INT49643

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 39
Total Number 66
Disease Relevance 46.49
Pain Relevance 40.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
spinal cord 8
brain 4
aorta 2
nervous system 2
liver 2
Bdkrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 3276 100.00 Very High Very High Very High
bradykinin 896 100.00 Very High Very High Very High
antagonist 548 100.00 Very High Very High Very High
Inflammation 428 100.00 Very High Very High Very High
Pain 356 100.00 Very High Very High Very High
b2 receptor 24 100.00 Very High Very High Very High
Analgesic 8 100.00 Very High Very High Very High
aspirin 3 100.00 Very High Very High Very High
Spinal cord 549 99.96 Very High Very High Very High
dorsal root ganglion 179 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 950 100.00 Very High Very High Very High
Brain Hemorrhage 4 99.92 Very High Very High Very High
Targeted Disruption 172 99.90 Very High Very High Very High
Pressure And Volume Under Development 549 99.82 Very High Very High Very High
Neuropathy 126 99.82 Very High Very High Very High
Congenital Anomalies 94 99.78 Very High Very High Very High
INFLAMMATION 441 99.72 Very High Very High Very High
Neuropathic Pain 1205 99.56 Very High Very High Very High
Pain 321 99.56 Very High Very High Very High
Ganglion Cysts 186 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pharmacological profile of the B1R expressed in the transgenic rat matches that expected of the human, but not the rat receptor.
Gene_expression (expressed) of B1R associated with targeted disruption
1) Confidence 0.78 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15051800 Disease Relevance 0.79 Pain Relevance 0.29
Membranes prepared from whole brain homogenates of heterozygous transgenic rats indicate a B1R expression level of 30 to 40 fmol/mg; there is no detectable B1R expression in control nontransgenic rats.
Neg (no) Gene_expression (expression) of B1R in brain associated with targeted disruption
2) Confidence 0.78 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15051800 Disease Relevance 0.77 Pain Relevance 0.30
Autoradiographic analyses of tissue sections from transgenic rats reveal that the B1R is broadly expressed in both the brain and spinal cord.
Gene_expression (expressed) of B1R in spinal cord associated with targeted disruption and spinal cord
3) Confidence 0.78 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15051800 Disease Relevance 0.88 Pain Relevance 0.29
The human B1R expressed in the transgenic rat functions in an in vitro contractile assay and thus has the potential to elicit a functional response in vivo.
Gene_expression (expressed) of B1R associated with targeted disruption
4) Confidence 0.78 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15051800 Disease Relevance 0.87 Pain Relevance 0.26
To circumvent these issues, we generated a transgenic rat expressing the human B1R under the control of the neuron-specific enolase promoter.
Gene_expression (expressing) of B1R in neuron associated with targeted disruption
5) Confidence 0.78 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15051800 Disease Relevance 0.63 Pain Relevance 0.30
However, the in vivo characterization of the pharmacodynamics of B1R antagonists is hindered by the low level of B1R expression in healthy tissue and the profound species selectivity exhibited by many compounds for the human B1R.
Gene_expression (expression) of B1R associated with antagonist
6) Confidence 0.78 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15051800 Disease Relevance 0.49 Pain Relevance 0.32
Membranes prepared from whole brain homogenates of heterozygous transgenic rats indicate a B1R expression level of 30 to 40 fmol/mg; there is no detectable B1R expression in control nontransgenic rats.
Gene_expression (expression) of B1R in brain associated with targeted disruption
7) Confidence 0.78 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15051800 Disease Relevance 0.71 Pain Relevance 0.30
Northern blot analysis confirmed the lack of B1 receptor expression in dorsal root ganglia, as B1 mRNA was neither detected under normal conditions nor after nerve injury.
Gene_expression (expression) of B1 receptor in nerve associated with nervous system injury and b1 receptor
8) Confidence 0.78 Published 2001 Journal Neuroreport Section Abstract Doc Link 11568657 Disease Relevance 0.44 Pain Relevance 0.67
In the present study, we have investigated whether there is a basal expression of B1 receptor in dorsal root ganglion (DRG) and trigeminal ganglion neurons in rats.
Gene_expression (expression) of B1 receptor in trigeminal ganglion associated with ganglion cysts, dorsal root ganglion, b1 receptor and trigeminal ganglion neurons
9) Confidence 0.78 Published 2000 Journal Neuroreport Section Abstract Doc Link 11192618 Disease Relevance 0.65 Pain Relevance 0.49
The kinin B1 receptor is generally expressed after inflammation or tissue injury.
Gene_expression (expressed) of kinin B1 receptor associated with inflammation, b1 receptor and injury
10) Confidence 0.77 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10203234 Disease Relevance 0.20 Pain Relevance 0.56
This is consistent with the increased B1R mRNA and protein expression following a 12 h exposure of mesenteric vascular endothelial cells with 25 mM glucose [39].
Gene_expression (expression) of B1R mRNA in endothelial cells associated with b1 receptor
11) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.24 Pain Relevance 0.42
The antagonist was without effect on the basal expression of B1R mRNA in control rats.


