INT49569

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1995
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.38
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGDR) signal transducer activity (PTGDR)
Anatomy Link Frequency
striatum 1
PTGDR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 16 100.00 Very High Very High Very High
antagonist 7 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
Morphine 3 100.00 Very High Very High Very High
Dopamine 24 99.46 Very High Very High Very High
Ventral tegmentum 5 99.44 Very High Very High Very High
midbrain 4 98.96 Very High Very High Very High
Kappa opioid receptor 1 97.60 Very High Very High Very High
opioid receptor 1 90.52 High High
Nucleus accumbens 2 80.24 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 4 99.82 Very High Very High Very High
Parkinson's Disease 2 97.72 Very High Very High Very High
Disease 4 96.56 Very High Very High Very High
Anxiety Disorder 89 91.12 High High
Tics 1 77.92 Quite High
Congenital Anomalies 8 75.00 Quite High
Generalized Anxiety Disorder 1 8.40 Low Low
Obsessive-compulsive Disorder 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, in the present study the effects of the opioid antagonist naltrexone and agonist morphine on D1 and D2 receptor induced stimulation of motor behavior in the unilateral MPTP monkey model (n = 5) of PD were investigated.
Spec (investigated) Regulation (effects) of D2 receptor associated with parkinson's disease, antagonist, agonist, disease, opioid and morphine
1) Confidence 0.50 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568632 Disease Relevance 0.46 Pain Relevance 0.71
TH and alpha-synuclein mRNA levels were, in contrast, elevated in the VTA PN in heroin users with no change of the D2 receptor.
Neg (no) Regulation (change) of D2 receptor associated with ventral tegmentum and opiate addiction
2) Confidence 0.06 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.41 Pain Relevance 0.79
This might reflect a compensatory mechanism resulting from higher synaptic concentrations of dopamine in the striatum, leading to an elevation in the dopamine transporter and to a down-regulation of the D2 receptor.
Regulation (regulation) of D2 receptor in striatum associated with dopamine
3) Confidence 0.03 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.51 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox