INT49584

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Context Info
Confidence 0.52
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.16
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
hepatocytes 1
Glul (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 2 100.00 Very High Very High Very High
Thermal hyperalgesia 1 99.28 Very High Very High Very High
Paracetamol 20 99.00 Very High Very High Very High
primary afferent fibers 1 93.96 High High
Central nervous system 1 92.72 High High
gABA 5 89.24 High High
GABAergic 1 85.44 High High
Pain threshold 1 81.44 Quite High
IPN 1 76.56 Quite High
Inflammation 1 37.12 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 1 99.28 Very High Very High Very High
Generalized Anxiety Disorder 2 96.20 Very High Very High Very High
Necrosis 2 95.44 Very High Very High Very High
Nociception 7 94.96 High High
Hepatotoxicity 2 94.44 High High
Targeted Disruption 1 83.84 Quite High
Pain 1 81.44 Quite High
Inflammatory Pain 1 76.56 Quite High
Overdose 1 54.48 Quite High
Hyperammonemia 2 38.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of carbamyl phosphate synthetase-I and glutamine synthetase by hepatotoxic doses of acetaminophen in mice.
Negative_regulation (Inhibition) of glutamine synthetase associated with paracetamol
1) Confidence 0.52 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 9344900 Disease Relevance 0.17 Pain Relevance 0.48
Since the intracellular activity of glutamine synthetase is significantly decreased after the administration of APAP to hepatocytes in culture, it is likely that the arylation of this enzyme may be involved in the ensuing hepatotoxicity.
Negative_regulation (decreased) of glutamine synthetase in hepatocytes associated with paracetamol and hepatotoxicity
2) Confidence 0.36 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7570608 Disease Relevance 0.20 Pain Relevance 0.79
Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 65.
Negative_regulation (lacking) of glutamate decarboxylase associated with glutamate and thermal hyperalgesia
3) Confidence 0.20 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 19571163 Disease Relevance 0.79 Pain Relevance 0.60

General Comments

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