INT49556

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 11
Total Number 20
Disease Relevance 29.44
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NOLC1) mitosis (NOLC1) nucleolus (NOLC1)
nucleus (NOLC1) cell cycle (NOLC1) DNA binding (NOLC1)
Anatomy Link Frequency
astrocytes 3
microglia 3
blood 1
macrophages 1
gray matters 1
NOLC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurobehavioral 70 91.92 High High
Inflammation 45 91.52 High High
cytokine 111 90.48 High High
Opioid 7 89.08 High High
chemokine 70 80.84 Quite High
methadone 15 50.00 Quite Low
Central nervous system 30 42.24 Quite Low
Inflammatory response 20 30.40 Quite Low
fibrosis 39 5.00 Very Low Very Low Very Low
glial activation 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 2579 100.00 Very High Very High Very High
Infection 666 100.00 Very High Very High Very High
Injury 112 99.72 Very High Very High Very High
Dementia 30 99.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 898 98.52 Very High Very High Very High
Sprains And Strains 43 98.00 Very High Very High Very High
Targeted Disruption 120 94.68 High High
Cognitive Disorder 21 92.32 High High
INFLAMMATION 64 91.52 High High
Death 57 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these subjects, 96.7% stated they had HCV infection (data not shown).
Gene_expression (infection) of HCV associated with hepatitis c virus infection and infection
1) Confidence 0.49 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.14 Pain Relevance 0
We also found that history of tattooing, a practice also common to incarcerated populations, was an independent risk factor for HCV infection.18,27–29 In the abovementioned study of prisoners in Zanjan, tattooing was also associated with HCV positivity among prisoners.18
Gene_expression (positivity) of HCV associated with hepatitis c virus infection and infection
2) Confidence 0.49 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.12 Pain Relevance 0.08
Although years of drug use was not associated with HCV infection, time engaging in injection achieved over 95% prevalence after 5 years.
Gene_expression (infection) of HCV associated with hepatitis c virus infection and infection
3) Confidence 0.49 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.23 Pain Relevance 0
Moreover, there was a borderline association between HCV infection and younger age of first injection.
Gene_expression (infection) of HCV associated with hepatitis c virus infection and infection
4) Confidence 0.49 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.37 Pain Relevance 0
Entering all variables associated with HCV infection at the p???
Gene_expression (infection) of HCV associated with hepatitis c virus infection and infection
5) Confidence 0.49 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.38 Pain Relevance 0
There was a significant association between age and HCV (p?
Gene_expression (age) of HCV associated with hepatitis c virus infection
6) Confidence 0.49 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.11 Pain Relevance 0
We also found that history of tattooing, a practice also common to incarcerated populations, was an independent risk factor for HCV infection.18,27–29 In the abovementioned study of prisoners in Zanjan, tattooing was also associated with HCV positivity among prisoners.18
Gene_expression (infection.18,27) of HCV associated with hepatitis c virus infection and infection
7) Confidence 0.49 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.15 Pain Relevance 0.09
Herein, expression of HCV proteins, core and NS3, were immunodetected in the cytoplasm of primary human astrocytes and microglia infected with HCVcc.
Gene_expression (expression) of HCV in astrocytes associated with hepatitis c virus infection
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.33 Pain Relevance 0
Recently, HCV proteins including core, non-structural protein 3 (NS3) and NS5A were detected in macrophages/microglia and astrocytes but not in neurons nor oligodendrocytes of patients with HIV/HCV co-infection [9], [18].
Neg (not) Gene_expression (detected) of HCV in astrocytes associated with acquired immune deficiency syndrome or hiv infection, hepatitis c virus infection and infection
9) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 2.07 Pain Relevance 0.12
The strain difference and other co-morbidities such as intravenous drug use might influence the infection and production of HCV in human brain, as demonstrated for HIV infection [56].
Gene_expression (production) of HCV in brain associated with acquired immune deficiency syndrome or hiv infection, hepatitis c virus infection, sprains and strains and infection
10) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 2.08 Pain Relevance 0.03
HCV-encoded RNA as well as HCV core and non-structural 3 (NS3) proteins were detectable in human microglia and astrocytes infected with HCV.
Gene_expression (detectable) of HCV in astrocytes associated with hepatitis c virus infection
11) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943470 Disease Relevance 2.40 Pain Relevance 0.18
The most abundantly expressed HCV protein, core, is released and soluble in blood as a part of HCV morphogenesis [27] and serum levels of HCV core protein ranges from pg/ml to ng/ml [28].
Gene_expression (expressed) of HCV protein in blood associated with hepatitis c virus infection
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.98 Pain Relevance 0.09
Given HCV core protein has been detected in white and gray matters [9], its cytotoxic effects on HFAs and HFNs were investigated.
Gene_expression (detected) of HCV in gray matters associated with hepatitis c virus infection
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.02 Pain Relevance 0.07
Anti-HCV drugs can produce adverse outcomes in coinfected patients receiving ART.
Gene_expression (produce) of HCV associated with hepatitis c virus infection
14) Confidence 0.02 Published 2007 Journal Journal of Viral Hepatitis Section Body Doc Link PMC1974798 Disease Relevance 0.53 Pain Relevance 0
HCV antibodies were detected in 84.2% of the sample and HCV RNA in 66.1% of the sample including 75.9% amongst those who were anti-HCV positive and 16.6% amongst those who were anti-HCV negative.
Neg (negative) Gene_expression (negative) of HCV
15) Confidence 0.01 Published 1995 Journal N. Z. Med. J. Section Body Doc Link 7566775 Disease Relevance 0.14 Pain Relevance 0
Herein, expression of HCV proteins, core and NS3, were immunodetected in the cytoplasm of primary human astrocytes and microglia infected with HCVcc.
Gene_expression (expression) of HCV in microglia associated with hepatitis c virus infection
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.33 Pain Relevance 0
Recently, HCV proteins including core, non-structural protein 3 (NS3) and NS5A were detected in macrophages/microglia and astrocytes but not in neurons nor oligodendrocytes of patients with HIV/HCV co-infection [9], [18].
Neg (not) Gene_expression (detected) of HCV in microglia associated with acquired immune deficiency syndrome or hiv infection, hepatitis c virus infection and infection
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 2.07 Pain Relevance 0.12
Recently, HCV proteins including core, non-structural protein 3 (NS3) and NS5A were detected in macrophages/microglia and astrocytes but not in neurons nor oligodendrocytes of patients with HIV/HCV co-infection [9], [18].
Neg (not) Gene_expression (detected) of HCV in macrophages associated with acquired immune deficiency syndrome or hiv infection, hepatitis c virus infection and infection
18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 2.07 Pain Relevance 0.12
HCV-encoded RNA as well as HCV core and non-structural 3 (NS3) proteins were detectable in human microglia and astrocytes infected with HCV.
Gene_expression (detectable) of HCV in microglia associated with hepatitis c virus infection
19) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943470 Disease Relevance 2.40 Pain Relevance 0.18
It is not certain when during pregnancy and delivery HCV transmission occurs, however, one study suggested that 1/3 to 1/2 of infants acquiring HCV from their mothers were infected in utero.75 Although HCV RNA is detectable in maternal colostrum, viral transmission via breastfeeding has not been well documented.
Gene_expression (detectable) of HCV in colostrum associated with hepatitis c virus infection
20) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731021 Disease Relevance 1.50 Pain Relevance 0

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