INT4958

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Context Info
Confidence 0.65
First Reported 1992
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 3.40
Pain Relevance 5.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pcyt1b) biosynthetic process (Pcyt1b) nucleotidyltransferase activity (Pcyt1b)
Anatomy Link Frequency
spinal 2
spinal cords 1
muscles 1
nucleus 1
dorsal thalamus 1
Pcyt1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 233 99.96 Very High Very High Very High
anesthesia 12 99.44 Very High Very High Very High
Central grey 17 99.16 Very High Very High Very High
Spinal cord 426 98.94 Very High Very High Very High
Calcitonin gene-related peptide 10 98.64 Very High Very High Very High
Locus ceruleus 8 97.80 Very High Very High Very High
Thalamus 124 97.56 Very High Very High Very High
Dorsal horn 146 97.24 Very High Very High Very High
Sciatic nerve 138 97.12 Very High Very High Very High
midbrain 9 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vibrio Infection 31 100.00 Very High Very High Very High
Nociception 33 99.76 Very High Very High Very High
Urological Neuroanatomy 54 99.16 Very High Very High Very High
Spinal Cord Injury 86 99.08 Very High Very High Very High
Injury 79 96.88 Very High Very High Very High
Body Weight 4 95.68 Very High Very High Very High
Frailty 5 90.60 High High
Syndrome 2 87.76 High High
Sciatic Neuropathy 64 84.56 Quite High
Neuropathic Pain 4 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stereotaxic injections of the retrograde tracer cholera toxin beta -subunit (CTb) were made in each of the intralaminar nuclei of the dorsal thalamus: the lateral parafascicular, medial parafascicular, central lateral, paracentral, oval paracentral, and central medial nuclei; in the midline thalamic nuclei-the paraventricular, intermediodorsal, mediodorsal, paratenial, rhomboid, reuniens, and submedius nuclei; and, in the anteroventral, parvicellular part of the ventral posterior, and caudal ventral medial nuclei.
Gene_expression (injections) of CTb in dorsal thalamus associated with vibrio infection and thalamus
1) Confidence 0.65 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 12012375 Disease Relevance 0.10 Pain Relevance 0.16
After 1 week of transport, the (L/S) spinal cords were cryosectioned and immunohistochemically stained for CTb, the nociceptive-specific marker calcitonin gene-related peptide (CGRP), and the myelinated fiber marker RT97.
Gene_expression (stained) of CTb in spinal cords associated with nociception and calcitonin gene-related peptide
2) Confidence 0.58 Published 2009 Journal Neuroscience Section Abstract Doc Link 19146928 Disease Relevance 1.02 Pain Relevance 0.51
Cholera toxin B subunit (CTB), a retrograde transport marker, was injected into the rat gastrocnemius muscles, and changes in CTB-labeling pattern of motoneurons and primary afferent neurons at the level L4 and L5 after spinal cord hemisection of the L1 level were observed in conjunction with the alterations of chemical messengers such as serotonin (5-HT), calcitonin gene-related peptide (CGRP), substance P (SP), galanin (Gal), Met-enkephalin (Enk), and neuropeptide Y (NPY).
Gene_expression (injected) of CTB in muscles associated with neuropeptide, vibrio infection, enkephalin, serotonin, substance p, calcitonin gene-related peptide and spinal cord
3) Confidence 0.49 Published 1992 Journal J Hirnforsch Section Abstract Doc Link 1282529 Disease Relevance 0.10 Pain Relevance 0.52
Nor does the spinal level of CTB injection in this study provide an explanation for the discrepancies found in spinal trigeminal labelling.
Gene_expression (injection) of CTB in spinal
4) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919385 Disease Relevance 0 Pain Relevance 0.10
This discrepancy is not explained by restriction of the CTB injection to the ventral horn in the G140 fetus, because the G55 fetus also showed only minor labelling in the spinal trigeminal nucleus.
Gene_expression (injection) of CTB in spinal trigeminal nucleus
5) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919385 Disease Relevance 0 Pain Relevance 0.16
The cells were present at a much higher density ipsilateral to the side of the CTB injection.
Gene_expression (injection) of CTB
6) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919385 Disease Relevance 0 Pain Relevance 0.44
At the level of the mid-medulla, CTB labelled cells were present in the gigantocellular reticular nucleus (Fig. 5) bilaterally.
Gene_expression (present) of CTB in gigantocellular reticular nucleus associated with medulla
7) Confidence 0.34 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919385 Disease Relevance 0 Pain Relevance 0.43
We verified that all ascending sensory fibres were cut by lack of CTB staining in the dorsal nuclei of medulla after injection of the tracer into the sciatic nerve.


