INT49569

Context Info Confidence 0.50 First Reported 1995 Last Reported 2007 Negated 1 Speculated 1 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 1.38 Pain Relevance 2.03

plasma membrane (PTGDR) signal transducer activity (PTGDR)

Anatomy Link Frequency striatum 1 PTGDR (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 16 100.00 antagonist 7 100.00 Opioid 6 100.00 Morphine 3 100.00 Dopamine 24 99.46 Ventral tegmentum 5 99.44 midbrain 4 98.96 Kappa opioid receptor 1 97.60 opioid receptor 1 90.52 Nucleus accumbens 2 80.24

Disease Link Frequency Relevance Heat Opiate Addiction 4 99.82 Parkinson's Disease 2 97.72 Disease 4 96.56 Anxiety Disorder 89 91.12 Tics 1 77.92 Congenital Anomalies 8 75.00 Generalized Anxiety Disorder 1 8.40 Obsessive-compulsive Disorder 6 5.00 Cognitive Disorder 2 5.00 Depression 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, in the present study the effects of the opioid antagonist naltrexone and agonist morphine on D1 and D2 receptor induced stimulation of motor behavior in the unilateral MPTP monkey model (n = 5) of PD were investigated.

Spec (investigated) Regulation (effects) of D2 receptor associated with parkinson's disease, antagonist, agonist, disease, opioid and morphine

1) Confidence 0.50 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568632 Disease Relevance 0.46 Pain Relevance 0.71

TH and alpha-synuclein mRNA levels were, in contrast, elevated in the VTA PN in heroin users with no change of the D2 receptor.

Neg (no) Regulation (change) of D2 receptor associated with ventral tegmentum and opiate addiction

2) Confidence 0.06 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.41 Pain Relevance 0.79

This might reflect a compensatory mechanism resulting from higher synaptic concentrations of dopamine in the striatum, leading to an elevation in the dopamine transporter and to a down-regulation of the D2 receptor.

Regulation (regulation) of D2 receptor in striatum associated with dopamine

3) Confidence 0.03 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.51 Pain Relevance 0.52

General Comments

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