INT49603

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Context Info
Confidence 0.21
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.82
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT4) Golgi apparatus (FUT4) carbohydrate metabolic process (FUT4)
Anatomy Link Frequency
B cells 1
FUT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 130 99.68 Very High Very High Very High
Inflammation 16 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
iatrogenic 5 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 138 99.68 Very High Very High Very High
Pancreatitis 1 56.24 Quite High
Sprains And Strains 30 50.00 Quite Low
Disease 20 15.00 Low Low
Injury 32 5.00 Very Low Very Low Very Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low
Epstein-barr Virus 16 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Diabetes Mellitus 14 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TCF2, CXCL10, and FUT4 were all up regulated in the MS samples whereas CDC5L, TNFRSF19 and HLA-DR were down regulated (Table 5).
Regulation (regulated) of FUT4 associated with multiple sclerosis
1) Confidence 0.21 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.48 Pain Relevance 0.24
Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.


Regulation (regulated) of FUT4 in B cells associated with multiple sclerosis
2) Confidence 0.09 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2227948 Disease Relevance 0.28 Pain Relevance 0.14
Unlike FCT, FET was not affected by oral enzyme supplementation.
Neg (not) Regulation (affected) of FCT
3) Confidence 0.04 Published 1995 Journal Am. J. Gastroenterol. Section Body Doc Link 7572904 Disease Relevance 0.06 Pain Relevance 0
Secondary dependent variables include NPRS, modified FABQ, PANAS, LExSES, and GROC scores at 1 week, 4 weeks, 6 months, 1 year, and 2 years.
Regulation (modified) of LExSES
4) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2967502 Disease Relevance 0 Pain Relevance 0

General Comments

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