INT4960

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Context Info
Confidence 0.70
First Reported 1973
Last Reported 2011
Negated 10
Speculated 6
Reported most in Abstract
Documents 285
Total Number 292
Disease Relevance 256.73
Pain Relevance 65.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
CSF 56
macrophage 18
blood 13
plasma 10
granulocyte 8
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1866 100.00 Very High Very High Very High
Inflammation 1766 100.00 Very High Very High Very High
chemokine 815 100.00 Very High Very High Very High
Multiple sclerosis 675 100.00 Very High Very High Very High
metalloproteinase 273 100.00 Very High Very High Very High
Inflammatory mediators 88 100.00 Very High Very High Very High
antagonist 83 100.00 Very High Very High Very High
addiction 13 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
Clonidine 54 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 3229 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2971 100.00 Very High Very High Very High
INFLAMMATION 1973 100.00 Very High Very High Very High
Dementia 616 100.00 Very High Very High Very High
Multiple Sclerosis 210 100.00 Very High Very High Very High
Adhesions 123 100.00 Very High Very High Very High
Status Epilepticus 16 100.00 Very High Very High Very High
Pleural Effusion 9 100.00 Very High Very High Very High
Disease Progression 222 99.96 Very High Very High Very High
Splenic Rupture 13 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antibody titer to varicella zoster virus (VZV) was elevated in both the serum and CSF.
Positive_regulation (elevated) of CSF in CSF associated with herpes zoster
1) Confidence 0.70 Published 2008 Journal J. Neurol. Sci. Section Abstract Doc Link 18456282 Disease Relevance 1.37 Pain Relevance 0.17
Clonidine also was associated with concentration-dependent sedation; decreased mean arterial blood pressure, heart rate, and CSF norepinephrine concentration; and increased CSF acetylcholine concentration.
Positive_regulation (increased) of CSF in CSF
2) Confidence 0.70 Published 1995 Journal Anesthesiology Section Body Doc Link 7605017 Disease Relevance 0 Pain Relevance 0
Increased CSF protein and depressed CSF glucose levels were seen in HIV-negative cases, which differed from HIV-positive cases, where a slight change was noted.
Positive_regulation (Increased) of CSF in CSF associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.70 Published 2004 Journal Southeast Asian J. Trop. Med. Public Health Section Abstract Doc Link 15906631 Disease Relevance 1.65 Pain Relevance 0.09
Non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat the condition of rheumatoid arthritis, where levels of prostaglandin E2 (PGE2) and granulocyte macrophage-colony stimulating factor (GM-CSF) are elevated in the synovial fluid.
Positive_regulation (elevated) of granulocyte macrophage-colony stimulating factor in macrophage associated with inflammation, rheumatoid arthritis and cinod
4) Confidence 0.69 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.20 Pain Relevance 0.64
The purpose of the present study was to evaluate whether intravenous (I.V.) clonidine is also able to increase CSF ACh in humans.
Spec (whether) Positive_regulation (increase) of CSF ACh in CSF associated with clonidine
5) Confidence 0.69 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9085961 Disease Relevance 0.09 Pain Relevance 0.96
Inflammatory disorders of the central nervous system and dementia due to other causes in HIV-seronegative patients were not associated with increased CSF NPY-LI.
Neg (not) Positive_regulation (increased) of CSF in central nervous system associated with dementia, inflammation, acquired immune deficiency syndrome or hiv infection and central nervous system
6) Confidence 0.67 Published 1996 Journal J. Neurol. Sci. Section Abstract Doc Link 8815163 Disease Relevance 1.12 Pain Relevance 0.40
CSF beta 2-M level increases both in Human Immunodeficiency Virus type 1 (HIV-1) related and in opportunistic CNS syndromes, confirming that beta 2-M is a non specific marker of CNS involvement in AIDS.
Positive_regulation (increases) of CSF beta 2-M in CNS associated with syndrome, acquired immune deficiency syndrome or hiv infection and central nervous system
7) Confidence 0.66 Published 1992 Journal J Clin Lab Immunol Section Abstract Doc Link 11270518 Disease Relevance 1.44 Pain Relevance 0.27
The CSF IgG index was also elevated.
Positive_regulation (elevated) of CSF IgG in CSF
8) Confidence 0.65 Published 2004 Journal Rinsho Shinkeigaku Section Abstract Doc Link 15568483 Disease Relevance 1.55 Pain Relevance 0.41
