INT49624

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.80
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Sp5)
Anatomy Link Frequency
neurons 2
tail 1
nasal 1
motoneurons 1
Sp5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 4 100.00 Very High Very High Very High
central sensitization 1 100.00 Very High Very High Very High
Glutamate 6 99.98 Very High Very High Very High
Glutamate receptor 2 99.48 Very High Very High Very High
antagonist 1 98.72 Very High Very High Very High
local anesthetic 2 98.22 Very High Very High Very High
Inflammation 37 96.88 Very High Very High Very High
Inflammatory stimuli 1 96.14 Very High Very High Very High
Central nervous system 28 92.56 High High
Pain 41 89.64 High High
Disease Link Frequency Relevance Heat
Nociception 17 100.00 Very High Very High Very High
INFLAMMATION 41 96.88 Very High Very High Very High
Pain 32 89.64 High High
Nervous System Injury 27 89.52 High High
Infection 26 87.44 High High
Inflammatory Pain 3 83.40 Quite High
Sleep Disorders 2 82.72 Quite High
Heart Rate Under Development 1 77.32 Quite High
Paralysis 1 74.72 Quite High
Injury 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The evoked activity of Sp5O convergent neurons could be suppressed by noxious heat applied to the tail (52 degrees C) and long-lasting poststimulus effects followed this.
Negative_regulation (suppressed) of Sp5O in tail
1) Confidence 0.43 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 9987009 Disease Relevance 0 Pain Relevance 0.31
To investigate the origin of this response, four procedures were used to block the trigeminal pathway. 1) Trigeminal receptors within the nasal passages were anesthetized by infusing local anesthetic through the external nares. 2) Trigeminal nerves that innervate the nasal passages were sectioned bilaterally as they passed through the orbit. 3) The trigeminal neural pathway was blocked within the brain stem by either electrolytically lesioning or infusing local anesthetic into the spinal trigeminal nucleus interpolaris (Sp5I). 4) Synaptic transmission within Sp5I was prevented by infusing glutamate receptor antagonists D-2-amino-7-phosphonoheptanoic acid and 6,7-dinitroquinoxaline-2,3-dione.
Negative_regulation (prevented) of Sp5I in nasal associated with antagonist, glutamate receptor and local anesthetic
2) Confidence 0.38 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7573570 Disease Relevance 0.31 Pain Relevance 0.32
Microinjection of glutamate decreased the noxious-evoked response in Sp5c and Mo5 neurons in parallel with the JOR, without modifying spontaneous neuronal activity of trigeminal motoneurons (n = 8 pairs).
Negative_regulation (decreased) of Sp5c in motoneurons associated with glutamate
3) Confidence 0.24 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15738277 Disease Relevance 0.23 Pain Relevance 0.22
The microinjection of glutamate (80 etamol/0.5 microl) into striatal JOR inhibitory sites significantly decreased the A delta and C fiber-mediated-evoked response (53 +/- 4.2 and 43.6 +/- 6.4% of control value, P < 0.0001) in 92% (31/34) of nociceptive Sp5c neurons.
Negative_regulation (decreased) of Sp5c in neurons associated with nociception, c fibre and glutamate
4) Confidence 0.24 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15738277 Disease Relevance 0.26 Pain Relevance 0.23
However, some studies using other inflammatory stimuli, such as application of inflammatory irritant mustard oil in the tooth pulp, demonstrated that inhibition of P38 MAPK signaling and inhibition of astrocytes metabolic processes can completely abolish central sensitization in Sp5C nociceptive neurons [57,58].
Negative_regulation (abolish) of Sp5C in neurons associated with nociception, central sensitization, inflammation and inflammatory stimuli
5) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992508 Disease Relevance 1.00 Pain Relevance 0.81

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