INT49623

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 39
Total Number 41
Disease Relevance 12.40
Pain Relevance 21.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
neurons 4
brain 3
synapses 3
shell 2
neural 2
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 282 100.00 Very High Very High Very High
Glutamate receptor 182 100.00 Very High Very High Very High
antagonist 174 100.00 Very High Very High Very High
qutenza 13 100.00 Very High Very High Very High
Clonidine 5 99.84 Very High Very High Very High
nMDA receptor 579 99.76 Very High Very High Very High
Nucleus accumbens 17 99.68 Very High Very High Very High
isoflurane 16 99.68 Very High Very High Very High
gABA 30 99.62 Very High Very High Very High
dopamine receptor 11 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 46 100.00 Very High Very High Very High
Stress 159 99.68 Very High Very High Very High
Nociception 35 99.60 Very High Very High Very High
Hypothermia 4 99.46 Very High Very High Very High
Hypotension 5 99.44 Very High Very High Very High
Targeted Disruption 12 99.32 Very High Very High Very High
Disease 35 98.96 Very High Very High Very High
Convulsion 18 98.46 Very High Very High Very High
INFLAMMATION 74 97.36 Very High Very High Very High
Cv Unclassified Under Development 8 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The synaptic and calcium current components of the epileptiform activity were removed by using a "synapse blocking solution" in which calcium was replaced with magnesium, and glutamate receptor activity was blocked using the glutamate antagonists 2-amino-5-phosphonovalerate and 6-cyano-7-nitroquinoxaline-2,3-dione.
Negative_regulation (blocked) of glutamate receptor in synapse associated with glutamate, antagonist and glutamate receptor
1) Confidence 0.59 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7823106 Disease Relevance 0 Pain Relevance 0.28
Caspace 1, D2 dopamine receptor, GABA-A alpha1 subunit, GRIA 1/3/4, Galphai2, PSD-95 and CREB were down-regulated in the NAc shell with morphine administration.
Negative_regulation (down-regulated) of GRIA 1 in shell associated with nucleus accumbens, gaba, dopamine receptor and morphine
2) Confidence 0.57 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.23
Because cerebral protection by hypothermia may involve a decrease in glutamate receptor activity, we also examined the interaction of temperature and isoflurane on glutamate receptor inhibition.
Negative_regulation (decrease) of glutamate receptor associated with hypothermia, glutamate receptor and isoflurane
3) Confidence 0.51 Published 1994 Journal Anesthesiology Section Abstract Doc Link 7992916 Disease Relevance 0.55 Pain Relevance 0.50
Conversely, the amount of GluR1 was decreased by 25% in the cytosolic fraction (Fig. 4C; p < 0.05) and correspondingly increased by 23% in the membrane fraction (Fig. 4D; p < 0.05) at 24 h post-CFA injection (n = 8) compared with the values of the naïve group (n = 8).
Negative_regulation (decreased) of GluR1
4) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.16 Pain Relevance 0.23
The levels of mRNA for the flop form of GluR-A were decreased in the CA3 of hippocampus (8%) of the rat brain.
Negative_regulation (decreased) of GluR-A in brain associated with hippocampus
5) Confidence 0.41 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10822164 Disease Relevance 0.11 Pain Relevance 0.98
Organotypic hippocampal slice cultures are sensitive to both NMDA and non-NMDA glutamate receptor blockade and thus represent a useful in vitro system for the study of ischaemic neurodegeneration paralleling results reported using in vivo models of ischaemia.
Negative_regulation (blockade) of glutamate receptor associated with glutamate receptor and cv unclassified under development
6) Confidence 0.41 Published 1997 Journal Brain Res. Section Abstract Doc Link 9163539 Disease Relevance 1.08 Pain Relevance 0.64
It was found that the GluR1-flop mRNA was up-regulated at 2 h-5 h (P<0.05), down-regulated at 3 d (P=0.05), and returned to control levels at 7 d following inflammation.
Negative_regulation (down-regulated) of GluR1 associated with inflammation
7) Confidence 0.40 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295247 Disease Relevance 0.82 Pain Relevance 0.60
Consistent results were obtained by double labeling experiments that revealed tyrosine hydroxylase and GluR1, GluR2/3, GluR4 or NMDAR1 immunoreactivity in the same sections.
