INT49567

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Context Info
Confidence 0.35
First Reported 1995
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.02
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (DRD1) plasma membrane (DRD1) nucleus (DRD1)
signal transducer activity (DRD1)
Anatomy Link Frequency
PFC 2
basal ganglia 1
DRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 5 100.00 Very High Very High Very High
dopamine receptor 5 100.00 Very High Very High Very High
Dopamine 164 93.60 High High
Morphine 3 90.80 High High
antagonist 9 85.52 High High
agonist 15 83.24 Quite High
midbrain 5 82.64 Quite High
Pyramidal cell 12 82.32 Quite High
Substantia nigra 6 79.44 Quite High
chemokine 3 72.04 Quite High
Disease Link Frequency Relevance Heat
Liver Disease 12 97.76 Very High Very High Very High
Disease 70 88.00 High High
Parkinson's Disease 5 86.92 High High
Attention Deficit Hyperactivity Disorder 36 81.24 Quite High
Cognitive Disorder 18 53.36 Quite High
Parkinsonian Disorders 39 52.40 Quite High
Congenital Anomalies 15 46.12 Quite Low
Schizophrenia 2 37.24 Quite Low
Drug Induced Neurotoxicity 5 30.00 Quite Low
Alcoholic Liver Cirrhosis 1 22.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, no effects of these opioid drugs were observed on D1 receptor stimulated contralateral rotational behavior and hand use induced by administration of SKF 81297 (0.3 mg/kg, IM).
Neg (no) Regulation (effects) of D1 receptor associated with opioid
1) Confidence 0.35 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568632 Disease Relevance 0.48 Pain Relevance 0.89
According to Arnsten et al., the role of the D1 receptor family in the regulation of PFC function has received particular focus, particularly as D1 receptors are found in high concentration in the PFC on dendritic spines.
Regulation (role) of D1 receptor in PFC
2) Confidence 0.30 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.25 Pain Relevance 0.22
CONCLUSIONS: Chronic ketamine users exhibited a regionally selective up-regulation of D1 receptor availability in the dorsolateral prefrontal cortex, a phenomenon observed following chronic dopamine depletion in animal studies.
Regulation (regulation) of D1 receptor in cortex
3) Confidence 0.27 Published 2005 Journal Am J Psychiatry Section Body Doc Link 16330601 Disease Relevance 0 Pain Relevance 0
In one study, Mousseau et al. (1993) used in vitro autoradiography and found decreased D2R levels in the globus pallidus and putamen with no change in D1-dopamine receptors (D1Rs) in the basal ganglia of patients with liver disease (Table 3).
Neg (no) Regulation (change) of D1-dopamine in basal ganglia associated with liver disease and dopamine receptor
4) Confidence 0.02 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.29 Pain Relevance 0.28
Of the previously known receptors AmphiAmR3 and R7 cluster with histamine receptor 4 in our phylogenetic tree, AmphiAmR1 clusters with dopamine receptors D1 and D5, AmphiAmR4, R5, R6, R9 and R11 is found in a non-resolved cluster with only amphioxus sequences while we placed AmphiD1/?
Regulation (found) of dopamine receptors D1 associated with dopamine receptor
5) Confidence 0.00 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2246102 Disease Relevance 0 Pain Relevance 0.16

General Comments

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