INT4957

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 87
Total Number 91
Disease Relevance 24.51
Pain Relevance 53.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
neurons 8
hippocampus 6
interneurons 3
brain 2
neuronal 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 829 100.00 Very High Very High Very High
antagonist 361 100.00 Very High Very High Very High
Dorsal horn 341 100.00 Very High Very High Very High
agonist 286 100.00 Very High Very High Very High
Spinal cord 201 100.00 Very High Very High Very High
Morphine 150 100.00 Very High Very High Very High
Neurotransmitter 47 100.00 Very High Very High Very High
anesthesia 40 100.00 Very High Very High Very High
methadone 39 100.00 Very High Very High Very High
Peripheral nervous system 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Diabetes Mellitus 181 99.96 Very High Very High Very High
Infarction 2 99.76 Very High Very High Very High
Hyperalgesia 35 99.72 Very High Very High Very High
Neuropathic Pain 276 99.68 Very High Very High Very High
Depression 583 99.66 Very High Very High Very High
Overactive Bladder 3 99.36 Very High Very High Very High
Nervous System Injury 297 99.24 Very High Very High Very High
Nociception 79 99.20 Very High Very High Very High
Hypoxia 15 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To avoid adverse effects of blocking N-methyl-D-aspartate receptors in the central nervous system, blocking N-methyl-D-aspartate receptor in peripheral nervous system is an ideal alternative.
Negative_regulation (blocking) of N-methyl-D-aspartate receptor in peripheral nervous system associated with peripheral nervous system, nmda receptor and central nervous system
1) Confidence 0.59 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20463582 Disease Relevance 0.25 Pain Relevance 0.39
Rats were administered dizocipline maleate (MK-801) at 0.25 mg/kg twice per day intraperitoneally from days 0-7 or from days 0-21 post-lesion to pre-emptively block the N-methyl-D-aspartate receptor.
Negative_regulation (block) of N-methyl-D-aspartate receptor associated with nmda receptor
2) Confidence 0.59 Published 1996 Journal Neuroscience Section Abstract Doc Link 8737421 Disease Relevance 0.80 Pain Relevance 1.23
These data suggest that blockade of the N-methyl-D-aspartate receptor is effective in reducing the infarct size after focal cerebral ischemia.
Negative_regulation (blockade) of N-methyl-D-aspartate receptor associated with brain hemorrhage, ischemia and nmda receptor
3) Confidence 0.57 Published 1990 Journal Stroke Section Abstract Doc Link 2237985 Disease Relevance 0.23 Pain Relevance 0.57
Although stereoisomers of methadone showed minimal stereoselectivity in most subtypes, R(-) methadone was highly selective in its inhibition of the NR1/2A combination.
Negative_regulation (inhibition) of NR1 associated with methadone
4) Confidence 0.57 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14980914 Disease Relevance 0.06 Pain Relevance 1.74
Morphine treatment for 7 days resulted in the development of tolerance to morphine's analgesic effect and produced a significant decrease in the steady-state NR1 mRNA levels in the spinal cord dorsal horn (by 16%), and an elevation in nucleus raphe magnus and medial thalamus (by 26 and 38%, respectively).
Negative_regulation (decrease) of NR1 mRNA in thalamus associated with raphe magnus, analgesic, dorsal horn, tolerance, thalamus, spinal cord and morphine
5) Confidence 0.54 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12829326 Disease Relevance 0.08 Pain Relevance 1.32
We have previously shown, using radioligand binding studies, that N-methyl-d-aspartate (NMDA) NR1 and NR2A receptor subunits density was decreased in the forebrain of morphine-dependent rats.
Negative_regulation (decreased) of NR1 in forebrain associated with morphine
6) Confidence 0.53 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17321516 Disease Relevance 0.12 Pain Relevance 0.63
Immunoblot analysis showed an antisense-concentration-dependent reduction in the NR1 subunit upon transient co-transfection of a plasmid expressing a sense NR1 gene and a plasmid expressing the antisense fragment into COS-7 cells.
Negative_regulation (reduction) of NR1
7) Confidence 0.51 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11376852 Disease Relevance 0.09 Pain Relevance 0.16
Sulindac treatment also attenuated an age-related decrease in the NR1 and NR2B NMDA receptor subunits and prevented an age-related increase in the pro-inflammatory cytokine, interleukin 1beta (IL-1beta), in the hippocampus.