Gene_expression (staining) of CTB in sciatic nerve associated with medulla and sciatic nerve
8) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.24 Pain Relevance 0.57
Furthermore, two transganglionic tracers, horseradish peroxidase conjugates of cholera toxin B subunit (CTB) and isolectin-B(4) of Bandeiraea simplicifolia (IB(4)), were injected into the opposite sides of the sciatic nerve to trace myelinated and unmyelinated afferent terminations, respectively, in the spinal dorsal horn.
Gene_expression (conjugates) of CTB in spinal associated with spinal dorsal horn, vibrio infection, sciatic nerve and unmyelinated
9) Confidence 0.27 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12684478 Disease Relevance 0.36 Pain Relevance 0.79
After spinal cord injury, the transport of CTB was interrupted and no CTB labeled nerve terminals were observed in the gracile nucleus indicating the complete injury of ascending sensory neurons.
Neg (no) Gene_expression (labeled) of CTB in nerve associated with injury and spinal cord
10) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.44 Pain Relevance 0.46
The retrogradely transported marker, cholera toxin beta-subunit (CTb) was then injected in the dorsolateral PAG, CS, PF, ZI and medial to the LC.
Gene_expression (injected) of CTb in medial associated with locus ceruleus, vibrio infection and central grey
11) Confidence 0.24 Published 2001 Journal Brain Res. Section Abstract Doc Link 11701131 Disease Relevance 0.65 Pain Relevance 0.66
3.8 mm) through an injection of CTb that was targeted on the PoT nucleus (experiment DI1).
Gene_expression (injection) of CTb in nucleus
12) Confidence 0.23 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2658017 Disease Relevance 0 Pain Relevance 0.03
m in the C7 segment, and this was subsequently compared with the numbers of retrogradely labeled lamina I neurons found in this segment in the experiments in which CTb and/or Fluoro-Gold were injected.
Gene_expression (injected) of CTb in neurons
13) Confidence 0.23 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2658017 Disease Relevance 0 Pain Relevance 0.08
In this way the mean number of retrogradely labeled lamina I cells containing CTb, Fluoro-Gold, or both tracers per 600 ?
Gene_expression (containing) of CTb in lamina
14) Confidence 0.23 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2658017 Disease Relevance 0 Pain Relevance 0.09
Two of these (arrows) contain both CTb and Fluoro-Gold, and others (two of which are indicated with arrowheads) are labeled with CTb but not Fluoro-Gold.
Gene_expression (labeled) of CTb
15) Confidence 0.23 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2658017 Disease Relevance 0 Pain Relevance 0.10
Drawings of the spread of tracer for the three experiments in which CTb injections were targeted on the left gracile nucleus are illustrated in Fig. 4 (Experiments 4–6, and an example of an injection site is shown in Fig. 5).
Gene_expression (injections) of CTb in gracile nucleus
16) Confidence 0.19 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2635481 Disease Relevance 0 Pain Relevance 0.09
Cholera toxin B subunit (CTb) tracing
Gene_expression (tracing) of CTb associated with vibrio infection
17) Confidence 0.15 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0.29 Pain Relevance 0.13
In addition, it is unlikely to be due to lack of sensitivity of detection for the tracers, since there was a clear distinction between cells that were positive and negative for CTb and Fluorogold.
Neg (negative) Gene_expression (positive) of CTb
18) Confidence 0.09 Published 2009 Journal Neuroscience Section Body Doc Link PMC2784948 Disease Relevance 0.07 Pain Relevance 0.16
Sections through the CTb injection were reacted with goat anti-CTb (List Biological Laboratories, Campbell, CA, USA; diluted 1:50,000) using an immunoperoxidase method as described previously (Todd et al., 2000).
Gene_expression (injection) of CTb
19) Confidence 0.09 Published 2009 Journal Neuroscience Section Body Doc Link PMC2784948 Disease Relevance 0.06 Pain Relevance 0.19

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