Gene_expression (expression) of B1R mRNA associated with b1 receptor and antagonist
12) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.10 Pain Relevance 0.68
Recent evidence suggests a link between insulin resistance, oxidative stress, pain polyneuropathy and the overexpression of kinin B1 receptor [1], [2], [3].
Gene_expression (overexpression) of kinin B1 receptor associated with neuropathy, stress, pain, b1 receptor and insulin resistance
13) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.83 Pain Relevance 0.70
Similarly to the spinal cord, levels of B1R mRNA were relatively low in aorta, liver and gastrocnemius muscle of control rats (Figure 5).
Gene_expression (levels) of B1R mRNA in spinal cord associated with b1 receptor and spinal cord
14) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.06 Pain Relevance 0.81
Recently, we reported that all these abnormalities including B1R overexpression were reduced with a diet containing alpha-lipoic acid or N-Acetyl-L-Cysteine, two potent antioxidants [2], [3], supporting a link between the upregulation of B1R, diabetic complications and the oxidative stress.
Gene_expression (overexpression) of B1R associated with stress, diabetes complications, congenital anomalies and b1 receptor
15) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.16 Pain Relevance 1.11
This overexpression of B1R binding sites in glucose-fed rats was significantly reduced in all laminae by the one-week treatment with 10 mg/kg SSR240612.
Gene_expression (overexpression) of B1R associated with b1 receptor
16) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.06 Pain Relevance 0.62
A selective B1R antagonist (SSR240612) was administered acutely (3–30 mg/kg) or daily for a period of 7 days (10 mg/kg) and the impact was measured on systolic blood pressure, allodynia, protein and/or mRNA B1R expression, aortic superoxide anion (O2•?)
Gene_expression (expression) of B1R in blood associated with allodynia, antagonist and b1 receptor
17) Confidence 0.76 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935380 Disease Relevance 1.11 Pain Relevance 0.57
The one-week treatment with 10 mg/kg SSR240612 reversed completely B1R mRNA overexpression in aorta and skeletal muscle and reduced significantly B1R mRNA level in the liver of glucose-fed rats.
Gene_expression (overexpression) of B1R mRNA in liver associated with b1 receptor
18) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.08 Pain Relevance 0.78
Also the experimental model of hypertension induced by chronic infusion of ANG II induced B1R expression in rat aorta [52] and spinal cord [53] as previously shown in cultured vascular smooth muscle [54] through a mechanism associated with the oxidative stress and NF-kB.
Gene_expression (expression) of B1R in aorta associated with stress, pressure and volume under development, b1 receptor and spinal cord
19) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.82 Pain Relevance 0.34
As shown in figure 4C, B1R mRNA was underexpressed in the spinal cord of control rats.
Gene_expression (underexpressed) of B1R mRNA in spinal cord associated with b1 receptor and spinal cord
20) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.06 Pain Relevance 0.71

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