Negative_regulation (revealed) of GluR1
8) Confidence 0.38 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840222 Disease Relevance 0.18 Pain Relevance 0.58
Sufficient amounts of glutamate can be released from axon terminals from all areas to cause cell hippocampal and cortical neurons, but also by neurons from any of the brain regions tested after chronic deprivation of glutamate receptor stimulation during development.
Negative_regulation (deprivation) of glutamate receptor in brain associated with glutamate and glutamate receptor
9) Confidence 0.38 Published 1996 Journal Neuroscience Section Abstract Doc Link 8884763 Disease Relevance 0.39 Pain Relevance 0.70
Conversely, the level of GluR1 was significantly decreased in the crude cytosolic fraction and increased in the crude membrane fraction from the ipsilateral L4–5 dorsal horn at 24 h (but not at 2 h) post-CFA injection.
Negative_regulation (decreased) of GluR1 in dorsal horn associated with dorsal horn
10) Confidence 0.37 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2628655 Disease Relevance 0.40 Pain Relevance 0.42
Because cerebral protection by hypothermia may involve a decrease in glutamate receptor activity, we also examined the interaction of temperature and isoflurane on glutamate receptor inhibition.
Spec (examined) Negative_regulation (inhibition) of glutamate receptor associated with hypothermia, glutamate receptor and isoflurane
11) Confidence 0.37 Published 1994 Journal Anesthesiology Section Abstract Doc Link 7992916 Disease Relevance 0.53 Pain Relevance 0.49
The effect of gamma-aminobutyric acid (GABA)A receptors and of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor blockade on clonidine hypotension was studied.
Negative_regulation (blockade) of glutamate receptor associated with gaba, glutamate receptor, hypotension and clonidine
12) Confidence 0.37 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7724054 Disease Relevance 0.50 Pain Relevance 0.59
It might also be that the absence of AMPAR GluA1 subunit resulted in a compensatory regulation mechanism for NMDARs because AMPARs and NMDARs are tightly coregulated by activity at the synapses.
Negative_regulation (absence) of AMPAR GluA1 in synapses
13) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.65 Pain Relevance 0.05
Thirty minutes after the end of stress, a significant decrease in the phosphorylation level of Ser831-GluA1 was found in mPFC and DH of stressed animals compared to controls (t (19)?
Negative_regulation (decrease) of GluA1 associated with stress and hippocampus
14) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.41 Pain Relevance 0.26
In synapses larger than 0.1 microm(2), GluR1 subunits were recovered in very low numbers.
Negative_regulation (recovered) of GluR1 in synapses
15) Confidence 0.30 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18815255 Disease Relevance 0 Pain Relevance 0.20
Glutamate receptor antagonists not only fully blocked EPSCs but IPSCs were also frequently reduced by the specific d,l,-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist (by 66.9%), indicative of glutamate-driven inhibitory projections.
Negative_regulation (reduced) of Glutamate receptor associated with glutamate, antagonist and glutamate receptor
16) Confidence 0.29 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12632235 Disease Relevance 0.09 Pain Relevance 0.36
Previously, in cultured retinal neural cells, we found that the protein levels of GluR1 and GluR6/7 subunits decrease and GluR2 and KA2 subunits increase [29].
Negative_regulation (decrease) of GluR1 in neural
17) Confidence 0.29 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.55 Pain Relevance 0.34
Finally, the increase in neuronal water content normally associated with oxygen-glucose deprivation/reperfusion was prevented by Na+ channel or glutamate receptor blockade.
Negative_regulation (blockade) of glutamate receptor in neuronal associated with glutamate receptor
18) Confidence 0.29 Published 2001 Journal Neuroscience Section Abstract Doc Link 11301205 Disease Relevance 0.08 Pain Relevance 0.38
Glutamate hyperexcitability and seizure-like activity throughout the brain and spinal cord upon relief from chronic glutamate receptor blockade in culture.
Negative_regulation (blockade) of glutamate receptor in spinal cord associated with glutamate, convulsion, glutamate receptor, hyperexcitability and spinal cord
19) Confidence 0.28 Published 1996 Journal Neuroscience Section Title Doc Link 8884763 Disease Relevance 0.28 Pain Relevance 0.70
Relief from chronic glutamate receptor block also increased inhibitory activity, as revealed by an increase in inhibitory postsynaptic currents while neurons were voltage-clamped at -25 mV.
Negative_regulation (block) of glutamate receptor in neurons associated with glutamate receptor
20) Confidence 0.28 Published 1996 Journal Neuroscience Section Abstract Doc Link 8884763 Disease Relevance 0.26 Pain Relevance 0.79

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