INT49651

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 2
Speculated 7
Reported most in Body
Documents 276
Total Number 283
Disease Relevance 114.77
Pain Relevance 111.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
hippocampus 16
neurons 15
spinal cord 12
cerebellum 8
lateral 8
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 902 100.00 Very High Very High Very High
Hippocampus 462 100.00 Very High Very High Very High
depression 364 100.00 Very High Very High Very High
Kinase C 237 100.00 Very High Very High Very High
antagonist 182 100.00 Very High Very High Very High
addiction 154 100.00 Very High Very High Very High
Lasting pain 79 100.00 Very High Very High Very High
adenocard 37 100.00 Very High Very High Very High
Thermal hyperalgesia 27 100.00 Very High Very High Very High
Calcitonin gene-related peptide 12 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cold Sores 1680 100.00 Very High Very High Very High
Depression 392 100.00 Very High Very High Very High
Pain 314 100.00 Very High Very High Very High
Aids-related Complex 78 100.00 Very High Very High Very High
Hyperalgesia 74 100.00 Very High Very High Very High
Urological Neuroanatomy 7629 99.98 Very High Very High Very High
Stress 8392 99.92 Very High Very High Very High
Diabetes Mellitus 1262 99.84 Very High Very High Very High
Neuropathic Pain 138 99.76 Very High Very High Very High
INFLAMMATION 119 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracerebroventricular infusions of antisense CREB oligodeoxynucleotides significantly reduced the 24-hour carotid-artery ligation-induced neuroprotection effects by decreasing CREB expressions.
Gene_expression (expressions) of CREB in artery associated with intracerebroventricular
1) Confidence 0.78 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15470752 Disease Relevance 0.62 Pain Relevance 0.13
To determine the role of CREB in the BSTLD, adenovirus-mediated expression of a dominant-negative form of CREB (mCREB) was carried out.
Gene_expression (expression) of CREB
2) Confidence 0.78 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19968712 Disease Relevance 0.29 Pain Relevance 0.15
Because the tyrosine hydroxylase (TH), prodynorphin (PDYN), and proenkephalin (PENK) genes contain cAMP response elements that control their expression in their promoters, we used histochemical methods to determine whether ovarian steroids alter expression of the cAMP response element-binding protein (CREB) in the AVPV.
Gene_expression (expression) of CREB in AVPV
3) Confidence 0.78 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8622133 Disease Relevance 0 Pain Relevance 0.21
Because the tyrosine hydroxylase (TH), prodynorphin (PDYN), and proenkephalin (PENK) genes contain cAMP response elements that control their expression in their promoters, we used histochemical methods to determine whether ovarian steroids alter expression of the cAMP response element-binding protein (CREB) in the AVPV.
Gene_expression (expression) of cAMP response element-binding protein in AVPV
4) Confidence 0.78 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8622133 Disease Relevance 0 Pain Relevance 0.21
At the cellular level, CREBGFP expression in the LC in vivo and in vitro had no significant effect on neuronal firing at baseline but enhanced the excitatory effect of forskolin (an activator of adenylyl cyclase) on these neurons, which suggests that the cAMP signaling pathway in these neurons was sensitized after CREB expression.
Gene_expression (expression) of CREB in neurons associated with locus ceruleus
5) Confidence 0.78 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16641242 Disease Relevance 0 Pain Relevance 0.95
The CB-HRP/pCREB double labeling method was used to observe the expression of pCREB in the distal cerebrospinal fluid contacting neurons.
Gene_expression (expression) of pCREB in neurons
6) Confidence 0.77 Published 2009 Journal Neurol. Res. Section Body Doc Link 19108758 Disease Relevance 0.08 Pain Relevance 0
We evaluated morphine dependence by measuring the behavioral expression of morphine withdrawal and pCREB double labeled neuron recordings of dorsal raphe nucleus.
Gene_expression (expression) of pCREB in raphe nucleus
7) Confidence 0.77 Published 2009 Journal Neurol. Res. Section Body Doc Link 19108758 Disease Relevance 0.08 Pain Relevance 0
OBJECTIVE: To investigate the changes of pCREB protein expression in the distal cerebrospinal fluid contacting neurons induced by chronic morphine dependence and withdrawal.
Spec (investigate) Gene_expression (expression) of pCREB in cerebrospinal fluid associated with addiction, withdrawal and morphine
8) Confidence 0.77 Published 2009 Journal Neurol. Res. Section Abstract Doc Link 19108758 Disease Relevance 0.10 Pain Relevance 0.31
Changes in the expression and immunoreactivity of CREB and its phosphorylated proteins (CREB-IR and pCREB-IR) in the dorsal horn of the spinal cord were also measured.
Gene_expression (expression) of CREB in spinal cord
9) Confidence 0.77 Published 2007 Journal Anesth. Analg. Section Body Doc Link 18042889 Disease Relevance 0.25 Pain Relevance 0
RESULTS: The expression of CREB-IR and pCREB-IR proteins was shown to increase for 2 wk after PSNL.
Gene_expression (expression) of CREB
10) Confidence 0.77 Published 2007 Journal Anesth. Analg. Section Body Doc Link 18042889 Disease Relevance 0.23 Pain Relevance 0
Rats given moderate spinal cord injury (SCI) display increases in the expression of the activated form of the transcription factor cyclic AMP responsive element binding protein (CREB) in spinal segments of dermatomes corresponding to permanent mechanical allodynia, a model of chronic central neuropathic pain (CNP; (Crown, E.D., Ye, Z., Johnson, K.M., Xu, G.Y., McAdoo, D.J., Westlund, K.N., Hulsebosch, C.E., 2005.
Gene_expression (expression) of CREB in Crown associated with allodynia, frailty, neuropathic pain, dermatone and spinal cord
11) Confidence 0.77 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16478624 Disease Relevance 0.75 Pain Relevance 0.55
Rats given moderate spinal cord injury (SCI) display increases in the expression of the activated form of the transcription factor cyclic AMP responsive element binding protein (CREB) in spinal segments of dermatomes corresponding to permanent mechanical allodynia, a model of chronic central neuropathic pain (CNP; (Crown, E.D., Ye, Z., Johnson, K.M., Xu, G.Y., McAdoo, D.J., Westlund, K.N., Hulsebosch, C.E., 2005.
Gene_expression (expression) of cyclic AMP responsive element binding protein in Crown associated with allodynia, frailty, neuropathic pain, dermatone and spinal cord
12) Confidence 0.77 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16478624 Disease Relevance 0.75 Pain Relevance 0.55
that increasing CREB expression in
Gene_expression (expression) of CREB
13) Confidence 0.77 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.21 Pain Relevance 0.41
rats based on previous findings, and on the prediction that increased CREB expression in Handled CREB rats would increase pCREB-lir.
Gene_expression (expression) of CREB
14) Confidence 0.77 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.39 Pain Relevance 0.11
open arm avoidance in the EPM, and supports the notion that inducing CREB expression per se induces an anxious state
Gene_expression (expression) of CREB in arm
15) Confidence 0.77 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.66 Pain Relevance 0.18
expression of CREB in the right
Gene_expression (expression) of CREB
16) Confidence 0.77 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.16 Pain Relevance 0.32
injection is likely an underestimate of its value at peak expression of CREB, which occurs at three days after HSV
Gene_expression (expression) of CREB associated with cold sores
17) Confidence 0.77 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.41 Pain Relevance 0.06
robust effects of predator stress and virally induced CREB expression on brain and behavior.
Gene_expression (expression) of CREB in brain associated with stress
18) Confidence 0.77 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.44 Pain Relevance 0.11
Viral vectoring to induce CREB expression in the right lateral column of the PAG produced behavioral effects resembling those
Gene_expression (expression) of CREB in lateral column associated with central grey
19) Confidence 0.77 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.52 Pain Relevance 0.12
Further studies examining CREB and pCREB expression in lateral PAG at 1–3 days post HSV injection are required to
Gene_expression (expression) of CREB in lateral associated with cold sores and central grey
20) Confidence 0.77 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.06 Pain Relevance 0.30

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