INT49563

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.79
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGDR) signal transducer activity (PTGDR)
Anatomy Link Frequency
striatum 1
PTGDR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 17 99.46 Very High Very High Very High
Morphine 3 99.06 Very High Very High Very High
aspirin 3 91.84 High High
cINOD 4 90.96 High High
agonist 16 90.56 High High
antagonist 9 89.64 High High
Opioid 4 89.20 High High
Serotonin 3 83.60 Quite High
opioid receptor 1 78.88 Quite High
antidepressant 19 75.76 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 42 98.96 Very High Very High Very High
Disease 4 95.32 Very High Very High Very High
Parkinson's Disease 2 94.24 High High
Anxiety Disorder 89 91.12 High High
Rhinitis 1 83.40 Quite High
Tics 1 77.92 Quite High
Diabetes Mellitus 5 60.48 Quite High
Hemorrhage 1 55.60 Quite High
Impaired Glucose Tolerance 1 51.00 Quite High
Dyslipidemia /

Combined Dyslipidemia

7 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although laropiprant is a potent inhibitor of prostaglandin D2-receptor-1, it does not eliminate flushing in all patients.
Negative_regulation (inhibitor) of prostaglandin D2-receptor associated with increased venous pressure under development
1) Confidence 0.57 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.79 Pain Relevance 0.22
The results show that both naltrexone and morphine [0.1-1.0 mg/kg; intramuscular injection (IM)] inhibited D2 receptor stimulated contralateral rotational behavior and hand use induced by administration of quinpirole (LY 171555; 0.01 mg/kg, IM) in a dose-related way.
Negative_regulation (inhibited) of D2 receptor associated with morphine
2) Confidence 0.35 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568632 Disease Relevance 0.49 Pain Relevance 0.87
This might reflect a compensatory mechanism resulting from higher synaptic concentrations of dopamine in the striatum, leading to an elevation in the dopamine transporter and to a down-regulation of the D2 receptor.
Negative_regulation (regulation) of D2 receptor in striatum associated with dopamine
3) Confidence 0.03 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.51 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox