INT49566

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 5.74
Pain Relevance 5.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LMOD1) cytoskeleton (LMOD1) cytoplasm (LMOD1)
Anatomy Link Frequency
PFC 1
LMOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopamine receptor 58 100.00 Very High Very High Very High
Pain 21 99.98 Very High Very High Very High
Morphine 3 99.92 Very High Very High Very High
Dopamine 820 99.86 Very High Very High Very High
agonist 310 99.74 Very High Very High Very High
antagonist 218 99.28 Very High Very High Very High
Opioid 19 99.06 Very High Very High Very High
Catechol-O-methyltransferase 34 97.24 Very High Very High Very High
Kinase C 1 94.64 High High
opioid receptor 26 87.80 High High
Disease Link Frequency Relevance Heat
Fever 11 99.66 Very High Very High Very High
Dyskinesias 96 98.16 Very High Very High Very High
Parkinson's Disease 88 98.04 Very High Very High Very High
Muscle Hypotonia 12 97.84 Very High Very High Very High
Disease 54 96.88 Very High Very High Very High
Hyperkinesis 14 96.84 Very High Very High Very High
Bordatella Infection 1 96.76 Very High Very High Very High
Fecal Incontinence 1 95.80 Very High Very High Very High
Incontinence 4 93.92 High High
Schizophrenia 8 89.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the early phase, the response of FA at 33 ms was significantly higher during painful than non-painful stimulation for both D1 and D5.
Positive_regulation (stimulation) of D1 associated with pain
1) Confidence 0.61 Published 2004 Journal Brain Topogr Section Abstract Doc Link 15754874 Disease Relevance 0.07 Pain Relevance 0.79
The considered impaired dopamine/D1 interaction is confirmed by treatment efficacy of very low doses of levodopa, because low dosage treatment increases the D1-interacting nanomolar dopamine levels and restores the normal tone inhibition.
Positive_regulation (increases) of D1 associated with dopamine
2) Confidence 0.56 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 1.03 Pain Relevance 0.34
According to our hypothesis, the excessive stimulation of D1 receptors facilitates the tone inhibition leading to muscular hypotonia and reduction of tonic antagonist resistance.
Positive_regulation (stimulation) of D1 associated with muscle hypotonia and antagonist
3) Confidence 0.43 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.87 Pain Relevance 0.45
The planning of experimental designs for investigation of differential motor effects associated with either D1 or D2 stimulation requires hypotheses about the specific motor effects separately induced by selective stimulation of either D1 or D2 receptors.
Positive_regulation (stimulation) of D1
4) Confidence 0.43 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.19 Pain Relevance 0.10
The planning of experimental designs for investigation of differential motor effects associated with either D1 or D2 stimulation requires hypotheses about the specific motor effects separately induced by selective stimulation of either D1 or D2 receptors.
Positive_regulation (stimulation) of D1
5) Confidence 0.40 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.13 Pain Relevance 0.10
The hypothesis of an integrative system that influences D1-mediated tone inhibition and D2-accelerated contraction is also applicable for explanation of disorders with excessive involuntary movements.
Positive_regulation (influences) of D1 associated with dyskinesias
6) Confidence 0.40 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 1.08 Pain Relevance 0.27
According to our hypothesis as movement starts, dopamine first saturates D1 and then D2 receptors.
Positive_regulation (saturates) of D1 associated with dopamine
7) Confidence 0.40 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0 Pain Relevance 0.28
Enhancement of D2 and, to a lesser degree, D1 receptors by pergolide consolidated tDCS-generated excitability diminution until the morning after stimulation.
Positive_regulation (Enhancement) of D1
8) Confidence 0.35 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553629 Disease Relevance 0 Pain Relevance 0.08
D1 activation alone in the presence of D2 receptor blocking induced by co-administration of sulpiride and pergolide did not re-establish the excitability changes induced by tDCS.
Positive_regulation (activation) of D1
9) Confidence 0.33 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553629 Disease Relevance 0 Pain Relevance 0.09
Therefore, in the present study the effects of the opioid antagonist naltrexone and agonist morphine on D1 and D2 receptor induced stimulation of motor behavior in the unilateral MPTP monkey model (n = 5) of PD were investigated.
Spec (investigated) Positive_regulation (induced) of D1 associated with parkinson's disease, antagonist, agonist, disease, opioid and morphine
10) Confidence 0.31 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568632 Disease Relevance 0.46 Pain Relevance 0.73
Arnsten and Dudley [66] have shown that the PFC-enhancing effects of methylphenidate are prevented by blockade of either NE alpha-2 or DAD1 receptors, suggesting that stimulants facilitate endogenous stimulation of D1 and alpha-2A receptors in the PFC.
Positive_regulation (stimulation) of D1 in PFC
11) Confidence 0.12 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.15 Pain Relevance 0.35
The Met allele associated with low-activity COMT decreases phasic and increases tonic DA transmission sub-cortically, and increases DA concentrations cortically: this is associated with increased D1 and decreased D2 transmission in the PFC [26].
Positive_regulation (increased) of D1 associated with catechol-o-methyltransferase and dopamine
12) Confidence 0.07 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.29 Pain Relevance 0.61
Furthermore, calcium signaling by D1-D2 dopamine receptor co-activation was abolished following treatment with a phospholipase C inhibitor but not with pertussis toxin or inhibitors of protein kinase A or protein kinase C, indicating coupling to the G?
Positive_regulation (activation) of D1 associated with kinase c, bordatella infection and dopamine receptor
13) Confidence 0.05 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0.10 Pain Relevance 0.65
MIF was elevated on D1, MCP-1 on D2, and IP-10 on D5 (p < 0.01) (Figure 1).
Positive_regulation (elevated) of D1
14) Confidence 0.05 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC3013083 Disease Relevance 0.13 Pain Relevance 0.20
This information, coupled with the D1-mediated increase in NSF mRNA or D2-mediated increase in NSF protein found in this study, suggest that the DAergic inhibition of LH release involves hypothalamic NSF-dependent mechanisms.
Positive_regulation (increase) of D1
15) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924890 Disease Relevance 0.15 Pain Relevance 0.46
This information, coupled with the D1-mediated increase in NSF mRNA or D2-mediated increase in NSF protein found in this study, suggest that the DAergic inhibition of LH release involves hypothalamic NSF-dependent mechanisms.
Positive_regulation (increase) of D1
16) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924890 Disease Relevance 0.15 Pain Relevance 0.42
All these signs are usually accompanied by fever, which tends to reach its highest level at D1, but is often reported only at D2–D3.
Positive_regulation (reach) of D1 associated with fever
17) Confidence 0.02 Published 2003 Journal Filaria J Section Body Doc Link PMC2147657 Disease Relevance 0.96 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox