INT49563

Context Info Confidence 0.57 First Reported 1995 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.79 Pain Relevance 1.61

plasma membrane (PTGDR) signal transducer activity (PTGDR)

Anatomy Link Frequency striatum 1 PTGDR (Homo sapiens)

Pain Link Frequency Relevance Heat Dopamine 17 99.46 Morphine 3 99.06 aspirin 3 91.84 cINOD 4 90.96 agonist 16 90.56 antagonist 9 89.64 Opioid 4 89.20 Serotonin 3 83.60 opioid receptor 1 78.88 antidepressant 19 75.76

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 42 98.96 Disease 4 95.32 Parkinson's Disease 2 94.24 Anxiety Disorder 89 91.12 Rhinitis 1 83.40 Tics 1 77.92 Diabetes Mellitus 5 60.48 Hemorrhage 1 55.60 Impaired Glucose Tolerance 1 51.00 Dyslipidemia / Combined Dyslipidemia 7 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although laropiprant is a potent inhibitor of prostaglandin D2-receptor-1, it does not eliminate flushing in all patients.

Negative_regulation (inhibitor) of prostaglandin D2-receptor associated with increased venous pressure under development

1) Confidence 0.57 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.79 Pain Relevance 0.22

The results show that both naltrexone and morphine [0.1-1.0 mg/kg; intramuscular injection (IM)] inhibited D2 receptor stimulated contralateral rotational behavior and hand use induced by administration of quinpirole (LY 171555; 0.01 mg/kg, IM) in a dose-related way.

Negative_regulation (inhibited) of D2 receptor associated with morphine

2) Confidence 0.35 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568632 Disease Relevance 0.49 Pain Relevance 0.87

This might reflect a compensatory mechanism resulting from higher synaptic concentrations of dopamine in the striatum, leading to an elevation in the dopamine transporter and to a down-regulation of the D2 receptor.

Negative_regulation (regulation) of D2 receptor in striatum associated with dopamine

3) Confidence 0.03 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.51 Pain Relevance 0.52

General Comments

This test has worked.