INT49606

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Context Info
Confidence 0.66
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 15.78
Pain Relevance 14.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
brain 3
peripheral nerve 2
plasma 1
midbrain 1
TRG 1
Il1rn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 67 100.00 Very High Very High Very High
anakinra 10 100.00 Very High Very High Very High
diclofenac 2 100.00 Very High Very High Very High
intrathecal 2 99.98 Very High Very High Very High
Clonidine 9 99.84 Very High Very High Very High
antidepressant 60 99.58 Very High Very High Very High
Inflammatory marker 5 99.56 Very High Very High Very High
withdrawal 8 99.26 Very High Very High Very High
midbrain 40 99.20 Very High Very High Very High
Hyperalgesia 93 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 34 100.00 Very High Very High Very High
Targeted Disruption 4 99.98 Very High Very High Very High
INFLAMMATION 387 99.56 Very High Very High Very High
Rheumatoid Arthritis 8 99.28 Very High Very High Very High
Hyperalgesia 99 99.12 Very High Very High Very High
Pain 78 98.64 Very High Very High Very High
Neuropathic Pain 52 98.32 Very High Very High Very High
Ganglion Cysts 10 98.22 Very High Very High Very High
Hypersensitivity Vasculitis 2 97.60 Very High Very High Very High
Necrosis 27 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(n = 101; females/males: n = 74/27) and the IL-1Ra polymorphism (n = 94; females/males: n = 73/21).
Gene_expression (polymorphism) of IL-1Ra
1) Confidence 0.66 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515903 Disease Relevance 0.08 Pain Relevance 0.04
Several studies support a neuroprotective function of IL-1Ra (Licinio and Wong 1999), which is constitutively expressed in brain (Licinio et al 2007).
Gene_expression (expressed) of IL-1Ra in brain
2) Confidence 0.59 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515903 Disease Relevance 0.23 Pain Relevance 0.51
However, in brain the chronic administration of antidepressants led to an increased expression of IL-1Ra mRNA and IL-1?
Gene_expression (expression) of IL-1Ra in brain associated with antidepressant
3) Confidence 0.59 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515903 Disease Relevance 0.33 Pain Relevance 0.51
The firing rates of the Adelta-TRG neuronal spontaneous activity were current-dependently decreased by local iontophoretic application of an interleukin I receptor type I antagonist (IL-1ra) in inflamed rats, but not in controls, and current-dependently increased by iontophoretic application of interleukin 1beta (IL-1beta) in both control and inflamed rats.
Gene_expression (application) of IL-1ra in TRG associated with antagonist, trigeminal ganglion and adelta
4) Confidence 0.50 Published 2008 Journal Brain Behav. Immun. Section Abstract Doc Link 18440198 Disease Relevance 1.33 Pain Relevance 0.80
Similar to neutrophil infiltration, IL-1Ra infusion did not affect CD68-positive cell infiltration.
Gene_expression (infusion) of IL-1Ra in neutrophil
5) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.02 Pain Relevance 0.07
Therefore, the doses of BzATP, OxATP and IL-1Ra were 43 ?
Gene_expression (doses) of IL-1Ra
6) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.40 Pain Relevance 0.15
These results suggest that interleukin-1 beta produces biphasic effects on the mechanical nociceptive threshold through the interleukin-1 receptor in the brain and that a corticotropin-releasing factor-mediated pathway is involved.
Gene_expression (produces) of interleukin-1 receptor in brain associated with nociception
7) Confidence 0.31 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8741165 Disease Relevance 0.58 Pain Relevance 0.53
CONCLUSION(S): Our results suggested that decreased levels of PF IL-1ra in patients with endometriosis and disease-related dysmenorrhea may play an important role in the pathogenesis of this disease.


