INT49653

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 9.51
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB2) extracellular matrix organization (NFKB2) DNA binding (NFKB2)
cytoplasm (NFKB2) cytosol (NFKB2) signal transduction (NFKB2)
Anatomy Link Frequency
plaques 2
fat 1
NFKB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 295 99.64 Very High Very High Very High
tolerance 15 98.04 Very High Very High Very High
cytokine 105 97.44 Very High Very High Very High
Enkephalin 6 96.68 Very High Very High Very High
Inflammatory stimuli 36 93.92 High High
Inflammatory response 72 88.32 High High
Analgesic 2 86.00 High High
antagonist 4 84.24 Quite High
Spinal cord 1 82.40 Quite High
tetrodotoxin 1 79.76 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 5 100.00 Very High Very High Very High
INFLAMMATION 395 99.64 Very High Very High Very High
Hypoxia 35 99.58 Very High Very High Very High
Necrosis 16 98.92 Very High Very High Very High
Cancer 43 98.74 Very High Very High Very High
Atherosclerotic Plaque 7 97.96 Very High Very High Very High
Atherosclerosis 16 97.36 Very High Very High Very High
Infection 96 96.24 Very High Very High Very High
Apoptosis 432 95.40 Very High Very High Very High
Shigella Infection 9 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS AND RESULTS: We analyzed the expression of apoptotic genes such as BAX, CASP1, FAS, FAS L, FOS, MDM2, NFkB2, P53, PCNA, TERT, and XRCC1 in coronary plaques collected with directional coronary atherectomy from 15 patients with stable angina and 15 with acute coronary syndromes without ST elevation (ACS).
Spec (analyzed) Gene_expression (expression) of NFkB2 in plaques
1) Confidence 0.61 Published 2004 Journal Circulation Section Body Doc Link 15364800 Disease Relevance 0.19 Pain Relevance 0
Gene expression analysis showed that the proapoptotic genes (ie, BAX, CASP1, FAS, FAS L, FOS, NFkB2, P53, PCNA) were significantly more expressed (P<0.001) in ACS plaques, whereas the antiapoptotic genes (ie, MDM2, TERT, XRCC1) were more transcribed (P<0.001) in stable angina plaques.
Gene_expression (expressed) of NFkB2 in plaques
2) Confidence 0.61 Published 2004 Journal Circulation Section Body Doc Link 15364800 Disease Relevance 0.13 Pain Relevance 0
Developing an NFkB dependent indirect response model of inflammation
Gene_expression (dependent) of NFkB associated with inflammation
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.88 Pain Relevance 0.52
Also in support of this hypothesis, there was no change in expression of JUN, BIRC2/cIAP1, TRAF2, or NFKB2.
Gene_expression (expression) of NFKB2
4) Confidence 0.32 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.41 Pain Relevance 0
However, the induction of this gene does not affect the expression of NFKB2 in WTSTS cells since NFKB2 has about the same level of expression as WT cells in the U versus WT comparison.
Gene_expression (expression) of NFKB2
5) Confidence 0.28 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.46 Pain Relevance 0
However, the induction of this gene does not affect the expression of NFKB2 in WTSTS cells since NFKB2 has about the same level of expression as WT cells in the U versus WT comparison.
Gene_expression (expression) of NFKB2
6) Confidence 0.28 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.48 Pain Relevance 0
NFkB resides in the cytoplasm and is bound to its inhibitor.
Gene_expression (resides) of NFkB
7) Confidence 0.16 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.75 Pain Relevance 0.27
He also developed the collaboration with SP, and collectively they demonstrated the role of yucca phenolics as inhibitors of NFkB and iNOS production.



Gene_expression (production) of NFkB
8) Confidence 0.16 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1440857 Disease Relevance 0.45 Pain Relevance 0.10
RESULTS: Tumor necrosis factor alpha significantly induced messenger RNA (mRNA) and protein expression of cell adhesion molecules as well as transcriptional activity of nuclear factor kappaB.
Gene_expression (expression) of nuclear factor kappaB
9) Confidence 0.13 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.07 Pain Relevance 0
These include NFkB signalling, complement and coagulation cascades,
Gene_expression (include) of NFkB
10) Confidence 0.10 Published 2008 Journal Journal of Oncology Section Body Doc Link PMC2648637 Disease Relevance 0.96 Pain Relevance 0.44
These include NFkB signalling, complement and coagulation cascades,
Gene_expression (signalling) of NFkB
11) Confidence 0.10 Published 2008 Journal Journal of Oncology Section Body Doc Link PMC2648637 Disease Relevance 0.95 Pain Relevance 0.44
To isolate the nuclear protein fraction and to measure nuclear NFkB p65 levels, cells were processed after 2 hours of coculture using a commercial TransAM™ NF-kB family ELISA-based kit according to the manufacturer's instructions (Active Motif, Rixensart, Belgium).


Gene_expression (levels) of NFkB
12) Confidence 0.09 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.16 Pain Relevance 0.06
Several well characterized cis-elements, including AP2, CREB, NF1, and NFkB, reside on this region of the rENK gene.
Gene_expression (reside) of NFkB
13) Confidence 0.07 Published 1995 Journal Mol. Neurobiol. Section Abstract Doc Link 7576307 Disease Relevance 0 Pain Relevance 0.31
Specific keywords, terms, and their combinations including searches with MESH terminology (i.e., “obesity and COPD and review”) were used in three areas: (1) terms related to clinical manifestations of COPD: “chronic obstructive pulmonary disease”, “adipose tissue”, “morbidity”, “mortality”, “clinical outcomes”, “exacerbation”, “comorbidities”, “systemic manifestations”, “obesity”, “cachexia”, “weight loss”; (2) terms related to systemic inflammation: “systemic inflammation”, “hypoxia”, “inflammatory cytokines”, “adipokines”, “transcription factors”, “gene expression”, “tumor necrosis factor”, “interleukin”, “hypoxia-inducible factor”, “nuclear factor-kappa B”; (3) terms related to metabolic state: “insulin resistance”, “nutrition”, “body composition”, “fat mass”, “fat-free mass”, “resting energy expenditure”.
Gene_expression (resistance) of nuclear factor-kappa B in fat associated with pulmonary disease, hypoxia, insulin resistance, cytokine, appetite loss, necrosis, inflammation, weight loss, cancer and obesity
14) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 2.18 Pain Relevance 0.29
Nuclear factor kappa-B (NFkB) inhibitor (I-kB) is also expressed by NO.
Neg (NO) Gene_expression (expressed) of NFkB
15) Confidence 0.03 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 1.42 Pain Relevance 0.30

General Comments

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