INT49612

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Context Info
Confidence 0.25
First Reported 1995
Last Reported 1997
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
hypothalamus 2
caudate-putamen 2
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 8 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
Neuropeptide 2 94.84 High High
Opioid 1 78.04 Quite High
tolerance 2 62.96 Quite High
dopamine receptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 12 95.00 High High
Dyskinesias 5 69.92 Quite High
Targeted Disruption 1 64.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proenkephalin gene regulation in the neuroendocrine hypothalamus: a model of gene regulation in the CNS.
Regulation (regulation) of Regulation (regulation) of Proenkephalin gene in hypothalamus associated with enkephalin
1) Confidence 0.25 Published 1995 Journal Am. J. Physiol. Section Title Doc Link 7573416 Disease Relevance 0.06 Pain Relevance 0.27
The effect of chronic treatment with the D2 dopamine agonist U91356A or L-DOPA therapy on the regulation of preproenkephalin (PPE) mRNA was investigated in the caudate-putamen of previously drug-naive cynomolgus monkeys Macaca fascicularis rendered parkinsonian by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Spec (investigated) Regulation (effect) of Regulation (regulation) of preproenkephalin in caudate-putamen associated with parkinson's disease, dopamine and agonist
2) Confidence 0.03 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9387863 Disease Relevance 0.56 Pain Relevance 0.17

General Comments

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