Gene_expression (levels) of PF IL-1ra
8) Confidence 0.30 Published 2007 Journal Fertil. Steril. Section Body Doc Link 17292896 Disease Relevance 0.06 Pain Relevance 0
Restricted areas showed elevations in messenger RNA expression of interleukin-1 receptor antagonist, interleukin-6, inducible nitric oxide synthase, interferon-gamma, and inducible cyclooxygenase.
Gene_expression (expression) of interleukin-1 receptor associated with antagonist
9) Confidence 0.27 Published 2000 Journal Neuroscience Section Abstract Doc Link 10683422 Disease Relevance 0.55 Pain Relevance 0.45
Secondary analyses explored whether there were any associations between IL1RN and IL6 genotype and other inflammatory markers.
Gene_expression (genotype) of IL1RN associated with inflammatory marker
10) Confidence 0.26 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC425582 Disease Relevance 0.48 Pain Relevance 0.24
This PPT elevation was not influenced by i.v. injection of alpha-helical CRF or IL-1ra.
Gene_expression (injection) of IL-1ra
11) Confidence 0.25 Published 2004 Journal Am. J. Chin. Med. Section Abstract Doc Link 15315264 Disease Relevance 0.47 Pain Relevance 1.23
The TNF-alpha (10 pg)-induced reduction in paw withdrawal latency was blocked by simultaneous injection of diclofenac (1 ng), a cyclooxygenase inhibitor, or interleukin-1 receptor antagonist (IL-1 ra, 10 ng).
Gene_expression (injection) of interleukin-1 receptor in paw associated with antagonist, rheumatoid arthritis, diclofenac and withdrawal
12) Confidence 0.12 Published 1996 Journal Neuroimmunomodulation Section Abstract Doc Link 8945729 Disease Relevance 1.18 Pain Relevance 0.56
This reaction was also blocked by the simultaneous injection of IL-1ra (50 ng/kg) and Na salicylate (500 ng/kg).
Gene_expression (injection) of IL-1ra
13) Confidence 0.11 Published 1995 Journal Brain Res. Section Abstract Doc Link 8624721 Disease Relevance 0.53 Pain Relevance 0.37
RhIL-1 beta (20 pg/kg)-induced hyperalgesia was completely blocked by the simultaneous injection of IL-1 receptor antagonist (IL-1ra, 20 ng/kg), Na salicylate (200 ng/kg) or alpha-melanocyte-stimulating hormone alpha-MSH, 20 ng/kg).
Gene_expression (injection) of IL-1ra in melanocyte associated with hyperalgesia and antagonist
14) Confidence 0.11 Published 1995 Journal Brain Res. Section Abstract Doc Link 8624721 Disease Relevance 0.52 Pain Relevance 0.23
Moreover, deletion of IL-1 receptor type 1 or transgenic overexpression of the naturally occurring IL-1 receptor antagonist (IL-1RA) delay the onset and severity of pain associated with peripheral nerve injury [10].
Gene_expression (overexpression) of IL-1RA in peripheral nerve associated with targeted disruption, pain, nervous system injury, antagonist and peripheral nerve injury
15) Confidence 0.10 Published 2008 Journal Mol Pain Section Body Doc Link PMC2625335 Disease Relevance 1.66 Pain Relevance 1.23
Moreover, deletion of IL-1 receptor type 1 or transgenic overexpression of the naturally occurring IL-1 receptor antagonist (IL-1RA) delay the onset and severity of pain associated with peripheral nerve injury [10].
Gene_expression (overexpression) of IL-1 receptor antagonist in peripheral nerve associated with targeted disruption, pain, nervous system injury, antagonist and peripheral nerve injury
16) Confidence 0.10 Published 2008 Journal Mol Pain Section Body Doc Link PMC2625335 Disease Relevance 1.66 Pain Relevance 1.23
Together with a group of so-called proinflammatory cytokines including tumor necrosis factor (TNF), IL-1, IL-6 and IL-8, a variety of antiinflammatory cytokines including IL-10 and the IL-1 receptor antagonist (IL-1ra) are also produced during humoral and cell-mediated immune responses [53].
Gene_expression (produced) of IL-1ra associated with necrosis, inflammation, cancer, antagonist and cytokine
17) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.30 Pain Relevance 1.05
Chinese Han AS patients and ethnically matched healthy controls were genotyped for five single nucleotide polymorphisms (IL1beta+3953, beta-511, F10.3, RN.4, RN.6/1) and the IL1RN.VNTR of IL-1 gene cluster.
Gene_expression (beta-511) of IL1RN
18) Confidence 0.06 Published 2010 Journal Int. J. Immunogenet. Section Abstract Doc Link 19930406 Disease Relevance 0.16 Pain Relevance 0.16
Administration of IL-1ra produces changes in ventral midbrain cytokine content and reduces the cell loss produced by LPS and 6-OHDA
Gene_expression (produces) of IL-1ra in midbrain associated with midbrain and cytokine
19) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2292163 Disease Relevance 0.05 Pain Relevance 0.80
Intrathecal administration of IL-1ra and soluble TNF-?
Gene_expression (administration) of IL-1ra associated with intrathecal
20) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992508 Disease Relevance 1.18 Pain Relevance 1.13

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