Negative_regulation (decrease) of NR1 in hippocampus associated with inflammation, nmda receptor, hippocampus and cytokine
8) Confidence 0.51 Published 2004 Journal Neurobiol. Aging Section Abstract Doc Link 15123337 Disease Relevance 0.72 Pain Relevance 0.73
Indeed, it has been demonstrated that blockade of NMDA-R might stop the AMPA-R endocytosis [20].
Negative_regulation (blockade) of NMDA-R
9) Confidence 0.50 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3002330 Disease Relevance 0.28 Pain Relevance 0.28
Although patients' antibodies cause a dramatic reduction of NMDA-R in vivo, the metabolic effects on the regulation of glutamate are unknown.
Negative_regulation (reduction) of NMDA-R associated with glutamate
10) Confidence 0.50 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3002330 Disease Relevance 0.21 Pain Relevance 0.36
The level of NR1 mRNA was significantly decreased in the cerebral cortex, thalamus, and CA1 area of hippocampus in butorphanol tolerant and withdrawal (7 h after stopping the infusion) rats.
Negative_regulation (decreased) of NR1 in hippocampus associated with butorphanol, hippocampus, thalamus, withdrawal and cerebral cortex
11) Confidence 0.49 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.37
This observed decrease in binding at the N-methyl-D-aspartate receptor suggests a compensatory mechanism by which N-methyl-D-aspartate-mediated nociceptive events may be modulated.
Negative_regulation (decrease) of N-methyl-D-aspartate receptor associated with nociception and nmda receptor
12) Confidence 0.43 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477921 Disease Relevance 0.47 Pain Relevance 0.42
PURPOSE: Magnesium exerts a physiological block of the ion channel on the N-methyl-D-aspartate receptor, and may therefore prevent the induction of central sensitization.
Negative_regulation (block) of N-methyl-D-aspartate receptor associated with central sensitization and nmda receptor
13) Confidence 0.43 Published 2006 Journal Can J Anaesth Section Abstract Doc Link 17142651 Disease Relevance 0.07 Pain Relevance 0.26
After recombination into an adenoviral vector, this antisense fragment reduced the amount of endogenous NR1 protein in PC12 cells.
Negative_regulation (reduced) of NR1 protein
14) Confidence 0.43 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11376852 Disease Relevance 0.08 Pain Relevance 0.22
We examined the issue of NMDAR autoregulation by determining whether in vivo NMDAR blockade enhances trafficking of the NR2A subunits toward spines and more specifically to postsynaptic densities (PSDs) of already mature synapses.
Spec (whether) Negative_regulation (blockade) of NMDAR in synapses
15) Confidence 0.43 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560119 Disease Relevance 0 Pain Relevance 0.12
Xenon's analgesic effect was speculated to result from the inhibition of the N-methyl-D-aspartate receptor in vivo.
Negative_regulation (inhibition) of N-methyl-D-aspartate receptor associated with nmda receptor and analgesic
16) Confidence 0.42 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12401615 Disease Relevance 0.30 Pain Relevance 0.59
Methadone is of particular interest because it possesses both micro-receptor agonist and N-methyl-d-aspartate receptor antagonist activities.
Negative_regulation (possesses) of N-methyl-d-aspartate receptor associated with antagonist and agonist
17) Confidence 0.42 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17325516 Disease Relevance 0.42 Pain Relevance 1.44
With respect to the numbers of NR1-/Fos-ir double-labeled neurons, significant increases were only observed in a subset of these pontomedullary nuclei.
Negative_regulation (bers of) of NR1 in neurons
18) Confidence 0.42 Published 1998 Journal Brain Res. Section Abstract Doc Link 9853114 Disease Relevance 0.07 Pain Relevance 0.30
The phosphorylation levels of GluR1 and NR1 subunits decreased in parallel with those of phospho-Thr-34 DARPP-32, supporting the hypothesis that morphine challenge elicited a decrease in PKA activity in morphine-sensitized rats.
Negative_regulation (decreased) of NR1 associated with morphine
19) Confidence 0.42 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.02
The non-competitive NMDA-receptor antagonist, MK-801, and a specific inhibitor of the ERK1/2 pathway, U0126, significantly attenuated the injury-elicited increases in Homer1a mRNA when compared to saline-treated animals.
Negative_regulation (antagonist) of NMDA-receptor associated with antagonist and injury
20) Confidence 0.42 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16448751 Disease Relevance 0.32 Pain Relevance 0.54

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