Although yohimbine robustly increased CSF NE levels and appeared to increase CSF CRH levels, these effects were not seen after naloxone or placebo administration.
Positive_regulation (increased) of CSF in CSF associated with narcan
9) Confidence 0.62 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11095445 Disease Relevance 0.14 Pain Relevance 0.44
In the first trial, patients were assigned to regimens of increasing dose levels of carboplatin (starting at 400 mg/m2) and fixed doses and schedules of cyclophosphamide (600 mg/m2) and rHuGM-CSF (10 micrograms/kg given subcutaneously once daily on days 2-11).
Positive_regulation (increasing) of rHuGM-CSF
10) Confidence 0.61 Published 1991 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 1770554 Disease Relevance 0.24 Pain Relevance 0
With each episode he had severe occipital headache associated with a mononuclear pleocytosis and an increase in CSF protein.
Positive_regulation (increase) of CSF associated with leukocytosis and headache
11) Confidence 0.61 Published 1991 Journal Neurology Section Abstract Doc Link 1944917 Disease Relevance 0.89 Pain Relevance 0.10
A lumbar puncture demonstrated a significant lymphocytic response and an elevated CSF protein level on the day of and 24 days after the headache despite the absence of any other clinical symptoms.
Positive_regulation (elevated) of CSF in puncture associated with headache and lumbar puncture related headaches
12) Confidence 0.61 Published 1980 Journal Arch. Neurol. Section Abstract Doc Link 7387469 Disease Relevance 0.37 Pain Relevance 0.36
The ratio of [14C]sucrose to morphine increased by nearly sevenfold in cisternal CSF, indicating clearance of morphine relative to [14C]sucrose as the compounds ascend in the CSF axis.
Positive_regulation (increased) of CSF associated with morphine
13) Confidence 0.61 Published 1986 Journal J Pharmacol Methods Section Abstract Doc Link 3784573 Disease Relevance 0 Pain Relevance 1.09
Immunohistochemistry staining using an anti-granulocyte colony-stimulating factor (G-CSF) monoclonal antibody demonstrated many tumor cells containing G-CSF as well as an increased level of serum G-CSF.
Positive_regulation (increased) of G-CSF in granulocyte associated with cancer
14) Confidence 0.61 Published 2009 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 19348277 Disease Relevance 0.53 Pain Relevance 0.08
Serum levels of uric acid (UA) and lactic dehydrogenase (LDH) increased under G-CSF, and platelets decreased after G-CSF discontinuation.
Positive_regulation (increased) of G-CSF in platelets
15) Confidence 0.60 Published 1999 Journal Ann. Hematol. Section Abstract Doc Link 10211753 Disease Relevance 0.18 Pain Relevance 0.16
Non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat the condition of rheumatoid arthritis, where levels of prostaglandin E2 (PGE2) and granulocyte macrophage-colony stimulating factor (GM-CSF) are elevated in the synovial fluid.
Positive_regulation (elevated) of GM-CSF in macrophage associated with inflammation, rheumatoid arthritis and cinod
16) Confidence 0.60 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.19 Pain Relevance 0.64
He was treated conservatively, his symptoms resolved, and follow-up MR imaging showed resolution of the CSF accumulation.
Positive_regulation (accumulation) of CSF in CSF associated with imagery
17) Confidence 0.60 Published 1998 Journal J Spinal Disord Section Abstract Doc Link 9493775 Disease Relevance 0.51 Pain Relevance 0.27
After hemipelvectomy, when local recurrence and metastasis were identified, leukocytosis appeared and an elevated level of serum granulocyte-colony-stimulating factor (G-CSF) was also recognized.
Positive_regulation (elevated) of G-CSF in granulocyte associated with leukocytosis, metastasis and recurrence
18) Confidence 0.59 Published 2006 Journal World J Surg Oncol Section Abstract Doc Link PMC1526734 Disease Relevance 1.61 Pain Relevance 0
However, to our knowledge, no bone tumor with leukocytosis plus an elevated serum G-CSF level has been reported.
Positive_regulation (elevated) of G-CSF associated with leukocytosis and bone cancer
19) Confidence 0.59 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1526734 Disease Relevance 2.46 Pain Relevance 0.07
This chondrosarcoma with leukocytosis and an elevated serum G-CSF level is the first such report not only of chondrosarcoma, but also of any such primary bone tumor with leukocytosis.


Positive_regulation (elevated) of G-CSF associated with chondrosarcoma, leukocytosis and bone cancer
20) Confidence 0.59 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1526734 Disease Relevance 2.44 Pain Relevance 0.21

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