INT49564

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 3.28
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGDR) signal transducer activity (PTGDR)
Anatomy Link Frequency
blood 1
primary motor cortex 1
cortex 1
PTGDR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 9 99.78 Very High Very High Very High
Opioid 13 99.68 Very High Very High Very High
agonist 2 99.60 Very High Very High Very High
antagonist 9 99.14 Very High Very High Very High
imagery 33 97.52 Very High Very High Very High
narcan 3 94.80 High High
Pain 131 92.84 High High
headache 8 91.84 High High
Dopamine 22 91.08 High High
opioid receptor 3 87.52 High High
Disease Link Frequency Relevance Heat
Disease Progression 1 99.92 Very High Very High Very High
Disease 22 99.24 Very High Very High Very High
Increased Venous Pressure Under Development 53 99.18 Very High Very High Very High
Parkinson's Disease 4 98.04 Very High Very High Very High
Dementia 3 94.96 High High
Pain 161 92.84 High High
Primary Headache Disorders 4 91.84 High High
Hyperalgesia 4 90.52 High High
Headache 7 83.88 Quite High
Epilepsy 5 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The efficacy of flunarizine may be associated with the activation of D2 receptor and the added treatment with melatonin may hasten the good effect similar to that seen in our patient.
Positive_regulation (activation) of D2 receptor
1) Confidence 0.70 Published 2005 Journal Neurol. Neurochir. Pol. Section Abstract Doc Link 15735995 Disease Relevance 0.61 Pain Relevance 0.61
Increase in D2 receptor density as assessed by the uptake of YM 09151-2 was observed in cases with reduced FDOPA uptake, which may correspond to the state of supersensitivity of the D2 receptors.
Positive_regulation (Increase) of D2 receptor
2) Confidence 0.70 Published 1995 Journal No To Hattatsu Section Abstract Doc Link 7727157 Disease Relevance 0.65 Pain Relevance 0.17
The readiest explanation for this pattern of results is that D2 receptor activation has a consolidation-enhancing effect on tDCS-induced changes of excitability in the human cortex.
Positive_regulation (activation) of D2 receptor in cortex
3) Confidence 0.63 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553629 Disease Relevance 0 Pain Relevance 0.13
Prior studies have shown that enhancement of D2 receptor activity by pergolide consolidates tDCS-generated excitability diminution for up to 24 hours and that cathodal stimulation of the primary motor cortex diminishes experimentally induced pain sensation and reduces the N2-P2 amplitude of laser-evoked potentials immediately poststimulation.
Positive_regulation (enhancement) of D2 receptor in primary motor cortex associated with pain
4) Confidence 0.47 Published 2008 Journal J Pain Symptom Manage Section Abstract Doc Link 18358692 Disease Relevance 0.21 Pain Relevance 0.21
D1 activation alone in the presence of D2 receptor blocking induced by co-administration of sulpiride and pergolide did not re-establish the excitability changes induced by tDCS.
Positive_regulation (induced) of D2 receptor
5) Confidence 0.45 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553629 Disease Relevance 0 Pain Relevance 0.09
Niacin-induced flushing has been demonstrated to be mediated by activation of prostaglandin-2 (PGD2) subtype receptor-1 (DP1 receptors) in vascular smooth muscle cells of dermal arterioles resulting in dilation, increased blood flow and subsequently flushing.
Positive_regulation (activation) of DP1 in blood associated with increased venous pressure under development
6) Confidence 0.45 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857616 Disease Relevance 0.51 Pain Relevance 0.04
From this study it is concluded that in a non-human primate model of PD, alteration of opioid tonus leads to modulation of D2 receptor but not D1 receptor controlled motor behavior.
Positive_regulation (modulation) of D2 receptor associated with disease and opioid
7) Confidence 0.41 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568632 Disease Relevance 0.43 Pain Relevance 0.82
Therefore, in the present study the effects of the opioid antagonist naltrexone and agonist morphine on D1 and D2 receptor induced stimulation of motor behavior in the unilateral MPTP monkey model (n = 5) of PD were investigated.
Spec (investigated) Positive_regulation (induced) of D2 receptor associated with parkinson's disease, antagonist, agonist, disease, opioid and morphine
8) Confidence 0.41 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568632 Disease Relevance 0.46 Pain Relevance 0.73
Opioids may produce changes in the BG including increases in D2 receptor binding [88].
Positive_regulation (increases) of D2 receptor associated with opioid
9) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2883978 Disease Relevance 0.42 Pain Relevance 1.82

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