) of GFAP in masseter associated with inflammation and nmda receptor
15) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.38 Pain Relevance 1.12
ET-1 injection also resulted in an increase in GFAP (Figure 4A, 380±100%, p<0.005) and similarly, elevation of IOP increased GFAP expression in all screened rats (133±10%, p<0.005, Figure 4B,C, n=6).
Positive_regulation (increased) of Positive_regulation (increase) of GFAP associated with ocular hypertension
16) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.97 Pain Relevance 0
Therefore after the LPS insult the increase in astrogliosis was due to an increase activation of GFAP in existing cells.
Positive_regulation (increase) of Positive_regulation (activation) of GFAP
17) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864748 Disease Relevance 0.10 Pain Relevance 0.05
This anatomically specific pattern of increased GFAP suggests activation of astrocytes by select neural pathways, which likely include afferents of both spinal and nucleus of the solitary tract (NTS) origin.
Positive_regulation (activation) of in nucleus Positive_regulation (increased) of GFAP in spinal
18) Confidence 0.17 Published 2010 Journal Neuroscience Section Abstract Doc Link 20109535 Disease Relevance 1.16 Pain Relevance 0.85
The abnormally myelinated fibers in the marbled state were stained with both Kluver-Barrera and Holzer stainings; however, they were partly immunopositive for MBP and completely immunonegative for GFAP, CaBD, MEnk, PV, SuP and SP, although some of the neurons and/or fibers showed immunoreactivities for those calcium-binding proteins and/or neurotransmitters.
Positive_regulation (immunopositive) of Positive_regulation (immunonegative) of GFAP in neurons associated with neurotransmitter and enkephalin
19) Confidence 0.09 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 10483783 Disease Relevance 0.32 Pain Relevance 0.58

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